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The abuse potential of lemborexant, a dual orexin receptor antagonist, according to the 8 factors of the Controlled Substances Act
RationaleLemborexant (LEM) is a dual orexin receptor antagonist (DORA) approved in multiple countries including the USA, Japan, Canada, Australia,...
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A consideration of CYP2D6 genetic variations in the Ghanaian population as a potential ‘culprit’ for the tramadol ‘abuse crisis’
BackgroundCytochrome P450 2D6 is involved in the metabolism of several important medicines including opioids. Variations in CYP2D6 have been...
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Opioid abuse and SIV infection in non-human primates
Human immunodeficiency virus (HIV) and drug abuse are intertwined epidemics, leading to compromised adherence to combined antiretroviral therapy...
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Substance abuse and neurodegenerative diseases: focus on ferroptosis
Psychostimulants and alcohol are widely abused substances with the adverse effects on global public health. Substance abuse seriously harms people's...
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Abuse and dependence potential of sphingosine-1-phosphate (S1P) receptor modulators used in the treatment of multiple sclerosis: a review of literature and public data
Abuse and misuse of prescription drugs remains an ongoing concern in the USA and worldwide; thus, all centrally active new drugs must be assessed for...
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Health effects associated with exposure to intimate partner violence against women and childhood sexual abuse: a Burden of Proof study
The health impacts of intimate partner violence against women and childhood sexual abuse are not fully understood. Here we conducted a systematic...
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Effect of Stanozolol and/or Cannabis Abuse on Hypertrophic Mechanism and Oxidative Stress of Male Albino Rat Cardiac Tissue in Relation to Exercise: A Sport Abuse Practice
Adolescents commonly co-abuse many drugs including anabolic androgenic steroids either they are athletes or non-athletes. Stanozolol is the major...
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The imidazoline I2 receptor agonist 2-BFI reduces abuse-related effects of morphine: self-administration and drug discrimination
RationaleIncreasing evidence shows that imidazoline I 2 receptor agonists enhance opioid-induced analgesia, suggesting that the combination of I 2 ...
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Design of Abuse-Deterrent Formulations Using Various Types of Thermal Deformed Starch (TDS)
PurposeIn recent years, the problem of drug abuse has emerged and is becoming more serious. Drug abuse can be secretly and illegally perpetuated by...
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Unique Pharmacology, Brain Dysfunction, and Therapeutic Advancements for Fentanyl Misuse and Abuse
Fentanyl is a fully synthetic opioid with analgesic and anesthetic properties. It has become a primary driver of the deadliest opioid crisis in the...
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A Chewing Study of Abuse-Deterrent Tablets Containing Polyethylene Oxide Using a Robotic Simulator
Abuse-deterrent formulations (ADFs) refer to formulation technologies aiming to deter the abuse of prescription drugs by making the dosage forms...
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Assessment of the abuse potential of methamnetamine in rodents: a behavioral pharmacology study
RationaleMethamnetamine (MNA; PAL-1046) is a new psychoactive substance that acts as a full biogenic amine transporter (BAT) substrate. BAT...
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Drugs of Abuse: Trends and Advanced Analytical Methods
Abuse of drugs is correlated with various medical, behavioral, psychological, spiritual, financial, social, family, and legal concerns and profoundly...
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New designer phenethylamines 2C-C and 2C-P have abuse potential and induce neurotoxicity in rodents
2C (2C-x) is the general name for the family of phenethylamines containing two methoxy groups at the 2 and 5 positions of the benzene ring. The abuse...
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Abuse, dependence and withdrawal associated with fentanyl and the role of its (designated) route of administration: an analysis of spontaneous reports from Europe
PurposeFentanyl, a highly potent synthetic opioid used in cancer and non-cancer pain, is approved for various routes of administration. In Europe,...
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Cannabinoids Pharmacology, Abuse, and Addiction
Cannabis has a long history of therapeutic use and misuse. Δ-9-tetrahydrocannabinol (THC) was identified as the principle psychoactive component of...
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Effect of Manufacturing Process on the Retention of Abuse-Deterrent Properties of PEO-Matrix Tablets
Polyethylene oxide (PEO) is a widely used polymer in the development of abuse-deterrent oral formulations. Different manufacturing processes...
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Nicotine Pharmacology, Abuse, and Addiction
Despite increased public awareness of the substantial health risks, tobacco use remains one of the greatest public health concerns around the world....
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Reinstatement of nicotine conditioned place preference in a transgenerational model of drug abuse vulnerability in psychosis: Impact of BDNF on the saliency of drug associations
RationalePsychotic disorders such as schizophrenia are often accompanied by high rates of cigarette smoking, reduced quit success, and high relapse...
