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A novel apoE-mimetic increases brain apoE levels, reduces Aβ pathology and improves memory when treated before onset of pathology in male mice that express APOE3
BackgroundAlzheimer’s disease (AD) is characterized by cognitive dysfunction and amyloid plaques composed of the amyloid-beta peptide (Aβ). APOE is...
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A polygenic risk score for Alzheimer’s disease constructed using APOE-region variants has stronger association than APOE alleles with mild cognitive impairment in Hispanic/Latino adults in the U.S.
IntroductionPolygenic Risk Scores (PRSs) are summaries of genetic risk alleles for an outcome.
MethodsWe used summary statistics from five...
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APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype in Alzheimer’s disease pathology and brain diseases
ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human polymorphisms, apoE2, apoE3, and apoE4, and the genetic...
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Apolipoprotein E (ApoE) orchestrates adipose tissue inflammation and metabolic disorders through NLRP3 inflammasome
Obesity is a metabolic disorder characterized by the hypertrophy expansion of adipose tissue, resulting in dysregulated energy metabolism, and...
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ApoE—functionalization of nanoparticles for targeted brain delivery—a feasible method for polyplexes?
The blood–brain barrier (BBB) poses a major obstacle in the treatment of all types of central nervous system (CNS) diseases. Small interfering RNA...
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ApoE Mimetic Peptides as Therapy for Traumatic Brain Injury
The lack of targeted therapies for traumatic brain injury (TBI) remains a compelling clinical unmet need. Although knowledge of the pathophysiologic...
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ApoE: A Risk Factor for Dementia
Dementia, a neurocognitive disorder, is associated with memory impairment and cognitive dysfunction. Recent estimates propose that around 36 million...
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ApoE in Alzheimer’s disease: pathophysiology and therapeutic strategies
Alzheimer’s disease (AD) is the most common cause of dementia worldwide, and its prevalence is rapidly increasing due to extended lifespans. Among...
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Linking Cerebral Malaria Pathogenesis to APOE-Mediated Amyloidosis: Observations and Hypothesis
Although most children with cerebral malaria fully recover, more than a fifth of the survivors develop post-discharge neurodevelopmental sequelae...
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APOE effects on regional tau in preclinical Alzheimer’s disease
BackgroundAPOE variants are strongly associated with abnormal amyloid aggregation and additional direct effects of APOE on tau aggregation are...
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The APOE-R136S mutation protects against APOE4-driven Tau pathology, neurodegeneration and neuroinflammation
Apolipoprotein E4 ( APOE4 ) is the strongest genetic risk factor for late-onset Alzheimer’s disease (LOAD), leading to earlier age of clinical onset...
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Low testosterone levels relate to poorer cognitive function in women in an APOE-ε4-dependant manner
BackgroundPast research suggests that low testosterone levels relate to poorer cognitive function and higher Alzheimer’s disease (AD) risk; however,...
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Diabetes mellitus and risk of incident dementia in APOE ɛ4 carriers: an updated meta-analysis
Background and aimDiabetes raises the risk of dementia, mortality, and cognitive decline in the elderly, potentially because of hereditary variables...
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Advertisement by medical facilities as an opportunity route of APOE genetic testing in Japan: a website analysis
The APOE -ε4 allele(s) is a strong risk factor for Alzheimer’s disease (AD). A significant point of access for this allele testing is through services...
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Impact of APOE on amyloid and tau accumulation in argyrophilic grain disease and Alzheimer’s disease
Alzheimer’s disease (AD), characterized by the deposition of amyloid-β (Aβ) in senile plaques and neurofibrillary tangles of phosphorylated tau...
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Subjective cognitive concerns, APOE ε4, PTSD symptoms, and risk for dementia among older veterans
BackgroundPosttraumatic stress disorder (PTSD) and traumatic brain injury (TBI) are associated with self-reported problems with cognition as well as...
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Effects of autologous serum on TREM2 and APOE in a personalized monocyte-derived macrophage assay of late-onset Alzheimer’s patients
BackgroundAge-associated deterioration of the immune system contributes to a chronic low-grade inflammatory state known as “inflammaging” and is...
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Association between APOE-ε4 allele and cognitive function is mediated by Alzheimer’s disease pathology: a population-based autopsy study in an admixed sample
BackgroundApolipoprotein E ε4 allele (APOE-ε4) is the main genetic risk factor for late-onset Alzheimer’s disease (AD) and may impact cognitive...
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Humanized APOE genotypes influence lifespan independently of tau aggregation in the P301S mouse model of tauopathy
Apolipoprotein (APOE) E4 isoform is a major risk factor of Alzheimer’s disease and contributes to metabolic and neuropathological abnormalities...
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Challenges at the APOE locus: a robust quality control approach for accurate APOE genotyping
BackgroundGenetic variants within the APOE locus may modulate Alzheimer’s disease (AD) risk independently or in conjunction with APOE *2/3/4...
