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Model of Osteomyelitis in Rats
We developed a rat model of chronic osteomyelitis of the femur caused by Staphylococcus aureus . The clinical, histomorphological, and laboratory...
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The ameliorative effect of midazolam on empathy-like behavior in old rats
Although studies suggest that cognitive functions in the elderly are impaired, elderly people tend to be more successful and wiser in solving...
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Hyperinsulinemic–Euglycemic Clamp in Conscious Rats Based on the Tail Artery and Vein Catheterization
Insulin sensitivity evaluation is very important in the management and investigation of type 1 diabetes. Hyperinsulinemic–euglycemic clamp (HEC) is...
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Investigating the Impact of Intracerebroventricular Streptozotocin on Female Rats with and without Ovaries: Implications for Alzheimer’s Disease
To contribute to research on female models of Alzheimer’s disease (AD), our aim was to study the effect of intracerebroventricular (ICV) injection of...
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Celastrol ameliorates energy metabolism dysfunction of hypertensive rats by dilating vessels to improve hemodynamics
AbstractThe impact of hypertension on tissue and organ damage is mediated through its influence on the structure and function of blood vessels. This...
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Glucocorticoids modify intracranial pressure in freely moving rats
BackgroundGlucocorticoids (GCs) are widely prescribed for a variety of inflammatory diseases, but they are also used to treat raised intracranial...
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Role of curcumin on beta-amyloid protein, tau protein, and biochemical and oxidative changes in streptozotocin-induced diabetic rats
Diabetes is one of the most common endocrine metabolic diseases and is associated with the accumulation of beta-amyloid plaques in the brain. Amyloid...
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CSF hyperdynamics in rats mimicking the obesity and androgen excess characteristic of patients with idiopathic intracranial hypertension
BackgroundIdiopathic intracranial hypertension (IIH) is a syndrome exhibiting elevated intracranial pressure (ICP), visual disturbances, and severe...
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Influence of a Decrease in Blood Viscosity on Arterial Pressure in Normotensive and Spontaneously Hypertensive Rats
We investigated the effect of a decrease in blood viscosity on the mean BP during isovolumic hemodilution and vasodilating activity of the...
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Ectonucleotidase Activity in Smooth Muscle Tissues of Rats with a Valproate Model of Autism
Ectonucleotidases play an important role in regulating the level of extracellular nucleotides and nucleosides and are an important part of the...
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Impact of Liver Sympathetic Nervous System on Liver Fibrosis and Regeneration After Bile Duct Ligation in Rats
The sympathetic nervous system (SNS) affects many functions of the body. SNS fibers regulate many aspects of liver function, repair, and...
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Involvement of prelimbic cortex neurons and related circuits in the acquisition of a cooperative learning by pairs of rats
Social behaviors such as cooperation are crucial for mammals. A deeper knowledge of the neuronal mechanisms underlying cooperation can be beneficial...
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Assessment of melatonin’s therapeutic effectiveness against hepatic steatosis induced by a high-carbohydrate high-fat diet in rats
Several studies have demonstrated the protective effects of melatonin against metabolic diseases, such as liver steatosis. However, its therapeutic...
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SGLT2 inhibitor as a potential therapeutic approach in hyperthyroidism-induced cardiopulmonary injury in rats
Hyperthyroidism-induced cardiac disease is an evolving health, economic, and social problem affecting well-being. Sodium-glucose cotransporter...
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Adolescent alcohol binge drinking and withdrawal: behavioural, brain GFAP-positive astrocytes and acute methamphetamine effects in adult female rats
RationaleAlcopop beverages are generally the first alcoholic beverage that young females drink which contain high levels of sugar and alcohol. The...
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Effect of Noopept on the Content of Neurotransmitter Amino Acids in the Hippocampus in Alcoholized Rats Using In Vivo Microdialysis
Abstract — The aim of the present work was to study the dynamics of neurotransmitter amino acids after acute Noopept (a dipeptide analogue of piracetam...
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Distribution, Metabolism, and Excretion of Cenobamate in Adult, Fetal, Neonatal, and Lactating Rats
Background and ObjectiveCenobamate is an antiseizure medication (ASM) approved for treatment of focal epilepsy in adults. The objective of this...
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Effects of lipopolysaccharide administration at different postnatal periods on behavioral and biochemical assessments in Wistar rats
Rodent model systems using lipopolysaccharide (LPS) administration have been developed to examine the effect of postnatal inflammation on...
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Effect of Adrenoreceptor Stimulation on Peptidergic Regulation of Cardiac Activity in Newborn Rats
We studied the effect of adrenoreceptor stimulation on the frequency of spontaneous activity and amplitude-time parameters of isometric contraction...
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Combined in vivo metabolic effects of quetiapine and methadone in brain and blood of rats
Changes in pharmacokinetics and endogenous metabolites may underlie additive biological effects of concomitant use of antipsychotics and opioids. In...
