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The Role of Surgery in Management of Gastric Cancer
Gastric adenocarcinoma is an aggressive tumor with significant global burden. Incidence is decreasing in Western countries but gastric cancer remains...
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The Combinatorial Effect of Acetate and Propionate on High-Fat Diet Induced Diabetic Inflammation or Metaflammation and T Cell Polarization
High-fat diet (HFD) alters the gut microbiota and its fermentation products mainly acetate, propionate, and butyrate. Butyrate is well studied as a...
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The role of β2 integrin in dendritic cell migration during infection
BackgroundDendritic cells (DCs) play a key role in shaping T cell responses. To do this, DCs must be able to migrate to the site of the infection and...
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The function of Wtap in N6-adenosine methylation of mRNAs controls T cell receptor signaling and survival of T cells
T cell antigen-receptor (TCR) signaling controls the development, activation and survival of T cells by involving several layers and numerous...
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Puerarin reduces impairment of intestinal and adipose immune responses to influenza virus infection in mice
Influenza is an acute viral respiratory disease that can also cause gastroenteritis-like symptoms, such as abdominal pain, nausea, vomiting, and...
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Identification of Murine Innate Lymphoid Cell Subsets in Barrier Tissues and Their Draining Lymph Nodes Using Flow Cytometry
Innate lymphoid cells (ILCs) are present in most tissues within the body but have been most extensively studied within mucosal barriers such as the...
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Identification of Non-classical Follicular T Cells
Nonclassical T cells are a heterogeneous group of T lymphocytes that are activated during the early stages of infection and act as a bridge between...
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m6A RNA modification regulates innate lymphoid cell responses in a lineage-specific manner
Innate lymphoid cells (ILCs) can quickly switch from a quiescent state to an active state and rapidly produce effector molecules that provide...
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Fibroblastic reticular cell lineage convergence in Peyer’s patches governs intestinal immunity
Fibroblastic reticular cells (FRCs) determine the organization of lymphoid organs and control immune cell interactions. While the cellular and...
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Mining the microbiota to identify gut commensals modulating neuroinflammation in a mouse model of multiple sclerosis
BackgroundThe gut microbiome plays an important role in autoimmunity including multiple sclerosis and its mouse model called experimental autoimmune...
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Animal Tuberculosis: Gross Lesions and Anatomopathological Diagnosis
Animal tuberculosisTuberculosisanimal (TB) is a zoonotic diseaseDiseaseZoonotic with worldwide distributionDistribution that can cause serious...
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A neoadjuvant therapy compatible prognostic staging for resected pancreatic ductal adenocarcinoma
ObjectiveTo improve prediction, the AJCC staging system was revised to be consistent with upfront surgery (UFS) and neoadjuvant therapy (NAT) for...
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Age-Related Changes in Primary and Secondary Lymphoid Organs
Bone marrow is a primary lymphoid organ which gives rise to leukocytes and provides maturation of B cells whereas thymus is also a primary lymphoid...
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Inhibiting the redox function of APE1 suppresses cervical cancer metastasis via disengagement of ZEB1 from E-cadherin in EMT
BackgroundMetastasis is a major challenge in cervical cancer treatment. Previous studies have shown that the dual functional protein...
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Multicenter Experience of Hematopoietic Stem Cell Transplantation in WHIM Syndrome
PurposeWHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome is a rare disease, caused by CXCR4 gene mutations, which...
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Adrenergic Innervation of the thyroid Gland, Blood and Lymph Vessels, and Lymph Nodes in Hypothyroidism
Adrenergic innervation in the tissue of the thyroid gland, blood vessels of the thyroid gland, cervical lymphatic vessel, and lymph nodes in rats...
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Increased regulatory activity of intestinal innate lymphoid cells type 3 (ILC3) prevents experimental autoimmune encephalomyelitis severity
Experimental autoimmune encephalomyelitis (EAE) induced in inbred rodents, i.e., genetically identical animals kept under identical environmental...
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TCF-1 controls Treg cell functions that regulate inflammation, CD8+ T cell cytotoxicity and severity of colon cancer
The transcription factor TCF-1 is essential for the development and function of regulatory T (T reg ) cells; however, its function is poorly...
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Effect of Neoadjuvant and Adjuvant Therapy of Experimental Breast Cancer on the Structure of Mesenteric Lymph Nodes
The morphometric analysis of mesenteric lymph nodes was carried out in female Wistar rats with chemically induced breast cancer. In control rats with...
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T helper cell trafficking in autoimmune kidney diseases
CD4 + T cells are key drivers of autoimmune diseases, including crescentic GN. Many effector mechanisms employed by T cells to mediate renal damage...
