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Multilocus sequence typing (MLST), porA and flaA typing of Campylobacter jejuni isolated from cats attending a veterinary clinic
ObjectiveCampylobacter is a major cause of gastroenteritis in humans and pet ownership is a risk factor for infection. To study the occurrence,...
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A chemogenomic approach to identify personalized therapy for patients with relapse or refractory acute myeloid leukemia: results of a prospective feasibility study
Targeted next-generation sequencing (tNGS) and ex vivo drug sensitivity/resistance profiling (DSRP) have laid foundations defining the functional...
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Role of T-Type Ca2+ Channels in Painful Diabetic Neuropathy
Numerous investigations implicate pronounced changes in the functioning of T-type Ca 2+ channels localized on the somata of primary nociceptor units...
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Clostridium perfringens epsilon toxin vaccine candidate lacking toxicity to cells expressing myelin and lymphocyte protein
A variant form of Clostridium perfringens epsilon toxin (Y30A-Y196A) with mutations, which shows reduced binding to Madin–Darby canine kidney (MDCK)...
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Ligand-based virtual screening, consensus molecular docking, multi-target analysis and comprehensive ADMET profiling and MD stimulation to find out noteworthy tyrosine kinase inhibitor with better efficacy and accuracy
Inhibition of BCR–ABL tyrosine kinase plays a crucial role in the management of chronic myelogenous leukemia (CML). The suppression of CML is getting...
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Pcdh18a regulates endocytosis of E-cadherin during axial mesoderm development in zebrafish
The notochord defines the axial structure of all vertebrates during development. Notogenesis is a result of major cell reorganization in the...
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T cell epigenetic remodeling and accelerated epigenetic aging are linked to long-term immune alterations in childhood cancer survivors
BackgroundCancer treatments have substantially improved childhood cancer survival but are accompanied by long-term complications, notably chronic...
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Down Syndrome, Ageing and Epigenetics
During the past decades, life expectancy of subjects with Down syndrome (DS) has greatly improved, but age-specific mortality rates are still...
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Clinical approach to neurodegenerative disorders in childhood: an updated overview
Neurodegenerative disorders include a group of severe diseases that share a core including a gradual loss of previously acquired motor, sensory and...
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Viral Vector Gene Delivery to the Brain for Treating Neurogenetic Diseases
Treatment of neurogenetic diseases is often difficult, as potential treatment must correct pathology that is globally present. A promising approach...
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Progression Rate Associated Peripheral Blood Biomarkers of Parkinson’s Disease
Parkinson disease (PD) is one of the most frequent neurodegenerative disorders. The aim of this study was to identify blood biomarkers capable to...
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Enhanced CAR T cell expansion and prolonged persistence in pediatric patients with ALL treated with a low-affinity CD19 CAR
Chimeric antigen receptor (CAR)-modified T cells targeting CD19 demonstrate unparalleled responses in relapsed/refractory acute lymphoblastic...
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Microbial Production of Functional Organic Acids
As the low-molecular-weight organic compounds, organic acids, such as malate, alpha-ketoglutaric acid, citrate, and so on, have been applied in a...
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AAV Vector-Based Gene Therapy, Progress and Current Challenges
Therapeutic efficacy of the adeno-associated virus (AAV) vector gene transfer has been shown by the large number of proof-of-concept studies in...
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Investigation of the motor system in two siblings with Canavan’s disease: a combined transcranial magnetic stimulation (TMS) – diffusion tensor imaging (DTI) study
Canavan’s disease (CD) is a hereditary leukodystrophy caused by mutations in the aspartoacylase gene ( ASPA ), leading to spongiform degeneration of...
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Metabolic adaptations of tissue-resident immune cells
Unlike other cells in the body, immune cells have to be able to enter and adapt to life within diverse tissues. Immune cells develop within dedicated...
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Alzheimer’s disease phospholipase C-gamma-2 (PLCG2) protective variant is a functional hypermorph
BackgroundRecent Genome Wide Association Studies (GWAS) have identified novel rare coding variants in immune genes associated with late onset...
