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Bovine Leukemia Virus
In bovine pathology, research performed between 1871 and 1877 by Siedam-grotzky was apparently the first attempt to study bovine leukosis (BL) and...
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Protected endogenous retroviral sequences copurify with infectivity in experimental Creutzfeldt-Jakob disease
Scrapie and Creutzfeldt-Jakob disease (CJD) are caused by infectious agents that are defined phenomenologically. No agent-specific molecules or...
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Is ammonia a pathogenetic factor in Alzheimer's disease?
An attempt was made to review experimental evidence in favor of the idea that ammonia plays a role in dementia of the Alzheimer type (DAT)....
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Potential role of viruses in neurodegeneration
Viruses have the capacity to induce alterations and degenerations of neurons by different direct and indirect mechanisms. In the review, we have...
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Immunohistochemical demonstration of a new thiamine diphosphate-binding protein in the rat digestive tract
We purified a new thiamine diphosphate-binding protein (ThDP-BP), produced an antiserum against it, and examined its immunohistochemical distribution...
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Ultrastructural Studies of Prions
The scrapie prion protein denoted PrP 27–30 was discovered by enriching fractions for scrapie infectivity (Prusiner et al. 1982, 1983). This protein...
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Prion Protein Genes: Evolutionary and Functional Aspects
Over the past decade, a wealth of new information about the biological and physical properties as well as genetics of the particle causing scrapie...
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Genetics of Prion Diversity and Host Susceptibility
Although all priori diseases, including familial Creutzfeldt-Jakob disease (CJD) and Gerstmann—Sträussler syndrome (GSS), are transmissible by...
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The Scrapie Agent: “A Virus by Any Other Name”
Scrapie is a fatal, central nervous system disease of sheep and goats caused by a serially transmissible agent (Cuille and Chelle 1936) that passes...
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Purification of Scrapie Agents: How Far Have We Come?
It might seem, after a careful reading of the literature on the etiologic agents of scrapie and Creutzfeldt-Jakob disease (CJD), that at least three...
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Human Hepatitis Delta Virus
In the past few years significant progress has been made in understanding the structure and replication of hepatitis delta (HDV). Some of this work...
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Self, Nonself and the Paradoxes of Autoimmunity
It is difficult to know where to begin an essay on the problem of immunological discrimination between “self” and “nonself” and the paradoxes created...
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In Vitro Expression and Biosynthesis of Prion Protein
Prion protein (PrP) is an endogenous protein of central nervous system and a variety of other mammalian tissues (Chesebro et al. 1985; Oesch et al....
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The Period of Biochemistry and Molecular Genetics
The spectacular molecular genetic and molecular biological results of Delbrück and Luria in phage research after WorldWar II kindled the interest of...
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Amyloidosis
Amyloidosis was probably first described by Nicolaus Fontanus, however, he certainly did not use this term. In his book edited in 1639 and entitled...
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Possible Implications of the Cellular Component of the Immune System in the Pathogenesis of Unconventional Slow Virus Infections
A group of infectious degenerative disorders of the CNS naturally occurring in animals and man is referred as unconventional slow virus diseases...
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Moloney Murine Leukemia Virus Temperature-Sensitive Mutants: A Model for Retrovirus-Induced Neurologic Disorders
In the early 1960s Stansly observed in BALB/c mice a neurogenic paralysis of the hind limb associated with the cell-free transmission of a reticulum...
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Rubella Virus and Central Nervous System Disease
Rubella was first recognized as a distinct disease entity in the early 1800’s (68). For the next 125 years, rubella virus was considered to cause...
