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Abnormalities in Stress Proteins in Prion Diseases
1. Prion diseases include kuru, Creutzfeldt–Jakob disease (CJD), Gerstmann–Sträussler–Scheinker disease (GSS), and fatal familia insomnia (FFI) of...
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Immunity Against Microorganisms
Entry of a pathogenic organism into a susceptible host is followed by invasion and colonization of tissues, circumvention of the host immune response...
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Impaired Motor Coordination in Mice Lacking Prion Protein
1. Prion protein (PrP C ) is a host-encoded glycoprotein constitutively expressed on the neuronal cell surface. Accumulation of its protease-resistant...
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Immunology of Infection
Vaccinology can be viewed as an application of immunology. The two disciplines arose from a common root in the late nineteenth century, namely...
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Human Hepatitis Delta Virus: an Agent with Similarities to Certain Satellite RNAs of Plants
One of the most intriguing aspects of hepatitis delta virus (HDV) is that, even though it is a naturally occurring infectious agent of human beings,...
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An Overview of Mouse Models in Neuroscience Research
In 1965, Sidman et al. published the Catalog of the Neurological Mutants of the Mouse. This now classic treatise cataloged and described the...
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Protein Drug Manufacturing
Recombinant DNA technology has opened new avenues for producing many useful therapeutic proteins, such as hormones, growth factors, and interferons,...
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Transgene und Knockout-Mäuse für das Studium von neurodegenerativen Erkrankungen
Um detaillierte Analysen der Mechanismen, die den menschlichen, neurodegenerativen Erkrankungen zugrundeliegen, durchführen zu können, sind geeignete...
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A minimal glycine-alanine repeat prevents the interaction of ubiquitinated IκBα with the proteasome: a new mechanism for selective inhibition of proteolysis
The Epstein-Barr virus nuclear antigen 1 contains a glycine-alanine repeat that inhibits in cis MHC class l-restricted presentation. We report here...
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Polymerization of human prion peptide HuPrP 106–126 to amyloid in nucleic acid solution
The human prion peptide PrP106–126 polymerizes in the presence of DNA both in its circular and linearized forms under solution conditions where the...
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Complementary hydropathy identifies a cellular prion protein receptor
Prions, the etiological agents for infectious degenerative encephalopathies, act by entering the cell and inducing conformational changes in PrP c (a...
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Identification and localization of Chlamydia pneumoniae in the Alzheimer's brain
We assessed whether the intracellular bacterium Chlamydia pneumoniae was present in post-mortem brain samples from patients with and without...
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The human 37-kDa laminin receptor precursor interacts with the prion protein in eukaryotic cells
Prions are thought to consist of infectious proteins that cause transmissible spongiform encephalopathies 1 . According to overwhelming evidence, the...
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Increases in Fragmented Glial Fibrillary Acidic Protein Levels in the Spinal Cords of Patients with Amyotrophic Lateral Sclerosis
Using one-dimensional polyacrylamide gel electrophoresis, we analyzed protein fractions extracted from the spinal cords of patients with amyotrophic...
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Disruption of the LIF Receptor
The interleukin-6 (IL-6) family of cytokines and their receptors all require dimerization of one receptor subunit with gp130 to trans-duce an...
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Neuroimmunodegeneration Syndromes: Definition and Models
The two major biological systems that must monitor and respond appropriately to environmental changes are the nervous and immune (central and...
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Lexikon der Syndrome und Fehlbildungen
Genetisch bedingter Fehlbildungskomplex auf der Grundlage einer Genmutation.
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Comparative research on leukemia and related diseases: An introduction to a scientific approach
Publication in this journal of the abstracts of the Nineteenth Symposium of the International Association for Comparative Research on Leukemia and...
