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Inhibition of COX-2 ameliorates murine liver schistosomiasis japonica through splenic cellular immunoregulation
BackgroundWe have reported the positive association of the cyclooxygenase 2 (COX-2)/prostaglandin E2 (PGE2) axis with liver fibrosis induced by Schist...
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CD4+ T cell immunity is dependent on an intrinsic stem-like program
CD4 + T cells are central to various immune responses, but the molecular programs that drive and maintain CD4 + T cell immunity are not entirely clear....
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Upregulation of proBDNF in the Mesenteric Lymph Nodes in Septic Mice
The immune status in the lymphatic system, especially mesenteric lymph nodes (MLNs), is critical to regulate the septic shock. Brain-derived...
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The Interaction of Gut Microbiota with Immune System and Their Effects on Immune Cell Development and Function
The quest of revealing colonization of unicellular organisms in a multicellular organism, creating complex networks and regulating the host immunity...
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Tolerogenic Functions of Plasmacytoid Dendritic Cells
Dendritic cells in the steady state circulate throughout the body, home to tissues, sample antigens, migrate to draining lymph nodes through high...
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Extrathymic AIRE-Expressing Cells: A Historical Perspective
Since its discovery, Aire has been the topic of numerous studies in its role as a transcriptional regulator in the thymus where it promotes the...
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Primary Culture of Immunological Cells
This chapter begins with a brief description of the mechanisms associated with maintaining immunity (protection against disease-causing pathogens) in...
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From digestion and absorption to innate immunity and health care: water and food intake may contribute to IL-22 in ILC3-dependent mucosal immunity in the jejunum
In this review, with our current studies we demonstrated medical evidence that water and food intake are useful for IL-22-related mucosal...
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CT radiomics features of meso-esophageal fat in predicting overall survival of patients with locally advanced esophageal squamous cell carcinoma treated by definitive chemoradiotherapy
ObjectiveTo investigate the value of CT radiomics features of meso-esophageal fat in the overall survival (OS) prediction of patients with locally...
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Genomic and evolutionary characteristics of metastatic gastric cancer by routes
BackgroundIn gastric cancer (GC) patients, metastatic progression through the lymphatic, hematogenous, peritoneal, and ovarian routes, is the...
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Periplaneta americana extract ameliorates dextran sulfate sodium-induced ulcerative colitis via immunoregulatory and PI3K/AKT/NF-κB signaling pathways
Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) with a low cure rate. Periplaneta americana is a traditional American Cockroach...
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The phosphatidylinositol-transfer protein Nir3 promotes PI(4,5)P2 replenishment in response to TCR signaling during T cell development and survival
Hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP 2 ) by phospholipase C-γ (PLCγ1) represents a critical step in T cell antigen receptor (TCR)...
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Outcomes of surgical resection and intraoperative electron radiotherapy for patients with para-aortic recurrences of gastrointestinal and gynecologic malignancies
BackgroundPara-aortic lymph node (PALN) metastases from primary pelvic malignancies are often treated with resection, but recurrence is common. We...
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TNFR2 antagonistic antibody induces the death of tumor infiltrating CD4+Foxp3+ regulatory T cells
BackgroundTNFR2 expression is a characteristic of highly potent immunosuppressive tumor infiltrating CD4 + Foxp3 + regulatory T cells (Tregs). There is...
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Aging induces severe SIV infection accompanied by an increase in follicular CD8+ T cells with overactive STAT3 signaling
The number of elderly people living with HIV is increasing globally, and the condition of this population is relatively complicated due to the dual...
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A T follicular helper cell origin for T regulatory type 1 cells
Chronic antigenic stimulation can trigger the differentiation of antigen-experienced CD4 + T cells into T regulatory type 1 (TR1) cells, a subset of...
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ADP-ribosylating adjuvant reveals plasticity in cDC1 cells that drive mucosal Th17 cell development and protection against influenza virus infection
Migratory dendritic cells expressing CD103 are the targets for mucosal vaccines. These belong to either of two lineage-restricted subsets, cDC1 or...
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The IL-25-dependent tuft cell circuit driven by intestinal helminths requires macrophage migration inhibitory factor (MIF)
Macrophage migration inhibitory factor (MIF) is a key innate immune mediator with chemokine- and cytokine-like properties in the inflammatory...
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Pathological changes in various organs in HLA-B*57:01 transgenic mice with abacavir-induced skin eruption
Several patients with cutaneous adverse drug reactions exhibit extracutaneous organ damages, and it becomes severe in a few patients resulting in...
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The Role of Surgery in Management of Gastric Cancer
Gastric adenocarcinoma is an aggressive tumor with significant global burden. Incidence is decreasing in Western countries but gastric cancer remains...
