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The ethanolic extract of Aframomum angustifolium seeds protects against tamoxifen-induced side effects in rats with breast cancer
Long-term use of tamoxifen (TAM) is associated with severe side effects. The present study aimed at evaluating the protective effect of the ethanolic...
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Cell-autonomous effect of cardiomyocyte branched-chain amino acid catabolism in heart failure in mice
Parallel to major changes in fatty acid and glucose metabolism, defect in branched-chain amino acid (BCAA) catabolism has also been recognized as a...
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Effect of erythrophagocytosis-induced ferroptosis during angiogenesis in atherosclerotic plaques
Intraplaque (IP) angiogenesis is a key feature of advanced atherosclerotic plaques. Because IP vessels are fragile and leaky, erythrocytes are...
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The Effect of Cognitive-Behavioral Therapy and Coping Strategies on Sleep Disturbances During the COVID-19 Pandemic
The COVID-19 pandemic brought about several health problems, due to the disease itself, but also due to the indirect effects of the health measures...
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Effect of Caffeine Consumption on Cardiovascular Disease: An Updated Review
The incidence of cardiovascular diseases has significantly increased with the expansion of the industrialization of societies, which is notably...
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Sex-dimorphic neuroprotective effect of CD163 in an α-synuclein mouse model of Parkinson’s disease
Alpha-synuclein (α-syn) aggregation and immune activation represent hallmark pathological events in Parkinson’s disease (PD). The PD-associated...
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Subunit nanovaccine elicited T cell functional activation controls Trypanosoma cruzi mediated maternal and placental tissue damage and improves pregnancy outcomes in mice
This study investigated a candidate vaccine effect against maternal Trypanosoma cruzi (Tc) infection and improved pregnancy outcomes. For this, TcG2 ...
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Lentinan has a beneficial effect on cognitive deficits induced by chronic Toxoplasma gondii infection in mice
BackgroundToxoplasma gondii ( T. gondii ) is increasingly considered a risk factor for neurodegenerative diseases. However, there is only limited...
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Effect of Pre/Probiotic Supplementation on Metabolic Endotoxemia
Metabolic endotoxemia (ME) refers to a condition in which endotoxin levels (lipopolysaccharide) are significantly elevated in the blood, without the...
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Losartan treatment attenuates hindlimb unloading-induced atrophy in the soleus muscle of female rats via canonical TGF-β signaling
We investigated the protective effect of losartan, an angiotensin II type 1 receptor blocker, on soleus muscle atrophy. Age-matched male and female...
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The effect of ellagic acid on sex hormones and miRNA-21 expression in rats with polycystic ovary syndrome
PurposePolycystic ovary syndrome (PCOS) is a common endocrine disorder that affects women of reproductive age. It is characterized by irregular...
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Beneficial effects of curcumin in the diabetic rat ovary: a stereological and biochemical study
This study aimed to investigate the effects of curcumin treatment on ovaries at different periods of the diabetes disease. Fifty-six female Wistar...
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Protective effect of zerumbone on sepsis-induced acute lung injury through anti-inflammatory and antioxidative activity via NF-κB pathway inhibition and HO-1 activation
Sepsis is a systemic illness for which there are no effective preventive or therapeutic therapies. Zerumbone, a natural molecule, has anti-oxidative...
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Ameliorative and Neuroprotective Effect of Core-Shell Type Se@Au Conjugated Hesperidin Nanoparticles in Diabetes-Induced Cognitive Impairment
Diabetes mellitus is the most chronic metabolic ailment characterized by insulin deficiency leading to aberrant cognitive dysfunction in later...
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A non-randomized controlled trial to assess the protective effect of SMC in the context of high parasite resistance in Uganda
BackgroundUntil recently, due to widespread prevalence of molecular markers associated with sulfadoxine-pyrimethamine (SP) and amodiaquine (AQ)...
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Effect of treatment regimen of the rheumatoid arthritis patients on the risk of coronavirus disease 2019 by modulating the inflammatory mediators
BackgroundThe therapeutic profile of the patients with rheumatoid arthritis (RA) commonly consists of immunosuppressive and anti-inflammatory...
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Neuroprotective effect of piracetam-loaded magnetic chitosan nanoparticles against thiacloprid-induced neurotoxicity in albino rats
Thiacloprid (TH) is a neurotoxic agricultural insecticide and potential food contaminant. The purpose of this study was to investigate the...
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Intersectionality in Alzheimer’s Disease: The Role of Female Sex and Black American Race in the Development and Prevalence of Alzheimer’s Disease
It is well known that vascular factors and specific social determinants of health contribute to dementia risk and that the prevalence of these risk...
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Loss of microRNA-30a and sex-specific effects on the neonatal hyperoxic lung injury
BackgroundBronchopulmonary dysplasia (BPD) is characterized by an arrest in lung development and is a leading cause of morbidity in premature...
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Sex-based differences in natural killer T cell-mediated protection against diet-induced steatohepatitis in Balb/c mice
BackgroundMetabolic dysfunction-associated steatotic liver disease (MASLD) is prevalent in Western countries, evolving into metabolic...
