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Identification of a Novel Gene Encoding a PrP-Like Protein Expressed as Chimeric Transcripts Fused to PrP Exon 1/2 in Ataxic Mouse Line with a Disrupted PrP Gene
1. Mouse lines lacking prion protein (PrP C ) have a puzzling phenotypic discrepancy. Some, but not all, developed late-onset ataxia due to Purkinje...
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Alzheimer’s Disease: Physiological and Pathogenetic Role of the Amyloid Precursor Protein (APP), its Aβ-Amyloid Domain and Free Aβ-Amyloid Peptide
To understand synaptic loss and neurodegeneration in Alzheimer’s disease, we have tried to consider the physiological functions of the amyloid...
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Aß Toxicity in Alzheimer’s Disease
The first diagnosed Alzheimer’s disease patient was Auguste D (Fig. 1), a middle-aged woman cared for by Alsatian clinician-pathologist Alois...
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Prions: from neurografts to neuroinvasion
Spongiform encephalopathies are infectious neurodegenerative diseases caused by pathogens that seem to be devoid of any informational nucleic acids....
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Glial Fibrillary Acidic Protein: GFAP-Thirty-One Years (1969–2000)
It is now well established that the glial fibrillary acidic protein (GFAP) is the principal 8–9 nm intermediate filament in mature astrocytes of the...
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Antibodies in human infectious disease
Investigation of human antibody responses to viral pathogens at the molecular level is revealing novel aspects of the interplay of viruses with the...
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Therapeutic control of cytokines: lessons from microorganisms
The systems of innate and acquired immunity that protect us from the vast numbers of potential parasites that live in our environment (prions,...
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Pharmacological manipulation of early PrPres accumulation in the spleen of scrapie-infected mice
In most experimental models of scrapie and in some naturally infected species, the lymphoreticular system and the spleen in particular play a major...
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Follicular dendritic cells in scrapie pathogenesis
Scrapie pathogenesis was studied in chimaeric mice that carried the prion protein (PrP) gene only in particular cells of the immune system. These...
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Cellular and sub-cellular localisation of PrP in the lymphoreticular system of mice and sheep
Using immunocytochemistry or immunogold electron microscopy, abnormal PrP accumulation was found in lymphoreticular tissues of Suffolk sheep...
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Mutational Analysis of Tau in Chromosome 17-Linked Dementia
A series of families with mixed neurodegenerative disorders has been linked to chromosome 17q21–22 by chromosome segregation analysis. Collectively,...
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The prion protein globular domain and disease-related mutants studied by molecular dynamics simulations
In humans, familial forms of transmissible spongiform enceph-alopathies (TSE; “prion diseases”) have been shown to segregate with the exchange of...
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Polymerization of murine recombinant prion protein in nucleic acid solution
Recombinant prion protein has been used earlier to understand the structural properties of cellular prion protein PrP C and to understand...
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The Impact of Genetic Removal of GFAP and/or Vimentin on Glutamine Levels and Transport of Glucose and Ascorbate in Astrocytes
The importance of the intermediate filament (IF) proteins glial fibrillary acidic protein (GFAP) and vimentin for astrocyte function was studied by...
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Advanced Transgenic and Gene-Targeting Approaches
Over the past two decades the techniques associated with the manipulation of the mouse genome have provided a powerful approach toward the better...
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B lymphocytes in prion neuroinvasion: Central or peripheral players?
New findings suggest that B cells are not as important for prion replication in peripheral tissues and for prion transport to the central nervous...
