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1. SEL1L preserves CD8⁺ T-cell survival and homeostasis by fine-tuning PERK signaling and the IL-15 receptor-mediated mTORC1 axis

   SEL1L-mediated endoplasmic reticulum-associated degradation (ERAD) plays critical roles in controlling protein homeostasis by degrading misfolded or...

   Yafeng Gao, Wenhui Li, ... Lianjun Zhang in Cellular & Molecular Immunology

   Article 30 August 2023
   

2. Receptor-interacting protein kinase 1 (RIPK1) as a therapeutic target

   Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) is a key mediator of cell death and inflammation. The unique hydrophobic pocket in the...

   Lauren Mifflin, Dimitry Ofengeim, Junying Yuan in Nature Reviews Drug Discovery

   Article 15 July 2020
   

3. Role of apoptosis repressor with caspase recruitment domain (ARC) in cell death and cardiovascular disease

   Apoptosis repressor with caspase recruitment domain (ARC) is a highly effective and multifunctional inhibitor of apoptosis that is mainly expressed...

   Jing Zhang, Xianxin Zheng, ... Wei Ding in Apoptosis

   Article 19 February 2021
   

4. Dark-Side of Exosomes

   Exosomes are nanoscale extracellular vesicles that can transport cargos of proteins, lipids, DNA, various RNA species and microRNAs (miRNAs)....

   Atilla Engin in Protein Kinase-mediated Decisions Between Life and Death

   Chapter 2021
   

5. Necrostatin-1S mitigates type-2 diabetes-associated cognitive decrement and lipotoxicity-induced neuro-microglia changes through p-RIPK-RIPK3-p-MLKL axis

   Type-2 diabetes mellitus (T2DM) is associated with neuroinflammation and cognitive decrement. Necroptosis programmed necrosis is emerging as the...

   Kumari Preeti, Valencia Fernandes, ... Shashi Bala Singh in Metabolic Brain Disease

   Article 10 March 2023
   

6. Ptpn6 inhibits caspase-8- and Ripk3/Mlkl-dependent inflammation

   Ptpn6 is a cytoplasmic phosphatase that functions to prevent autoimmune and interleukin-1 (IL-1) receptor-dependent, caspase-1-independent...

   Mary Speir, Cameron J. Nowell, ... Ben A. Croker in Nature Immunology

   Article 09 December 2019
   

7. Necroptosis activation in Alzheimer's disease

   Alzheimer's disease (AD) is characterized by severe neuronal loss; however, the mechanisms by which neurons die remain elusive. Necroptosis, a...

   Antonella Caccamo, Caterina Branca, ... Salvatore Oddo in Nature Neuroscience

   Article 24 July 2017
   

8. Upregulation of PSMB4 is Associated with the Necroptosis after Spinal Cord Injury

   Spinal cord injury (SCI) is one of the most common and severe complications in spine injury. It is difficult to prevent cell necroptosis and promote...

   Chunshuai Wu, Jiajia Chen, ... Zhiming Cui in Neurochemical Research

   Article 11 August 2016
   

9. Reactive astrocytes undergo M1 microglia/macrohpages-induced necroptosis in spinal cord injury

   Background

   A unique feature of the pathological change after spinal cord injury (SCI) is the progressive enlargement of lesion area, which usually...

   Hong Fan, Kun Zhang, ... Ya-Zhou Wang in Molecular Neurodegeneration

   Article Open access 03 February 2016
   

10. The diverse role of RIP kinases in necroptosis and inflammation

    Inflammation is a healthy response to infection or danger and should be rapid, specific and terminated once the threat has passed. Inflammatory...

    John Silke, James A Rickard, Motti Gerlic in Nature Immunology

    Article 18 June 2015
    

11. Regulated cell death and inflammation: an auto-amplification loop causes organ failure

    Regulated cell death (RCD) is either immunologically silent or immunogenic. RCD in parenchymal cells may lead to the release of damage- associated...

    Andreas Linkermann, Brent R. Stockwell, ... Hans-Joachim Anders in Nature Reviews Immunology

    Article 17 October 2014