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Potential role of inducible nitric oxide synthase (iNOS) activity in testicular dysfunction following co-administration of alcohol and combination antiretroviral therapy (cART) in diabetic rats: an immunohistochemistry study
Diabetes, alcohol abuse, and combination antiretroviral therapy (cART) use have been reported to cause multi-organ complications via induction of...
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Prognostic significance of natural killer cell-associated markers in gastric cancer: quantitative analysis using multiplex immunohistochemistry
BackgroundNatural killer (NK) cells mediate the anti-tumoral immune response as an important component of innate immunity. The aim of this study was...
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HER2 amplification by next-generation sequencing to identify HER2-positive invasive breast cancer with negative HER2 immunohistochemistry
BackgroundHuman epidermal growth factor receptor 2 (HER2 ) positive breast carcinomas due to HER2 amplification are associated with aggressive...
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Utility of a new notation to visualize flow cytometry analysis results: first preliminary comparison with immunohistochemistry to detect CD30 expression on T-cell lymphoma cells
BackgroundIt is important to confirm CD30 expression in T-cell lymphoma cases, but immunohistochemical staining for CD30 is not commonly performed...
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Utility of Immunohistochemistry and Immunofluorescence in Determining the Pathogenic Variants of Chronic Granulomatous Disease
BackgroundChronic granulomatous disease (CGD) is a primary immunodeficiency disorder of phagocytes due to defects in any of the five subunits of...
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Utility of CD138/syndecan-1 immunohistochemistry for localization of plasmacytes is tissue-dependent in B6 mice
ObjectiveInflammation is present in many diseases and identification of immune cell infiltration is a common assessment. CD138 (syndecan-1) is a...
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Fetal growth at term and placental oxidative stress in a tissue micro-array model: a histological and immunohistochemistry study
This study examines 8-hydroxyguanine (8-oxo-Gua) staining in placental tissue samples based on fetal size at birth as well as its relationships with...
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Fluorescence Immunohistochemistry Techniques for Labeling Metabotropic Glutamate Receptors in the Central Nervous System
Immunohistochemistry (IHC) is a common and highly effective method for staining histological samples for specific molecular targets. The large number...
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Immunohistochemistry for Ion Channels and Their Interacting Molecules: Tips for Improving Antibody Accessibility
Elucidating the molecular organization at synapses is essential for understanding brain function and plasticity. Immunohistochemistry is widely used...
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Automated Immunohistochemistry Assay for the Detection of Napsin-A in Formalin-Fixed Paraffin-Embedded Tissues from Lung Tumors
Immunohistochemistry (IHC) enables the selective detection of proteins in cells of formalin-fixed-paraffin-embedded (FFPE) tissue sections. This...
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Automated TTF-1 Immunohistochemistry Assay for the Differentiation of Lung Adenocarcinoma Versus Lung Squamous Cell Carcinoma
Due to therapeutic advances, the subclassification of non-small cell lung carcinomas (NSCLC) between the adenocarcinomas and squamous cell carcinomas...
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Proficiency testing of diagnosis in histopathology and immunohistochemistry of breast pathology in China: results from a pilot work of National Single Disease Quality Control Program for breast cancer
AimPathologists are currently supposed to be aware of both domestic and international guidelines for breast cancer diagnosis, but it is unclear how...
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Multiplex Immunohistochemistry Analysis of Melanoma Tumor-Infiltrating Lymphocytes
Tumor-infiltrating lymphocytes (TILs) are an important prognostic indicator in melanoma and play a key role in the patient’s response to immune...
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An exploration of immunohistochemistry-based prognostic markers in patients undergoing curative resections for colon cancer
BackgroundThe immune system recognizes and destroys cancer cells. However, cancer cells develop mechanisms to avoid detection by expressing cell...
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Co-labeling of Neuronal Cells Using DiI Neuronal Filling and Immunohistochemistry to Explore Metabotropic Glutamate Receptor Expression
Neuronal morphology, including microarchitecture, can provide insightful information regarding neuronal physiology. Dendritic spines are highly...
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Functional estrogen receptor signaling pathway activity in high-grade serous ovarian carcinoma as compared to estrogen receptor protein expression by immunohistochemistry
PurposeAnti-estrogen therapy may be used as a palliative treatment option in high-grade serous ovarian carcinomas (HGSC). However, clinical...
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Application of Immunohistochemistry in Basic and Clinical Studies
Immunohistochemistry (IHC), also known as immunohistochemical staining, is an immune morphological analysis. It is a process of selectively...
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Detection of Programmed Cell Death Ligand 1 Expression in Lung Cancer Clinical Samples by an Automated Immunohistochemistry System
Programmed cell death 1 (PD-1) plays an important role in subsiding immune responses, in promoting self-tolerance through suppressing the activity of...
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Discrepancy of p16 immunohistochemical expression and HPV RNA in penile cancer. A multiplex in situ hybridization/immunohistochemistry approach study
BackgroundThe high-risk human papillomavirus (HPV) infection represents one of the main etiologic pathways of penile carcinogenesis in approximately...
