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Introduction to “The Mesentery in Inflammation”
All abdominal digestive organs are directly connected to the mesentery. A significant proportion of the immune system is located in the mesentery and...
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Momordica charantia phytoconstituents can inhibit human T-lymphotropic virus type-1 (HTLV-1) infectivity in vitro and in vivo
There is an urgent need to find an effective therapy for life-threatening HTLV-1-associated diseases. Bitter melon ( Momordica charantia ) is...
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Evidence of Long-range nerve pathways connecting and coordinating activity in secondary lymph organs
BackgroundPeripheral nerve reflexes enable organ systems to maintain long-term physiological homeostasis while responding to rapidly changing...
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rVSV-ΔG-SARS-CoV-2-S vaccine: repeated intramuscular (IM) toxicity, local tolerance, immunogenicity and biodistribution study in NZW rabbits
BriLife ® , a vector-based vaccine that utilizes the recombinant vesicular stomatitis virus (VSV) platform to express and present the spike antigen of...
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TH17 cell heterogeneity and its role in tissue inflammation
Since their discovery almost two decades ago, interleukin-17-producing CD4 + T cells (T H 17 cells) have been implicated in the pathogenesis of multiple...
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Single-cell atlases: shared and tissue-specific cell types across human organs
The development of single-cell and spatial transcriptomics methods was instrumental in the conception of the Human Cell Atlas initiative, which aims...
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Skin and gut imprinted helper T cell subsets exhibit distinct functional phenotypes in central nervous system autoimmunity
Multidimensional single-cell analyses of T cells have fueled the debate about whether there is extensive plasticity or ‘mixed’ priming of helper T...
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The role of DGAT1 and DGAT2 in regulating tumor cell growth and their potential clinical implications
Lipid metabolism is widely reprogrammed in tumor cells. Lipid droplet is a common organelle existing in most mammal cells, and its complex and...
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Tissue-based IL-10 signalling in helminth infection limits IFNγ expression and promotes the intestinal Th2 response
Type 2 immunity is activated in response to both allergens and helminth infection. It can be detrimental or beneficial, and there is a pressing need...
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Targeting the Mesentery with Surgery
Traditionally, other than its role in lymphadenectomy for neoplastic disease, the mesentery has not been the target of surgery in gastrointestinal...
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Tissue adaptation and clonal segregation of human memory T cells in barrier sites
T lymphocytes migrate to barrier sites after exposure to pathogens, providing localized immunity and long-term protection. Here, we obtained blood...
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Bergapten enhances mitophagy to regulate intestinal barrier and Th17/Treg balance in mice with Crohn’s disease-like colitis via PPARγ/NF-κB signaling pathway
This study aimed to investigate whether bergapten (BG), a furanocoumarin phytohormone, holds promise for Crohn’s disease (CD)-like colitis treatment...
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Structural Parameters of Mesenteric Lymph Nodes in Mice Exposed to Factors of Modeled Aerial Environment of Space Vehicles
The effects of inhalation exposure to a mixture containing acetone, acetaldehyde, and ethanol in concentrations typical of closed environment in...
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A virtual memory CD8+ T cell-originated subset causes alopecia areata through innate-like cytotoxicity
Virtual memory T (T VM ) cells are a T cell subtype with a memory phenotype but no prior exposure to foreign antigen. Although T VM cells have antiviral...
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Water intake releases serotonin from enterochromaffin cells in rat jejunal villi
The present study aims to investigate the roles of water intake in serotonin production and release in rat jejunum. We evaluated the changes in...
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Expression characteristics of immune factors in secondary lymphoid organs of newborn, juvenile and adult yaks (Bos grunniens)
Little is known about lymphoid organ development in yaks. In this study, we characterize and evaluate the main markers of T cell, B cell, plasma cell...
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tRNA-m1A modification promotes T cell expansion via efficient MYC protein synthesis
Naive T cells undergo radical changes during the transition from dormant to hyperactive states upon activation, which necessitates de novo protein...
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Systematic post-mortem analysis of brain tissue from an HIV-1 subtype C viremic decedent revealed a paucity of infection and pathology
Whether the human brain is a robust reservoir for HIV-1 subtype C has yet to be established. We aimed to determine whether HIV-1 subtype C infection...
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CD4+ T cell immunity is dependent on an intrinsic stem-like program
CD4 + T cells are central to various immune responses, but the molecular programs that drive and maintain CD4 + T cell immunity are not entirely clear....
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piRNA-18 Inhibition Cell Proliferation, Migration and Invasion in Colorectal Cancer
Colorectal cancer is one of the most prevalent malignancies worldwide. Evidences indicate that piRNA-18 are closely involved and contributed to...
