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Genetics and Epigenetics of Nonsuicidal Self-Injury: A Narrative Review
AbstractNonsuicidal self-injury (NSSI), or self-harm, is widespread, especially among young people. However, despite the problem’s relevance, NSSI...
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Genetics of circadian rhythms and sleep in human health and disease
Circadian rhythms and sleep are fundamental biological processes integral to human health. Their disruption is associated with detrimental...
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Genetics and Epigenetics of Manganese Toxicity
Purpose of ReviewAt elevated levels, the essential element manganese (Mn) is neurotoxic and increasing evidence indicates that environmental Mn...
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Generation of Defective Interfering Particles of Morbilliviruses Using Reverse Genetics
RNA viruses generate defective genomes naturally during virus replication. Defective genomes that interfere with the infection dynamics either...
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Combined effect of microbially derived cecal SCFA and host genetics on feed efficiency in broiler chickens
BackgroundImproving feed efficiency is the most important goal for modern animal production. The regulatory mechanisms of controlling feed efficiency...
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Latina immigrants’ breast and colon cancer causal attributions: genetics is key
Latinos in the US suffer health disparities including stage of disease at time of breast or colon cancer diagnosis. Understanding Latinas’ causal...
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Genetics and Differential Diagnosis of Cerebellar Ataxias
Ataxias are a complex and heterogeneous group of disorders characterized by the absence of order and coordination of voluntary movements and loss of...
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Use of Reverse Genetics for the Generation of Recombinant Influenza Viruses Carrying Nanoluciferase
Influenza A (FLUAV) and influenza B (FLUBV) viruses are human and/or animal pathogens widely studied due to their importance to public health and...
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Elucidating causative gene variants in hereditary Parkinson’s disease in the Global Parkinson’s Genetics Program (GP2)
The Monogenic Network of the Global Parkinson’s Genetics Program (GP2) aims to create an efficient infrastructure to accelerate the identification of...
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The genetics of non-monogenic IBD
Inflammatory bowel disease (IBD), with Crohn’s disease and ulcerative colitis as main subtypes, is a prototypical multifactorial disease with both...
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Genetics in ophthalmology: molecular blueprints of retinoblastoma
This review presents current knowledge on the molecular biology of retinoblastoma (RB). Retinoblastoma is an intraocular tumor with hereditary and...
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Reverse Genetics Systems for Filoviruses
Filoviruses are causative agents of severe hemorrhagic fevers with high case fatality rates in humans. For studies of virus biology and the...
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Approaching discussions about genetics with palliative patients and their families: a qualitative exploration with genetic health professionals
Genetic information can provide clinical benefits to families of palliative patients. However, integration of genetics into mainstream medicine has...
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Human genetics education as part of the Japanese Cancer Education Comprehensive Support Project
In Japan, cancer education has been initiated with children as a measure against cancer. Cancer genome medicine, which is a social implementation,...
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Recombinant Cedar Virus: A Henipavirus Reverse Genetics Platform
The isolation of Cedar virus, a nonpathogenic henipavirus that is closely related to the highly pathogenic Nipah virus and Hendra virus, provides a...
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From Mendel to quantitative genetics in the genome era: the scientific legacy of W. G. Hill
The quantitative geneticist W. G. (‘Bill’) Hill, awardee of the 2018 Darwin Medal of the Royal Society and the 2019 Mendel Medal of the Genetics...
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Defining the causes of sporadic Parkinson’s disease in the global Parkinson’s genetics program (GP2)
The Global Parkinson’s Genetics Program (GP2) will genotype over 150,000 participants from around the world, and integrate genetic and clinical data...
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Ten challenges for clinical translation in psychiatric genetics
Genome-wide association studies have identified hundreds of robust genetic associations underlying psychiatric disorders and provided important...
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Reanalysis of genomic data in rare disease: current practice and attitudes among Australian clinical and laboratory genetics services
Reanalyzing stored genomic data over time is highly effective in increasing diagnostic yield in rare disease. Automation holds the promise of...
