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Brain magnetic resonance imaging in the DE50-MD dog model of Duchenne muscular dystrophy reveals regional reductions in cerebral gray matter
BackgroundDuchenne muscular dystrophy is a X-linked disease characterized by severe and progressive muscle weakness, alongside cognitive impairment...
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Correlates of Protection from Tuberculosis
Multiple immunological mechanisms interact to protect against Mycobacterium tuberculosis (M.tb) infection and/or tuberculosis (TB) disease. However,...
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Data-driven identification and classification of nonlinear aging patterns reveals the landscape of associations between DNA methylation and aging
BackgroundAging affects the incidence of diseases such as cancer and dementia, so the development of biomarkers for aging is an important research...
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Exome sequencing reveals genetic heterogeneity and clinically actionable findings in children with cerebral palsy
Cerebral palsy (CP) is the most common motor disability in children. To ascertain the role of major genetic variants in the etiology of CP, we...
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Mir-139-5p inhibits glioma cell proliferation and progression by targeting GABRA1
Glioma is an extremely aggressive malignant neoplasm of the central nervous system. MicroRNA (miRNA) are known to bind to specific target mRNA to...
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NGS-based expanded carrier screening for genetic disorders in North Indian population reveals unexpected results – a pilot study
BackgroundTo determine the carrier frequency and pathogenic variants of common genetic disorders in the north Indian population by using next...
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Amino Acids in Microbial Metabolism and Function
Amino acidsAmino acids (AAs) not only serve as building blocks for protein synthesis in microorganisms but also play important roles in their...
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Microorganisms in the Pathogenesis and Management of Spondyloarthritis
Spondyloarthritis is an umbrella term for a group of inflammatory diseases of the joints and spine. The group includes ankylosing spondylitis,...
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Rat models of human diseases and related phenotypes: a systematic inventory of the causative genes
The laboratory rat has been used for a long time as the model of choice in several biomedical disciplines. Numerous inbred strains have been...
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Long-term trial of protection provided by adenovirus-vectored vaccine expressing the PPRV H protein
A recombinant, replication-defective, adenovirus-vectored vaccine expressing the H surface glycoprotein of peste des petits ruminants virus (PPRV)...
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A novel risk score model based on eight genes and a nomogram for predicting overall survival of patients with osteosarcoma
BackgroundThis study aims to identify a predictive model to predict survival outcomes of osteosarcoma (OS) patients.
MethodsA RNA sequencing dataset...
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Mitochondrial Dysfunction as a Signaling Target for Therapeutic Intervention in Major Neurodegenerative Disease
Neurodegenerative diseases (NDD) are incurable and the most prevalent cognitive and motor disorders of elderly. Mitochondria are essential for a wide...
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Cytotoxicity and growth-inhibiting activity of Astragalus polysaccharides against breast cancer via the regulation of EGFR and ANXA1
Astragalus polysaccharide (APS) has been frequently used as an adjuvant agent responsible for its immunoregulatory activity to enhance efficacy and...
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A screen for Plasmodium falciparum sporozoite surface protein binding to human hepatocyte surface receptors identifies novel host–pathogen interactions
BackgroundSporozoite invasion of hepatocytes is an essential step in the Plasmodium life-cycle and has similarities, at the cellular level, to...
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Species Selection for Pharmaceutical Toxicity Studies
Selecting the most appropriate animal species for toxicity testing increases the likelihood of detecting potential effects in humans. Regulatory...
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Identification of hub genes associated with prognosis, diagnosis, immune infiltration and therapeutic drug in liver cancer by integrated analysis
BackgroundLiver cancer is one of the most common cancers and causes of cancer death worldwide . The objective was to elucidate novel hub genes which...
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Preservation of a remote fear memory requires new myelin formation
Experience-dependent myelination is hypothesized to shape neural circuit function and subsequent behavioral output. Using a contextual fear memory...
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Modern Molecular Genetic Methods for Age Estimation in Forensics
This article presents a review of modern molecular genetic methods for estimating the age of an individual based on the analysis of various tissue...
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An in vivo accelerated developmental myelination model for testing promyelinating therapeutics
BackgroundTherapeutic agents stimulating the process of myelination could be beneficial for the treatment of demyelinating diseases, such as multiple...
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Residual risk for additional recessive diseases in consanguineous couples
PurposeConsanguineous couples are typically counseled based on familial pathogenic variants identified in affected children. The residual risk for...
