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Sex differences in resting-state functional networks in awake rats
Sex-related differences can be found in many brain disorders and psychophysiological traits, highlighting the importance to systematically understand...
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Endothelin mediates sex-differences in acclimation to high salt diet in rats
IntroductionCurrent understanding of sodium (Na + ) handling is based on studies done primarily in males. Contrary to the gradual increase in high...
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Pharmacokinetic Interaction Between Imatinib and Metformin in Rats
Background and ObjectiveImatinib is primarily transported into the liver by organic cation transporter 1 (OCT1), organic anion transporting...
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Aromatase inhibition and ketamine in rats: sex-differences in antidepressant-like efficacy
BackgroundKetamine has been recently approved to treat resistant depression; however preclinical studies showed sex differences in its efficacy. Sex...
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Neurexin1α knockout in rats causes aberrant social behaviour: relevance for autism and schizophrenia
RationaleGenetic and environmental factors cause neuropsychiatric disorders through complex interactions that are far from understood....
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Thiacloprid impairs reproductive functions of male Wistar rats
Global male infertility correlated to the rise of endocrine-disrupting chemicals, including insecticides, has grown into a pressing problem....
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Aucubin promotes activation of AMPK and alleviates cerebral ischemia/reperfusion injury in rats
In the current investigation, we explored the benefits of aucubin against rodent ischemia/reperfusion (I/R) damages in brains and elucidated the role...
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Age-Related Features of the Early Period of Liver Regeneration after Partial Hepatectomy in Rats
Regenerative processes in the liver were studied in 3-month-old (young) and 9-month-old (aged) male Wistar rats on day 1 after 30 and 70%...
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Sex Influences Genetic Susceptibility to Depression-Like Behaviors in Chronic Unpredictable Mild Stress-Exposed Wistar Rats
Depression is one of the most common mood disorders among psychiatric diseases. It affects about 10% of the adult population. However, its...
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Divergent Pattern of Development in Rats and Humans
Rattus norvegicus is the second most used laboratory species and the most widely used model in neuroscience. Nonetheless, there is still no agreement...
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Transcutaneous vagus nerve stimulation ameliorates cardiac abnormalities in chronically stressed rats
Chronically stressed patients often have low vagal tone and increased levels of proinflammatory cytokines, which increase their risk for developing...
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Estimation of Renal Clearance in Hypertensive Rats According to fMRI Data
Renal clearance in Wistar rats with multifactorial cardiovasorenal model of arterial hypertension was assessed by fMRI using (EPI_Diffusion_map)...
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Modafinil Improves Autism-like Behavior in Rats by Reducing Neuroinflammation
To evaluate the ameliorating effect of Modafinil on neuroinflammation, behavioral, and histopathological alterations in rats induced by propionic...
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Hemodynamic Parameters in Spontaneously Hypertensive Rats with Obesity and Chemically Induced Colitis during Probiotic Therapy
We studied the dynamics of the main hemodynamic parameters in spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats with visceral obesity...
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Noradrenergic modulation of play in Sprague-Dawley and F344 rats
RationaleFor many mammals, engaging in social play behavior as a juvenile is important for cognitive, social, and emotional health as an adult. A...
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The anti-COVID-19 drug Paxlovid crosses biological barriers of the placenta and brain in rats
Paxlovid (nirmatrelvir plus ritonavir) is an orally available drug for the treatment of COVID-19 disease. However, limited information remains on the...
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The role of beta-adrenoreceptors in postoperative ileus in rats
The aim of the research was to evaluate the influence of antagonists of specific beta-adrenergic receptor subtypes on bowel motility following...
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Effects of fentanyl self-administration on risk-taking behavior in male rats
RationaleIndividuals with opioid use disorder (OUD) exhibit impaired decision making and elevated risk-taking behavior. In contrast to the effects of...
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Human omentin-1 reduces vascular insulin resistance and hypertension in Otsuka Long-Evans Tokushima Fatty rats
PurposeHypertension is one of the major risk factors for renal failure and cardiovascular diseases, and is caused by various abnormalities including...
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Exercise-induced cardiac mitochondrial reorganization and enhancement in spontaneously hypertensive rats
The myocardium is a highly oxidative tissue in which mitochondria are essential to supply the energy required to maintain pump function. When...
