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Lentiviral gene therapy rescues p47phox chronic granulomatous disease and the ability to fight Salmonella infection in mice
Chronic granulomatous disease (CGD) is an inherited primary immunodeficiency disorder characterised by recurrent and often life-threatening...
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Developmental delay and late onset HBSL pathology in hypomorphic Dars1M256L mice
The leukodystrophy Hypomyelination with Brainstem and Spinal cord involvement and Leg spasticity (HBSL) is caused by recessive mutations of the DARS1 ...
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Discovery of a novel integron-borne aminoglycoside resistance gene present in clinical pathogens by screening environmental bacterial communities
BackgroundNew antibiotic resistance determinants are generally discovered too late, long after they have irreversibly emerged in pathogens and spread...
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Why we thrive beneath a northern sky – genomic signals of selection in apple for adaptation to northern Sweden
Good understanding of the genomic regions underlying adaptation of apple to boreal climates is needed to facilitate efficient breeding of locally...
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Objective hearing threshold identification from auditory brainstem response measurements using supervised and self-supervised approaches
Hearing loss is a major health problem and psychological burden in humans. Mouse models offer a possibility to elucidate genes involved in the...
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Uptake of prenatal genetic diagnosis and termination of pregnancy by Omani Muslim families at risk of genetic disorders: experience over a 9-year period
Studies on the acceptance of prenatal diagnosis and termination of pregnancy for single gene disorders within Islamic societies in the Middle East...
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Connections between cross-tissue and intra-tissue biomarkers of aging biology in older adults
BackgroundSaliva measures are generally more accessible than blood, especially in vulnerable populations. However, connections between aging biology...
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Mechanisms of axonal support by oligodendrocyte-derived extracellular vesicles
Extracellular vesicles (EVs) have recently emerged as versatile elements of cell communication in the nervous system, mediating tissue homeostasis....
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Classification of NF1 microdeletions and its importance for establishing genotype/phenotype correlations in patients with NF1 microdeletions
An estimated 5–11% of patients with neurofibromatosis type-1 (NF1) harbour large deletions encompassing the NF1 gene and flanking regions. These NF1 ...
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The bovine foot skin microbiota is associated with host genotype and the development of infectious digital dermatitis lesions
BackgroundBovine Digital Dermatitis (BDD) is a prevalent infectious disease, causing painful foot skin lesions and lameness in cattle. We describe...
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Role of Copolymers in Lung Cancer
Hydrogels, micelles, dendrimers, simple and functionalized nanoparticles, mesoporous particles, and liposomes have all been used effectively to...
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Myelination
Myelination is the process of generating myelin by Schwann cells in the peripheral nervous system (PNS) and oligodendrocytes (OL) in the central...
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Heterogeneity and Molecular Markers for CNS Glial Cells Revealed by Single-Cell Transcriptomics
Glial cells, including astrocytes, oligodendrocytes, and microglia, are the major components in the central nervous system (CNS). Studies have...
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Myelination
Myelination is the process of generating myelin by Schwann cells in the peripheral nervous system (PNS) and oligodendrocytes (OL) in the central...
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Identification of significant genes as prognostic markers and potential tumor suppressors in lung adenocarcinoma via bioinformatical analysis
BackgroundLung adenocarcinoma (LAC) is the predominant histologic subtype of lung cancer and has a complicated pathogenesis with high mortality. The...
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Molecular Tools for Characterizing AMR Pathogens
Antimicrobial resistance in bacterial pathogens is growing at a rapid pace. The problem of AMR has percolated to different sectors. The first and...
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Molecular Tools for Characterizing AMR Pathogens
Antimicrobial resistance in bacterial pathogens is growing at a rapid pace. The problem of AMR has percolated to different sectors. The first and...
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Cerebral White Matter Alterations Associated With Oligodendrocyte Vulnerability in Organic Acidurias: Insights in Glutaric Aciduria Type I
The white matter is an important constituent of the central nervous system, containing axons, oligodendrocytes, and its progenitor cells, astrocytes,...
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Comprehensive profiling and characterization of cellular microRNAs in response to coxsackievirus A10 infection in bronchial epithelial cells
Coxsackievirus A10 (CV-A10), the causative agent of hand, foot, and mouth disease (HFMD), caused a series of outbreaks in recent years and often...
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Genomic diversity and antimicrobial resistance of Campylobacter spp. from humans and livestock in Nigeria
BackgroundCampylobacter spp. are zoonotic pathogens, ubiquitous and are found naturally as commensals in livestock from where they can be...
