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Molecular and genetic characterization of human cell lines resistant tol-asparaginase and albizziin
Human cell lines resistant to l -asparaginase or albizziin were isolated by multistep selection of HT1080 fibrosarcoma and MIA PaCa-2 pancreatic...
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Recent progress toward reducing the use of animal experimentation in biomedical research
Before I begin to address the subject of this article, some background points need to be made, so that the reader can evaluate my role in this...
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The human tyrosine hydroxylase gene
1. Tyrosine hydroxylase (TH) is a rate-limiting enzyme for catecholamine biosynthesis, and it is a pterin-requiring monooxygenase. Both cDNAs and...
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Chromosomal localization of human aspartate aminotransferase genes by in situ hybridization
The localization of the human genes for cytosolic and mitochondrial aspartate aminotransferase (AspAT) has been determined by chromosomal in situ...
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Fast-twitch and slow-twitch/cardiac Ca2+ ATPase genes map to human chromosomes 16 and 12
The fast-twitch and slow-twitch/cardiac Ca 2+ ATPase genes have been assigned to human chromosomes 16 and 12, respectively, using rodent-human somatic...
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Nucleotide sequence of a cDNA coding for mitochondrial fumarase from human liver
The nucleotide sequence of a 1.46 kb cDNA, selected from a human liver library by the expression of fumarase antigenic determinants, was determined...
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Biochemical and genetic characterization of l-glutamate transport and utilization in Salmonella typhimurium LT-2 mutants
Two systems for l -glutamate transport were found in Salmonella typhimurium LT-2 GltU + (glutamate utilization) mutants. The first one is similar to...
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Assignment of human gene encoding thymidylate synthase to chromosome 18 using interspecific cell hybrids between thymidylate synthase-Negative mouse mutant cells and human diploid fibroblasts
We have constructed interspecific somatic cell hybrids between a thymidineauxotrophic mutant cell line of mouse FM3A cells that lacks thymidylate...
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Nierenfunktion
Die Nieren weisen eine Rinden- und eine Markregion auf. Sie bestehen beim Menschen aus jeweils 8–10 pyramidenförmigen Lappen, deren Spitzen als...
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X-linked dominant inherited diseases with lethality in hemizygous males
X-linked dominant inheritance with lethality in hemizygous males is a rare mode of inheritance. The three best-known disorders which seem to be...
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The Use of Staphylococcal Protein A in Diagnostic Virology
Staphylococcal protein A (SPA), a protein component of the cell wall of Staphylococcus aureus, binds the Fc portion of many immunoglobulins of most...
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Genetic Variants of Cultured Animal Cells
It has been clear for a number of years that the functional analysis of biological systems is highly dependent upon the availability of a large...
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Peptidasen
Using fresh frozen (with and without semipermeable membranes), freeze-dried or sections from aldehyde fixed material and hexazotized p-rosaniline for...
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Assignment of a human gene for tryptophanyl-tRNA synthetase to chromosome 14 using human-mouse somatic cell hybrids
Human tryptophanyl-tRNA synthetase (Trp-RS, EC 6.1.1.2) can be separated from its mouse counterpart by Cellogel electrophoresis. Analysis of the...
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Carcinofetale Antigene
CEA is a beta 1 -glycoprotein (mol. w. approx. 200 000) which in embryonic life is usually found as a cell membrane associated antigen in the...
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The Pea
Experimental evidence has shown that all forms of peas previously described as species have a diploid chromosome number of 14, that no sterility...
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Versuch zur Induktion einer immunologischen Toleranz gegen Pferde-IgG am Menschen
As a trial to induce immunological unresponsiveness to horse-IgG, 6 patients received two intravenous injections of the ultracentrifuged serum...
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Synthetische Polypeptide mit physiologischer Wirkung
In den letzten 10–15 Jahren sind viele Polypeptide mit physiologischer Wirkung strukturell aufgeklärt worden. Die Aminosäuresequenzen1 solcher...
