Abiotic Recombination

• Cech TR (1986) A model for the RNA-catalyzed replication of RNA. Proc Natl Acad Sci U S A 83(12):4360–4363

  Article  ADS  Google Scholar 

• Chen X, Li N, Ellington AD (2007) Ribozyme catalysis of metabolism in the RNA world. Chem Biodivers 4(4):633–655

  Article  Google Scholar 

• Ellington AD, Szostak JW (1990) In vitro selection of RNA molecules that bind specific ligands. Nature 346(6287):818–822

  Article  ADS  Google Scholar 

• Gilbert W (1986) Origin of life: the RNA world. Nature 319:618

  Article  ADS  Google Scholar 

• Hayden EJ, Riley CA, Burton AS, Lehman N (2005) RNA-directed construction of structurally complex and active ligase ribozymes through recombination. RNA 11:1678–1687

  Article  Google Scholar 

• Kruger K, Grabowski PJ, Zaug AJ, Sands J, Gottschling DE, Cech TR (1982) Self-splicing RNA: autoexcision and autocyclization of the ribosomal RNA intervening sequence of Tetrahymena. Cell 31(1):147–157

  Article  Google Scholar 

• Lohrmann R, Bridson PK, Orgel LE (1980) Efficient metal-ion catalyzed template-directed oligonucleotide synthesis. Science 208:1464–1465

  Article  ADS  Google Scholar 

• Meyer AJ, Ellefson JW, Ellington AD (2012) Abiotic self-replication. Acc Chem Res 45(12):2097–2105

  Article  Google Scholar 

• Nissen P, Hansen J, Ban N, Moore PB, Steitz TA (2000) The structural basis of ribosome activity in peptide bond synthesis. Science 289(5481):920–930

  Article  ADS  Google Scholar 

• Pino S, Ciciriello F, Costanzo G, Di Mauro E (2008) Nonenzymatic RNA ligation in water. J Biol Chem 283(52):36494–36503

  Article  Google Scholar 

• Pino S, Biasiucci M, Scardamaglia M, Gigli G, Betti MG, Mariani C, Di Mauro E (2011a) Nonenzymatic ligation of an RNA oligonucleotide analyzed by atomic force microscopy. J Phys Chem B 115(19):6296–6303

  Article  Google Scholar 

• Pino S, Costanzo G, Giorgi A, Di Mauro E (2011b) Sequence complementarity-driven nonenzymatic ligation of RNA. Biochemistry 50(14):2994–3003

  Article  Google Scholar 

• Pino S, Costanzo G, Giorgi A, Šponer J, Šponer JE, Di Mauro E (2013) Ribozyme activity of RNA nonenzymatically polymerized from 3′,5′-cyclic GMP. Entropy 15:5362–5383

  Article  ADS  Google Scholar 

• Riley CA, Lehman N (2003) Generalized RNA-directed recombination of RNA. Chem Biol 10(12):1233–1243

  Article  Google Scholar 

• Smail BA, Clifton BE, Mizuuchi R, Lehman N (2019) Spontaneous advent of genetic diversity in RNA populations through multiple recombination mechanisms. RNA 25(4):453–464

  Article  Google Scholar 

• Šponer JE, Šponer J, Novfflkovffl O, Brabec V, Sedo O, Zdrfflhal Z, Costanzo G, Pino S, Saladino R, Di Mauro E (2016) Emergence of the first catalytic oligonucleotides in a Formamide-based origin scenario. Chemistry 22(11):3572–3586

  Article  Google Scholar 

• Staroseletz Y, Nechaev S, Bichenkova E, Bryce RA, Watson C, Vlassov V, Zenkova M (2018) Non-enzymatic recombination of RNA: ligation in loops. Biochim Biophys Acta Gen Subj 1862(3):705–725

  Article  Google Scholar 

• Tuerk C, Gold L (1990) Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. Science 249(4968):505–510

  Article  ADS  Google Scholar 

• Yadav M, Kumar R, Krishnamurthy R (2020) Chemistry of abiotic nucleotide synthesis. Chem Rev 120(11):4766–4805

  Article  Google Scholar 

Download references