Coenzyme Q10 Ameliorates Neurodegeneration, Mossy Fiber Sprouting, and Oxidative Stress in Intrahippocampal Kainate Model of Temporal Lobe Epilepsy in Rat

• Abdin AA, Hamouda HE (2008) Mechanism of the neuroprotective role of coenzyme Q10 with or without L-dopa in rotenone-induced parkinsonism. Neuropharmacology 55:1340–1346

  Article  PubMed  CAS  Google Scholar 

• Baluchnejadmojarad T, Roghani M (2011) Chronic epigallocatechin-3-gallate ameliorates learning and memory deficits in diabetic rats via modulation of nitric oxide and oxidative stress. Behav Brain Res 224:305–310

  Article  PubMed  CAS  Google Scholar 

• Ben-Ari Y, Cossart R (2000) Kainate, a double agent that generates seizures: two decades of progress. Trends Neurosci 23:580–587

  Article  PubMed  CAS  Google Scholar 

• Bonakdar RA, Guarneri E (2005) Coenzyme Q10. Am Fam Physician 72:1065–1070

  PubMed  Google Scholar 

• Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248–254

  Article  PubMed  CAS  Google Scholar 

• Chuang YC, Chen SD, Liou CW, Lin TK, Chang WN, Chan SH et al (2009) Contribution of nitric oxide, superoxide anion, and peroxynitrite to activation of mitochondrial apoptotic signaling in hippocampal CA3 subfield following experimental temporal lobe status epilepticus. Epilepsia 50:731–746

  Article  PubMed  CAS  Google Scholar 

• Ciceri P, Zhang Y, Shaffer AF, Leahy KM, Woerner MB, Smith WG et al (2002) Pharmacology of celecoxib in rat brain after kainate administration. J Pharmacol Exp Ther 302:846–852

  Article  PubMed  CAS  Google Scholar 

• Curia G, Longo D, Biagini G, Jones RS, Avoli M (2008) The pilocarpine model of temporal lobe epilepsy. J Neurosci Methods 172:143–157

  Article  PubMed  CAS  Google Scholar 

• Dichter MA (2006) Models of epileptogenesis in adult animals available for antiepileptogenesis drug screening. Epilepsy Res 68:31–35

  Article  PubMed  Google Scholar 

• Jokeit H, Schacher M (2004) Neuropsychological aspects of type of epilepsy and etiological factors in adults. Epilepsy Behav 5(Suppl 1):S14–S20

  Article  PubMed  Google Scholar 

• Jourquin J, Tremblay E, Decanis N, Charton G, Hanessian S, Chollet AM et al (2003) Neuronal activity-dependent increase of net matrix metalloproteinase activity is associated with MMP-9 neurotoxicity after kainate. Eur J Neurosci 18:1507–1517

  Article  PubMed  Google Scholar 

• Karoly N, Mihaly A, Dobo E (2011) Comparative immunohistochemistry of synaptic markers in the rodent hippocampus in pilocarpine epilepsy. Acta Histochem 113:656–662

  Article  PubMed  CAS  Google Scholar 

• Kroemer G, Reed JC (2000) Mitochondrial control of cell death. Nat Med 6:513–519

  Article  PubMed  CAS  Google Scholar 

• Littarru GP, Tiano L (2007) Bioenergetic and antioxidant properties of coenzyme Q10: recent developments. Mol Biotechnol 37:31–37

  Article  PubMed  CAS  Google Scholar 

• Liu CH, Lin YW, Tang NY, Liu HJ, Hsieh CL (2012) Neuroprotective effect of Uncaria rhynchophylla in kainic acid-induced epileptic seizures by modulating hippocampal mossy fiber sprouting, neuron survival, astrocyte proliferation, and S100B expression. Evid Based Complement Alternat Med 2012:194790

  PubMed  Google Scholar 

• Loscher W (2002) Animal models of epilepsy for the development of antiepileptogenic and disease-modifying drugs. A comparison of the pharmacology of kindling and post-status epilepticus models of temporal lobe epilepsy. Epilepsy Res 50:105–123

  Article  PubMed  CAS  Google Scholar 

• Loscher W, Schmidt D (2006) New horizons in the development of antiepileptic drugs: innovative strategies. Epilepsy Res 69:183–272

  Article  PubMed  Google Scholar 

• Mancuso M, Orsucci D, Volpi L, Calsolaro V, Siciliano G (2010) Coenzyme Q10 in neuromuscular and neurodegenerative disorders. Curr Drug Targets 11:111–121

  Article  PubMed  CAS  Google Scholar 

• Mulle C, Sailer A, Perez-Otano I, Dickinson-Anson H, Castillo PE, Bureau I et al (1998) Altered synaptic physiology and reduced susceptibility to kainate-induced seizures in GluR6-deficient mice. Nature 392:601–605

  Article  PubMed  CAS  Google Scholar 

• Orsucci D, Mancuso M, Ienco EC, LoGerfo A, Siciliano G (2011) Targeting mitochondrial dysfunction and neurodegeneration by means of coenzyme Q10 and its analogues. Curr Med Chem 18:4053–4064

  Article  PubMed  CAS  Google Scholar 

• Papucci L, Schiavone N, Witort E, Donnini M, Lapucci A, Tempestini A et al (2003) Coenzyme Q10 prevents apoptosis by inhibiting mitochondrial depolarization independently of its free radical scavenging property. J Biol Chem 278:28220–28228

  Article  PubMed  CAS  Google Scholar 

• Paxinos G, Watson C (1986) The rat brain in stereotaxic coordinates. 2nd ed., Academic, San Diego.

• Racine R, Okujava V, Chipashvili S (1972) Modification of seizure activity by electrical stimulation. 3. Mechanisms. Electroencephalogr Clin Neurophysiol 32:295–299

  Article  PubMed  CAS  Google Scholar 

• Rauscher FM, Sanders RA, Watkins JB 3rd (2001) Effects of coenzyme Q10 treatment on antioxidant pathways in normal and streptozotocin-induced diabetic rats. J Biochem Mol Toxicol 15:41–46

  Article  PubMed  CAS  Google Scholar 

• Roghani M, Baluchnejadmojarad T (2009) Chronic epigallocatechin-gallate improves aortic reactivity of diabetic rats: underlying mechanisms. Vascul Pharmacol 51:84–89

  Article  PubMed  CAS  Google Scholar 

• Russo R, Cavaliere F, Rombola L, Gliozzi M, Cerulli A, Nucci C et al (2008) Rational basis for the development of coenzyme Q10 as a neurotherapeutic agent for retinal protection. Prog Brain Res 173:575–582

  Article  PubMed  CAS  Google Scholar 

• Sandhu JK, Pandey S, Ribecco-Lutkiewicz M, Monette R, Borowy-Borowski H, Walker PR et al (2003) Molecular mechanisms of glutamate neurotoxicity in mixed cultures of NT2-derived neurons and astrocytes: protective effects of coenzyme Q10. J Neurosci Res 72:691–703

  Article  PubMed  CAS  Google Scholar 

• Schmelzer C, Lindner I, Rimbach G, Niklowitz P, Menke T, Doring F (2008) Functions of coenzyme Q10 in inflammation and gene expression. Biofactors 32:179–183

  Article  PubMed  CAS  Google Scholar 

• Sharma AK, Reams RY, Jordan WH, Miller MA, Thacker HL, Snyder PW (2007) Mesial temporal lobe epilepsy: pathogenesis, induced rodent models and lesions. Toxicol Pathol 35:984–999

  Article  PubMed  Google Scholar 

• Shetty AK, Hattiangady B (2007) Restoration of calbindin after fetal hippocampal CA3 cell grafting into the injured hippocampus in a rat model of temporal lobe epilepsy. Hippocampus 17:943–956

  Article  PubMed  Google Scholar 

• Shin EJ, Ko KH, Kim WK, Chae JS, Yen TP, Kim HJ et al (2008) Role of glutathione peroxidase in the ontogeny of hippocampal oxidative stress and kainate seizure sensitivity in the genetically epilepsy-prone rats. Neurochem Int 52:1134–1147

  Article  PubMed  CAS  Google Scholar 

• Sperk G (1994) Kainic acid seizures in the rat. Prog Neurobiol 42:1–32

  Article  PubMed  CAS  Google Scholar 

• Stefan H, Lopes da Silva FH, Loscher W, Schmidt D, Perucca E, Brodie MJ et al (2006) Epileptogenesis and rational therapeutic strategies. Acta Neurol Scand 113:139–155

  Article  PubMed  CAS  Google Scholar 

• Tawfik MK (2011) Coenzyme Q10 enhances the anticonvulsant effect of phenytoin in pilocarpine-induced seizures in rats and ameliorates phenytoin-induced cognitive impairment and oxidative stress. Epilepsy Behav 22:671–677

  Article  PubMed  Google Scholar 

• Won R, Lee KH, Lee BH (2011) Coenzyme Q10 protects neurons against neurotoxicity in hippocampal slice culture. Neuroreport 22:721–726

  Article  PubMed  CAS  Google Scholar 

• Wu Z, Xu Q, Zhang L, Kong D, Ma R, Wang L (2009) Protective effect of resveratrol against kainate-induced temporal lobe epilepsy in rats. Neurochem Res 34:1393–1400

  Article  PubMed  CAS  Google Scholar 

• Yalcin A, Kilinc E, Kocturk S, Resmi H, Sozmen EY (2004) Effect of melatonin cotreatment against kainic acid on coenzyme Q10, lipid peroxidation and Trx mRNA in rat hippocampus. Int J Neurosci 114:1085–1097

  Article  PubMed  CAS  Google Scholar 

• Yang L, Calingasan NY, Wille EJ, Cormier K, Smith K, Ferrante RJ et al (2009) Combination therapy with coenzyme Q10 and creatine produces additive neuroprotective effects in models of Parkinson’s and Huntington’s diseases. J Neurochem 109:1427–1439

  Article  PubMed  CAS  Google Scholar 

• Young AJ, Johnson S, Steffens DC, Doraiswamy PM (2007) Coenzyme Q10: a review of its promise as a neuroprotectant. CNS Spectr 12:62–68

  PubMed  Google Scholar 

Download references