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ABA 8′-hydroxylase and its chemical inhibitors

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Abstract

Abscisic acid (ABA) regulates many important processes in normal growth and development as well as in adaptive responses to environmental stresses. For correct and accurate actions, physiologically active ABA level is controlled through fine-tuning of de novo biosynthesis and catabolism. Hydroxylation at the 8′-position of ABA is the key step in the oxidative catabolism of ABA, and this reaction is catalyzed by ABA 8′-hydroxylase, a cytochrome P450 (P450). Recently, the CYP707A family of Arabidopsis has been identified as ABA 8′-hydroxylase through genomic and biochemical approaches. The CYP707A family is present in a wide range of plant kingdom and functions in ABA catabolism in plants. CYP707A is the pivotal enzyme controlling the endogenous ABA levels by its transcriptional regulation and plays a key role in ABA-mediated physiological processes such as seed dormancy and stress response. Specific inhibitors of ABA catabolism can manipulate ABA homeostasis in plants and are potentially very useful tools for cellular and molecular investigations in the field of plant physiology as well as for potential agricultural chemicals. Identification of the ABA catabolic genes gives us new insight into the development of chemical inhibitors specific to ABA 8′-hydroxylase.

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  1. Institute for Chemical Research, Kyoto University, Uji, Kyoto, 611-0011, Japan

    Masaharu Mizutani

  2. Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, Shizuoka, 422-8529, Japan

    Yasushi Todoroki

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  1. Masaharu Mizutani
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  2. Yasushi Todoroki
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Correspondence to Masaharu Mizutani.

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Mizutani, M., Todoroki, Y. ABA 8′-hydroxylase and its chemical inhibitors. Phytochem Rev 5, 385–404 (2006). https://doi.org/10.1007/s11101-006-9012-6

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  • DOI: https://doi.org/10.1007/s11101-006-9012-6

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