Summary
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1.
The purpose of the present study was to investigate the interaction between hydrogen sulfide (H2S) and carbon monoxide (CO) during recurrent febrile seizures (FS)
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2.
H2S and CO are important intra- and intercellular messengers, regulating various brain functions. Our recent studies showed that both of them alleviate the hippocampal damage induced by recurrent FS. In the present study, on a rat model of recurrent FS, we found that hydroxylamine (an inhibitor of cystathionine b-synthase, CBS) reduced CO level and downregulated heme oxygenase (HO-1) expression, while NaHS (a donor of H2S) elevated CO level and upregulated HO-1 expression. ZnPP-IX (an inhibitor of HO-1) decreased H2S formation and downregulated CBS expression, while hemin (which increases the production of endogenous CO) enhanced H2S formation and elevated CBS expression.
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3.
Our data demonstrate that endogenous H2S and CO are in synergy with each other in recurrent FS.
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Han, Y., Qin, J., Chang, X. et al. Hydrogen Sulfide and Carbon Monoxide Are in Synergy with Each Other in the Pathogenesis of Recurrent Febrile Seizures. Cell Mol Neurobiol 26, 101–107 (2006). https://doi.org/10.1007/s10571-006-8848-z
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DOI: https://doi.org/10.1007/s10571-006-8848-z