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IL-17 increased the production of vascular endothelial growth factor in rheumatoid arthritis synoviocytes

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Abstract

Interleukin-17 (IL-17) is a proinflammatory cytokine that is expressed in the synovium T cells of rheumatoid arthritis (RA). This cytokine is implicated in the inflammation and destruction of the joint. However, the role of IL-17 on the production of vascular endothelial factor (VEGF) important to synovial proliferation has still not been identified. In this study, we investigated the effect on cultured rheumatoid fibroblast-like synoviocytes (FLS) of the IL-17 on the production and expression of VEGF, which play an important role in angiogenesis in rheumatoid synovium. IL-17 increased the production of VEGF dose dependently and the mRNA expression of VEGF. These results suggest that IL-17 might influence angiogenesis in RA by up-regulating the expression of VEGF in rheumatoid FLS.

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Acknowledgements

This work was supported by a project grant from the Supported by grants from the Pusan National University Hospital Institute

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Authors and Affiliations

  1. Division of Rheumatology, Department of Internal Medicine, College of Medicine, Pusan National University, 1-10, Ami-Dong, Seo-Gu, Busan, South Korea

    J. H. Lee & S. I. Kim

  2. Pusan National University Hospital Institutes, Busan, South Korea

    S. Ryu

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  1. S. Ryu
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  2. J. H. Lee
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  3. S. I. Kim
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Correspondence to S. I. Kim.

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Ryu, S., Lee, J.H. & Kim, S.I. IL-17 increased the production of vascular endothelial growth factor in rheumatoid arthritis synoviocytes. Clin Rheumatol 25, 16–20 (2006). https://doi.org/10.1007/s10067-005-1081-1

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  • DOI: https://doi.org/10.1007/s10067-005-1081-1

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