Abstract
Histamine is one of the mediators involved in allergic reactions, during which histamine may be released from mast cells of “peripheral” tissues such as skin, upper airways and lung, in response to antigen-antibody reaction (e.g. in specifically sensitized patients). Histamine may also be liberated as a result of mechanical, thermal or chemical injuries of cells. Histamine may be bound to two types of receptors, HI and H2, according to the different pharmacological effects observed. In addition, both type and number of receptors differ from one organ (or tissue) to another in a given species. For example, histamine increases blood pressure in guinea pigs and rabbits since in these species H1-receptors (leading to vasoconstriction) predominate on large arterial vessels; in humans, cats and dogs, histamine decreases blood pressure (in these species, H1- and H2-receptors predominate on small arterial vessels).
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Reinberg, A.E. (1997). Chronopharmacology of H1-Receptor Antagonists: Experimental and Clinical Aspects (Allergic Diseases). In: Redfern, P.H., Lemmer, B. (eds) Physiology and Pharmacology of Biological Rhythms. Handbook of Experimental Pharmacology, vol 125. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-09355-9_21
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DOI: https://doi.org/10.1007/978-3-662-09355-9_21
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