Collection
Extracellular vesicles
- Submission status
- Closed
Extracellular vesicles (EVs) are a heterogeneous group of cell-derived vesicles mediating the intercellular crosstalk. These vesicles carry the bioactive cargo from the donor cells, such as nucleic acids, proteins, lipids, and metabolites, and transfer it to the recipient cells both locally and remotely, causing a change in their behavior. The release and composition of EVs is altered under pathological conditions, which can have a significant impact on the pathobiological processes. EVs can help in the adaptation of cells to the harsh environmental conditions as well as facilitate the remodeling of stroma. Researchers are unveiling the functions of EVs at a rapid pace in reproductive process, stem cell biology, and malignancy. A role of EVs in immune modulation and therapeutic resistance is also being investigated. Further, being a natural carrier of biomolecules and their easy modifiability to enhance cell-specific targeting and cellular uptake, EVs represent a useful candidate for the development of efficient drug delivery systems. EVs are also a useful resource for biomarker development to assist in disease diagnosis, predicting the disease status, and monitoring of the therapeutic responses.
In this collection, we welcome original research articles, review manuscripts, as well as short communications that highlight the role of EVs in ovarian biology and pathobiology, targeting of their biogenesis and functions for therapeutic gain, and their potential utility in biomarker development and as drug delivery systems.
Articles (8 in this collection)
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Metformin modifies plasma microbial-derived extracellular vesicles in polycystic ovary syndrome with insulin resistance
Authors (first, second and last of 11)
- Liping Hu
- Guolin Hong
- Yuqin Li
- Content type: Research
- Open Access
- Published: 02 July 2024
- Article: 136
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Enhancing angiogenesis and inhibiting apoptosis: evaluating the therapeutic efficacy of bone marrow mesenchymal stem cell-derived exosomes in a DHEA-induced PCOS mouse model
Authors
- Xiaojing Teng
- Zhiyi Wang
- Xiaolei Wang
- Content type: Research
- Open Access
- Published: 05 June 2024
- Article: 121
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Exosomes in diagnostic and therapeutic applications of ovarian cancer
Authors (first, second and last of 8)
- Dhaval Bhavsar
- Rajeswari Raguraman
- Rajagopal Ramesh
- Content type: Review
- Open Access
- Published: 25 May 2024
- Article: 113
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Human mesenchymal stem cells derived exosomes improve ovarian function in chemotherapy-induced premature ovarian insufficiency mice by inhibiting ferroptosis through Nrf2/GPX4 pathway
Authors (first, second and last of 7)
- Yuan Zhou
- Jinfa Huang
- Kaixian Deng
- Content type: Research
- Open Access
- Published: 15 April 2024
- Article: 80
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Corpus luteum presence in the bovine ovary increase intrafollicular progesterone concentration: consequences in follicular cells gene expression and follicular fluid small extracellular vesicles miRNA contents
Authors (first, second and last of 9)
- Paola Maria da Silva Rosa
- Alessandra Bridi
- Juliano Coelho da Silveira
- Content type: Research
- Open Access
- Published: 18 March 2024
- Article: 65
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Exosomal biomarkers in the differential diagnosis of ovarian tumors: the emerging roles of CA125, HE4, and C5a
Authors (first, second and last of 7)
- Huihui Shi
- Liya Liu
- Liping Han
- Content type: Research
- Open Access
- Published: 05 January 2024
- Article: 4
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Proteomic analysis of exosomes secreted during the epithelial-mesenchymal transition and potential biomarkers of mesenchymal high-grade serous ovarian carcinoma
Authors (first, second and last of 8)
- Germano Aguiar Ferreira
- Carolina Hassibe Thomé
- Francisco José Candido dos Reis
- Content type: Research
- Open Access
- Published: 29 November 2023
- Article: 232