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Functions of Rab GTPases in organelle biogenesis

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Regulatory Mechanisms of Intracellular Membrane Transport

Part of the book series: Topics in Current Genetics ((TCG,volume 10))

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Abstract

Rab GTPases regulate diverse aspects of the biogenesis of secretory and endocytic organelles. The conformational changes that accompany GTP binding and hydrolysis by Rab are harnessed to recruit and activate specific effector proteins that regulate vesicle tethering and fusion, cargo sorting, and cytoskeleton-dependent organelle transport. We review recent progress in understanding how Rab GTPases are regulated and how they regulate membrane trafficking.

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  1. Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, 421 Curie Boulevard room 1010, Philadelphia, PA 19104-6158, USA

    Christopher G. Burd

  2. Department of Molecular Medicine, C4-109, VMC, Cornell University, Ithaca NY 14853-6401,  

    Ruth N. Collins

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Sirkka Keränen Jussi Jäntti

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Burd, C.G., Collins, R.N. Functions of Rab GTPases in organelle biogenesis. In: Keränen, S., Jäntti, J. (eds) Regulatory Mechanisms of Intracellular Membrane Transport. Topics in Current Genetics, vol 10. Springer, Berlin, Heidelberg. https://doi.org/10.1007/b97781

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