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Necroptosis and Its Involvement in Various Diseases

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Basic Immunology and Its Clinical Application

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1444))

Abstract

Necroptosis is a regulated form of cell death involved in the development of various pathological conditions. In contrast to apoptosis, plasma membrane rupture (PMR) occurs in cells in the relatively early stage of necroptosis; therefore, necroptosis induces a strong inflammatory response. Stimuli, including tumor necrosis factor (TNF), interferon (IFN)α/β, lipopolysaccharide, polyI:C, and viral infection, induce the formation of necrosomes that lead to membrane rupture and the release of intracellular contents, termed danger-associated molecular patterns (DAMPs). DAMPs are the collective term for molecules that normally reside in the cytoplasm or nucleus in living cells without inducing inflammation but induce strong inflammatory responses when released outside cells. Recent studies have provided a better understanding of the mechanisms underlying PMR and the release of DAMPs. Moreover, necroptosis is involved in various pathological conditions, and mutations in necroptosis-related genes can cause hereditary autoinflammatory syndromes. Thus, manipulating necroptosis signaling pathways may be useful for treating diseases involving necroptosis.

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Acknowledgments

This work was supported in part by Grants-in-Aid for Scientific Research (B) 20H03475 and 23H02707 (to HN) from the Japan Society for the Promotion of Science (JSPS) of the Japan Agency for Medical Research and Development (AMED) under Grant Number 22gm1210002 (to HN); the Ministry of Education, Culture, Sports, Science, and Technology, Japan, the Toho University Grant for Research Initiative Program (TUGRIP) (to HN); the Science Research Promotion Fund and The Promotion and Mutual Aid Corporation for Private Schools of Japan (to HN); and the Princess Takamatsu Cancer Research Grant (to HN).

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  1. Department of Biochemistry, Faculty of Medicine, Toho University School of Medicine, Tokyo, Japan

    Hiroyasu Nakano

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Correspondence to Hiroyasu Nakano .

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  1. Professor Emeritus, Tokushima University, Tokushima, Japan

    Mitsuru Matsumoto

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Nakano, H. (2024). Necroptosis and Its Involvement in Various Diseases. In: Matsumoto, M. (eds) Basic Immunology and Its Clinical Application. Advances in Experimental Medicine and Biology, vol 1444. Springer, Singapore. https://doi.org/10.1007/978-981-99-9781-7_9

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