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Global Approach for Drug Discovery and Development from Indian Traditional Medicine

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Evidence Based Validation of Traditional Medicines

Abstract

Traditional medicine is the fusion of therapeutic experiences of generations of general physicians, tribal and rural peoples of indigenous systems of medication. Medicinal plants play a crucial role for the investigation of new entities (biologically active compounds in the current market). Drug discovery approaches based on natural products and traditional medicines are re-emerging as choices for new drugs to facilitate discovery process and also for the development of synergistic herbal formulations. Moreover, the integration of Ayurvedic knowledge and drug discovery brings the need for a revolution in the extraction process from sequential to parallel extraction. Bioassay-guided fractionation is a supportive measure through which standardized extract or isolated bioactive compound is obtained as the new drug. This integrated approach would result in saving of cost, time, and increased success rate in drug discovery. In this chapter we exemplified various approaches of drug discovery and application of Ayurvedic opinion in preference of plant for its therapeutic (e.g., antidiabetic) activity.

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Abbreviations

GMP:

Good Manufacturing Practice

GCP:

Good Clinical Practice

GLP:

Good Laboratory Practice

CMC:

Chemistry, Manufacturing and Controls

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Correspondence to Shanti Bhushan Mishra .

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Mishra, S.B., Mukerjee, A., Singh, S. (2021). Global Approach for Drug Discovery and Development from Indian Traditional Medicine. In: Mandal, S.C., Chakraborty, R., Sen, S. (eds) Evidence Based Validation of Traditional Medicines. Springer, Singapore. https://doi.org/10.1007/978-981-15-8127-4_1

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