Abstract
Traditional medicine is the fusion of therapeutic experiences of generations of general physicians, tribal and rural peoples of indigenous systems of medication. Medicinal plants play a crucial role for the investigation of new entities (biologically active compounds in the current market). Drug discovery approaches based on natural products and traditional medicines are re-emerging as choices for new drugs to facilitate discovery process and also for the development of synergistic herbal formulations. Moreover, the integration of Ayurvedic knowledge and drug discovery brings the need for a revolution in the extraction process from sequential to parallel extraction. Bioassay-guided fractionation is a supportive measure through which standardized extract or isolated bioactive compound is obtained as the new drug. This integrated approach would result in saving of cost, time, and increased success rate in drug discovery. In this chapter we exemplified various approaches of drug discovery and application of Ayurvedic opinion in preference of plant for its therapeutic (e.g., antidiabetic) activity.
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Abbreviations
- GMP:
-
Good Manufacturing Practice
- GCP:
-
Good Clinical Practice
- GLP:
-
Good Laboratory Practice
- CMC:
-
Chemistry, Manufacturing and Controls
References
Alam F, Shafique Z, Amjad ST, BinAsad MHH (2019) Enzymes inhibitors from natural sources with anti-diabetic activity: a review. Phytother Res 33:41–54
Alamgir ANM (2017) Drugs: their natural, synthetic, and biosynthetic sources. In: Therapeutic use of medicinal plants and their extracts, volume 1. Progress in drug research, vol 73. Springer, Cham
Albuquerque UP, Ramos MA, Melo JG (2012) New strategies for drug discovery in tropical forests based on ethnobotanical and chemical ecological studies. J Ethnopharmacol 140:197–201
Altemimi A, Lakhssassi N, Baharlouei A, Watson DG, Lightfoot DA (2017) Phytochemicals: extraction, isolation, and identification of bioactive compounds from plant extracts. Plants (Basel, Switzerland) 6(4):42. https://doi.org/10.3390/plants6040042
Atanasov AG, Waltenberger B, Pferschy-Wenzig EM, Linder T, Wawrosch C, Uhrin P et al (2015) Discovery and resupply of pharmacologically active plant-derived natural products: a review. Biotechnol Adv 33(8):1582–1614. https://doi.org/10.1016/j.biotechadv.2015.08.001
Baker JT, Borris RP, Carte B, Cordell GA, Soejarto DD, Cragg GM et al (1995) Natural product drug discovery and development: new perspectives on international collaboration. J Nat Prod 58:1325–1357
Bergström C, Larsson P (2018) Computational prediction of drug solubility in water-based systems: qualitative and quantitative approaches used in the current drug discovery and development setting. Int J Pharm 540(1–2):185–193. https://doi.org/10.1016/j.ijpharm.2018.01.044
Bierer DE, Fort DM, Mendez CD, Luo J, Imbach PA, Dubenko LG et al (1998) Ethnobotanical -directed discovery of the anti-hyperglycemic properties of Cryptolepine: its isolation from Cryptolepis sanguinolenta, synthesis and its in vitro and in vivo activities. J Med Chem 41:894–901
Chung TDY, Terry DB, Smith LH (2015) In vitro and in vivo assessment of ADME and PK properties during lead selection and lead optimization—guidelines, benchmarks and rules of thumb. In: Sittampalam GS, Grossman A, Brimacombe K et al (eds) Assay guidance manual. Eli Lilly & Company and the National Center for Advancing Translational Sciences, Bethesda, MD. https://www.ncbi.nlm.nih.gov/books/NBK326710/
Coley PD, Heller MV, Aizprua R, Araúz B, Flores N, Correa M et al (2003) Using ecological criteria to design plant collection strategies for drug discovery. Front Ecol Environ 1:421–428
de Almeida CFCBR, de Amorim ELC, de Albuquerque UP (2011) Insights into search for new drugs from traditional knowledge: an ethnobotanical and chemical-ecological perspective. Pharm Biol 49:864–873
Dias DA, Urban S, Roessner U (2012) A historical overview of natural products in drug discovery. Metabolites 2(2):303–336. https://doi.org/10.3390/metabo2020303
Do QT, Renimel I, Andre P, Lugnier C, Muller CD, Bernard P (2005) Reverse pharmacognosy: application of Selnergy, a new tool for lead discovery. The example of ε-viniferin. Curr Drug Discov Technol 2:1–7
Harvey AL (2008) Natural products in drug discovery. Drug Discov Today 13:894–901
Hefti FF (2008) Requirements for a lead compound to become a clinical candidate. BMC Neurosci 9(Suppl 3):S7. https://doi.org/10.1186/1471-2202-9-S3-S7
Jadavaji T (ed) (1992) Charaka Samhita. Chaukhamba Surbharati Prakashan, Varanasi
Jamshidi-Kia F, Lorigooini Z, Amini-Khoei H (2018) Medicinal plants: past history and future perspective. J Herbmed Pharmacol 7(1):1–7. https://doi.org/10.15171/jhp.2018.01
Kansy M, Avdeef A, Fischer H (2004) Advances in screening for membrane permeability: high-resolution PAMPA for medicinal chemists. Drug Discov Today Technol 1(4):349–355. https://doi.org/10.1016/j.ddtec.2004.11.013
Koehn FE, Carter GT (2005) The evolving role of natural products in drug discovery. Nat Rev Drug Discov 4:206–220
Kumar S, Dobos GJ, Rampp T (2017) The significance of ayurvedic medicinal plants. J Evid Based Complement Alternat Med 22(3):494–501. https://doi.org/10.1177/2156587216671392
Lewis WH (2003) Pharmaceutical discoveries based on ethnomedicinal plants: 1985 to 2000 and beyond. Econ Bot 57:126–134
López-Vallejo F, Caulfield T, Martínez-Mayorga K, Giulianotti MA, Nefzi A, Houghten RA et al (2011) Integrating virtual screening and combinatorial chemistry for accelerated drug discovery. Comb Chem High Throughput Screen 14:475–487
Luo J, Fort DM, Carlson TJ, Noamesi BK, nii-Amon-Kotei D, King SR et al (1998) Cryptolepis sanguinolenta: an ethnobotanical approach to drug discovery and the isolation of a potentially useful new anti-hyperglycaemic agent. Diabet Med 15:367–374
Mishra SB, Rao CV, Ojha SK, Vijayakumar M, Verma A, Alok S (2010) An analytical review of plants for anti diabetic activity with their phyto-constituents & mechanism of action. Int J Pharm Sci Res 1(1):29–46
Modak M, Dixit P, Londhe J, Ghaskadbi S, Devasagayam TP (2007) Indian herbs and herbal drugs used for the treatment of diabetes. J Clin Biochem Nutr 40(3):163–173. https://doi.org/10.3164/jcbn.40.163
Obbo CJD, Makanga B, Mulholland DA, Coombes PH, Brun R (2013) Antiprotozoal activity of Khaya anthotheca (Welv.) C.D.C. a plant used by chimpanzees for self medication. J Ethnopharmacol 147:220–223
Pan SY, Zhou SF, Gao SH, Yu ZL, Zhang SF, Tang MK (2013) New perspectives on how to discover drugs from herbal medicines: CAM’s outstanding contribution to modern therapeutics. Evid Based Complement Alternat Med 2013:627375. https://doi.org/10.1155/2013/627375
Ramesha BT, Gertsch J, Ravikanth G, Priti V, Ganeshaiah KN, Shaanker RU (2011) Biodiversity and chemodiversity: future perspectives in bioprospecting. Curr Drug Targets 12:1515–1530
Sen S, Chakraborty R (2016) Revival, modernization and integration of Indian traditional herbal medicine in clinical practice: importance, challenges and future. J Trad Complement Med 7(2):234–244. https://doi.org/10.1016/j.jtcme.2016.05.006
Sharma PV (ed) (2001) Sushruta Samhita. Chaukhamba Vishwabharati, Varanasi
Sharma H, Chandola HM (2011) Prameha in ayurveda: correlation with obesity, metabolic syndrome, and diabetes mellitus. Part 1–etiology, classification, and pathogenesis. J Altern Complement Med 17(6):491–496. https://doi.org/10.1089/acm.2010.0396
Srikantha Murty KR (ed) (2000) Astanga Hridaya. Krishnadas Academy, Varanasi
Zhang Q (2015) Traditional and complementary medicine in primary health care. In: Medcalf A, Bhattacharya S, Momen H et al (eds) Health for all: the journey of universal health coverage. Orient Blackswan, Hyderabad. https://www.ncbi.nlm.nih.gov/books/NBK316267/
Zhu F, Ma XH, Qin C, Tao L, Liuy X, Shi Z et al (2012) Drug discovery prospect from untapped species: indicators from approved natural product drugs. PLoS One 7:e39782. https://doi.org/10.1371/journal.pone.0039782
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Mishra, S.B., Mukerjee, A., Singh, S. (2021). Global Approach for Drug Discovery and Development from Indian Traditional Medicine. In: Mandal, S.C., Chakraborty, R., Sen, S. (eds) Evidence Based Validation of Traditional Medicines. Springer, Singapore. https://doi.org/10.1007/978-981-15-8127-4_1
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