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Compartmentalization of Synaptic Tagging and Capture

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Synaptic Tagging and Capture

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Abstract

Testing of the synaptic tagging and capture (STC) hypothesis has produced remarkable work on the understanding of how a single neuron undergoes spatial and temporal encoding of information. Central to this work is the notion that STC processes can be compartment specific. Formed by activation of synaptic plasticity mechanisms and extending along confined dendritic domains, these compartments can work as the neuron’s information integration units. The association or dismissal of incoming information would depend on the plasticity-driven functional state of the compartment. With multiple streams of neural activity arriving at distinct synapses in a neuron, compartmentalization emerges as a key strategy to organize this information and enhance the neuron’s computing capability.

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Acknowledgments

Thanks to Ms. Bridget Curran, Ms. Denise Leggard, Prof. Kim Allen, and Prof. Todd Sacktor for extremely helpful comments. J.M.A. is supported by the National Institutes of Health (NIH) NS08162501A1.

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  1. Department of Pathology, The Robert F. Furchgott Center for Neural and Behavioral Science, State University of New York, Downstate Medical Center, Brooklyn, NY, USA

    Juan Marcos Alarcon

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Correspondence to Juan Marcos Alarcon .

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  1. Physiology and Health Longevity, National University of Singapore, Kent Ridge, Singapore

    Sreedharan Sajikumar

  2. Iowa Neuroscience Institute, University of Iowa, Iowa City, IA, USA

    Ted Abel

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Alarcon, J.M. (2024). Compartmentalization of Synaptic Tagging and Capture. In: Sajikumar, S., Abel, T. (eds) Synaptic Tagging and Capture. Springer, Cham. https://doi.org/10.1007/978-3-031-54864-2_7

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