Abstract
Long-term potentiation (LTP) at hippocampal synapses is classically triggered by the synaptic activation of NMDA receptors (NMDARs) and is expressed, at least in part, by an increase in the number of calcium-impermeable (CI)-AMPARs (CI-AMPARs). NMDARs confer “Hebbian” properties to this form of synaptic plasticity, including input specificity to the synapses receiving the induction stimulus. Synaptic tagging and capture (STC) is an important form of metaplasticity, that is, by definition, heterosynaptic in nature. As described in detail elsewhere in this volume, STC involves a “tag” to mark activated synapses and a “capture” mechanism to enable “tagged synapses” to induce a protein synthesis-dependent form of LTP. Here, we summarize our recent work that suggests calcium-permeable (CP)-AMPARs (CP-AMPARs) serve as the synaptic tag and also help trigger the de novo protein synthesis, by which synapses are “captured.”
Laura A. Koek and Pojeong Park are co-first authors.
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Acknowledgments
The authors would like to thank Richard Morris, Tim Bliss, and Sam Cooke for a series of enlightened discussions regarding the STC mechanism. G.L.C. is the holder of the Krembil Family Chair in Alzheimer’s Research, Supported by grants from CIHR (Canadian Institutes of Health Research) Foundation Grant #154276 (G.L.C.). L.K. was supported by an LTRI OSOTF (Ontario Student Opportunity Trust Fund) studentship.
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Koek, L.A. et al. (2024). Role of Calcium-Permeable AMPARs in Synaptic Tagging and Capture in the Rodent Hippocampus. In: Sajikumar, S., Abel, T. (eds) Synaptic Tagging and Capture. Springer, Cham. https://doi.org/10.1007/978-3-031-54864-2_2
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