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Hematopathology

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Pathology: Historical and Contemporary Aspects

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Abstract

Hematopathology is the study of diseases and disorders of the cells that make up the blood, bone marrow, spleen, and lymph nodes. The diagnoses of diseases such as lymphomas and leukemias are done by the hematopathologists. The history of leukemias extends back to more than 200 years. Splenitis acutus was described by Peter Cullen around 1811 [1]. Virchow described leukemia in 1847 based on his observations of the reversed white and red blood cell balance that he observed. He also described malignant lymphomas. Henry Fuller described the first leukemic patient based on microscopic observations. Abnormalities of lymph nodes with pathologic enlargement was observed around 1862 and follicular lymphoma, a low-grade, slow-growing variant of malignant lymphoma, was first recognized in 1925. It was initially thought to be a benign disorder, but was later shown with careful follow-up studies to be a low-grade malignancy [2]. Thomas Hodgkin first described Hodgkin’s disease without even using a microscope. Interestingly, some cases of Hodgkin’s disease were confused with tuberculosis around the time of Hodgkin and for many decades later. The studies of Dorothy Reed were able to separate Hodgkins disease from tuberculosis. Immunohistochemical, flow cytometric and molecular techniques have provided major advances in diagnostic hematopathology. Application of these techniques include flow cytometry analysis, immunoglobulin light chain restriction studies, B cell clonal restriction and gene rearrangement analyses.

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Authors and Affiliations

  1. Department of Pathology & Lab Medicine, University of Wisconsin–Madison, Madison, WI, USA

    Ricardo V. Lloyd

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  1. Ricardo V. Lloyd
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Lloyd, R.V. (2023). Hematopathology. In: Pathology: Historical and Contemporary Aspects. Springer, Cham. https://doi.org/10.1007/978-3-031-39554-3_14

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  • DOI: https://doi.org/10.1007/978-3-031-39554-3_14

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  • Publisher Name: Springer, Cham

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  • Online ISBN: 978-3-031-39554-3

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