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Endobronchial Ultrasound

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Interventions in Pulmonary Medicine

Abstract

Endobronchial ultrasound (EBUS) is a technology that utilizes the ability of high-frequency sound waves to pass through differing densities of tissue surrounding the airway lumen and produce a representative image. The properties of EBUS have expanded visualization from our previously limited view within the airway to beyond the airway wall. Radiologic imaging has proven to be unreliable in providing a definitive diagnosis of these structures and conventional bronchoscopic techniques lack the diagnostic yield and sensitivity to support their use. EBUS has provided pulmonologists with two platforms, convex probe endobronchial ultrasound (CP-EBUS) and radial probe ultrasound (RP-EBUS), that have changed the bronchoscopist’s practice and continues to pave the way for further advancement in pulmonology. This chapter will provide a detailed overview of the procedural details, clinical applications, and supporting data pertaining to RP-EBUS and CP-EBUS.

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References

  1. DiMagno EP, Buxton JL, Regan PT, Hattery RR, Wilson DA, Suarez JR, et al. Ultrasonic endoscope. Lancet. 1980;1(8169):629–31.

    CAS  PubMed  Google Scholar 

  2. Hurter T, Hanrath P. Endobronchial sonography: feasibility and preliminary results. Thorax. 1992;47(7):565–7.

    CAS  PubMed  PubMed Central  Google Scholar 

  3. Herth FJ, Ernst A, Becker HD. Endobronchial ultrasound-guided transbronchial lung biopsy in solitary pulmonary nodules and peripheral lesions. Eur Respir J. 2002;20(4):972–4.

    CAS  PubMed  Google Scholar 

  4. Yang H, Zhang Y, Wang KP, Ma Y. Transbronchial needle aspiration: development history, current status and future perspective. J Thorac Dis. 2015;7(Suppl 4):S279–86.

    PubMed  PubMed Central  Google Scholar 

  5. Vyas KS, Davenport DL, Ferraris VA, Saha SP. Mediastinoscopy: trends and practice patterns in the United States. South Med J. 2013;106(10):539–44.

    PubMed  PubMed Central  Google Scholar 

  6. Yasufuku K, Chiyo M, Sekine Y, Chhajed PN, Shibuya K, Iizasa T, et al. Real-time endobronchial ultrasound-guided transbronchial needle aspiration of mediastinal and hilar lymph nodes. Chest. 2004;126(1):122–8.

    PubMed  Google Scholar 

  7. Chao TY, Lie CH, Chung YH, Wang JL, Wang YH, Lin MC. Differentiating peripheral pulmonary lesions based on images of endobronchial ultrasonography. Chest. 2006;130(4):1191–7.

    PubMed  Google Scholar 

  8. Yasufuku K, T. F. Endobronchial ultrasound: indications, advantages, and complications. Waltham: UpToDate; 2012.

    Google Scholar 

  9. Kurimoto N, Murayama M, Yoshioka S, Nishisaka T. Analysis of the internal structure of peripheral pulmonary lesions using endobronchial ultrasonography. Chest. 2002;122(6):1887–94.

    PubMed  Google Scholar 

  10. Kuo CH, Lin SM, Chen HC, Chou CL, Yu CT, Kuo HP. Diagnosis of peripheral lung cancer with three echoic features via endobronchial ultrasound. Chest. 2007;132(3):922–9.

    PubMed  Google Scholar 

  11. Zhang HF, Zeng XT, Xing F, Fan N, Liao MY. The diagnostic accuracy of CT-guided percutaneous core needle biopsy and fine needle aspiration in pulmonary lesions: a meta-analysis. Clin Radiol. 2016;71(1):1–10.

    CAS  Google Scholar 

  12. Wiener RS, Schwartz LM, Woloshin S, Welch HG. Population-based risk for complications after transthoracic needle lung biopsy of a pulmonary nodule: an analysis of discharge records. Ann Intern Med. 2011;155(3):137–44.

    PubMed  PubMed Central  Google Scholar 

  13. Rivera MP, Mehta AC, Wahidi MM. Establishing the diagnosis of lung cancer: diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest. 2013;143(5 Suppl):142S–65S.

    Google Scholar 

  14. Paone G, Nicastri E, Lucantoni G, Dello Iacono R, Battistoni P, D’Angeli AL, et al. Endobronchial ultrasound-driven biopsy in the diagnosis of peripheral lung lesions. Chest. 2005;128(5):3551–7.

    PubMed  Google Scholar 

  15. Kikuchi E, Yamazaki K, Sukoh N, Kikuchi J, Asahina H, Imura M, et al. Endobronchial ultrasonography with guide-sheath for peripheral pulmonary lesions. Eur Respir J. 2004;24(4):533–7.

    CAS  PubMed  Google Scholar 

  16. Kurimoto N, Miyazawa T, Okimasa S, Maeda A, Oiwa H, Miyazu Y, et al. Endobronchial ultrasonography using a guide sheath increases the ability to diagnose peripheral pulmonary lesions endoscopically. Chest. 2004;126(3):959–65.

    PubMed  Google Scholar 

  17. Chao TY, Chien MT, Lie CH, Chung YH, Wang JL, Lin MC. Endobronchial ultrasonography-guided transbronchial needle aspiration increases the diagnostic yield of peripheral pulmonary lesions: a randomized trial. Chest. 2009;136(1):229–36.

    PubMed  Google Scholar 

  18. Yamada N, Yamazaki K, Kurimoto N, Asahina H, Kikuchi E, Shinagawa N, et al. Factors related to diagnostic yield of transbronchial biopsy using endobronchial ultrasonography with a guide sheath in small peripheral pulmonary lesions. Chest. 2007;132(2):603–8.

    PubMed  Google Scholar 

  19. Huang CT, Ho CC, Tsai YJ, Yu CJ, Yang PC. Factors influencing visibility and diagnostic yield of transbronchial biopsy using endobronchial ultrasound in peripheral pulmonary lesions. Respirology. 2009;14(6):859–64.

    PubMed  Google Scholar 

  20. Tay JH, Irving L, Antippa P, Steinfort DP. Radial probe endobronchial ultrasound: factors influencing visualization yield of peripheral pulmonary lesions. Respirology. 2013;18(1):185–90.

    PubMed  Google Scholar 

  21. Steinfort DP, Khor YH, Manser RL, Irving LB. Radial probe endobronchial ultrasound for the diagnosis of peripheral lung cancer: systematic review and meta-analysis. Eur Respir J. 2011;37(4):902–10.

    CAS  PubMed  Google Scholar 

  22. Wang Memoli JS, Nietert PJ, Silvestri GA. Meta-analysis of guided bronchoscopy for the evaluation of the pulmonary nodule. Chest. 2012;142(2):385–93.

    PubMed  Google Scholar 

  23. Asahina H, Yamazaki K, Onodera Y, Kikuchi E, Shinagawa N, Asano F, et al. Transbronchial biopsy using endobronchial ultrasonography with a guide sheath and virtual bronchoscopic navigation. Chest. 2005;128(3):1761–5.

    PubMed  Google Scholar 

  24. Ishida T, Asano F, Yamazaki K, Shinagawa N, Oizumi S, Moriya H, et al. Virtual bronchoscopic navigation combined with endobronchial ultrasound to diagnose small peripheral pulmonary lesions: a randomised trial. Thorax. 2011;66(12):1072–7.

    PubMed  Google Scholar 

  25. Eberhardt R, Anantham D, Ernst A, Feller-Kopman D, Herth F. Multimodality bronchoscopic diagnosis of peripheral lung lesions: a randomized controlled trial. Am J Respir Crit Care Med. 2007;176(1):36–41.

    PubMed  Google Scholar 

  26. Harley DP, Krimsky WS, Sarkar S, Highfield D, Aygun C, Gurses B. Fiducial marker placement using endobronchial ultrasound and navigational bronchoscopy for stereotactic radiosurgery: an alternative strategy. Ann Thorac Surg. 2010;89(2):368–73; discussion 73–4.

    PubMed  Google Scholar 

  27. Herth F, Ernst A, Schulz M, Becker H. Endobronchial ultrasound reliably differentiates between airway infiltration and compression by tumor. Chest. 2003;123(2):458–62.

    PubMed  Google Scholar 

  28. Irani S, Hess T, Hofer M, Gaspert A, Bachmann LM, Russi EW, et al. Endobronchial ultrasonography for the quantitative assessment of bronchial mural structures in lung transplant recipients. Chest. 2006;129(2):349–55.

    PubMed  Google Scholar 

  29. Soja J, Grzanka P, Sladek K, Okon K, Cmiel A, Mikos M, et al. The use of endobronchial ultrasonography in assessment of bronchial wall remodeling in patients with asthma. Chest. 2009;136(3):797–804.

    PubMed  Google Scholar 

  30. Sarkiss M. Anesthesia for bronchoscopy and interventional pulmonology: from moderate sedation to jet ventilation. Curr Opin Pulm Med. 2011;17(4):274–8.

    PubMed  Google Scholar 

  31. Rusch VW, Asamura H, Watanabe H, Giroux DJ, Rami-Porta R, Goldstraw P, et al. The IASLC lung cancer staging project: a proposal for a new international lymph node map in the forthcoming seventh edition of the TNM classification for lung cancer. J Thorac Oncol. 2009;4(5):568–77.

    PubMed  Google Scholar 

  32. Fujiwara T, Yasufuku K, Nakajima T, Chiyo M, Yoshida S, Suzuki M, et al. The utility of sonographic features during endobronchial ultrasound-guided transbronchial needle aspiration for lymph node staging in patients with lung cancer: a standard endobronchial ultrasound image classification system. Chest. 2010;138(3):641–7.

    PubMed  Google Scholar 

  33. Herth F, Becker HD, Ernst A. Conventional vs endobronchial ultrasound-guided transbronchial needle aspiration: a randomized trial. Chest. 2004;125(1):322–5.

    PubMed  Google Scholar 

  34. von Bartheld MB, Dekkers OM, Szlubowski A, Eberhardt R, Herth FJ, in’t Veen JC, et al. Endosonography vs conventional bronchoscopy for the diagnosis of sarcoidosis: the GRANULOMA randomized clinical trial. JAMA. 2013;309(23):2457–64.

    Google Scholar 

  35. Tremblay A, Stather DR, Maceachern P, Khalil M, Field SK. A randomized controlled trial of standard vs endobronchial ultrasonography-guided transbronchial needle aspiration in patients with suspected sarcoidosis. Chest. 2009;136(2):340–6.

    PubMed  Google Scholar 

  36. Agarwal R, Srinivasan A, Aggarwal AN, Gupta D. Efficacy and safety of convex probe EBUS-TBNA in sarcoidosis: a systematic review and meta-analysis. Respir Med. 2012;106(6):883–92.

    PubMed  Google Scholar 

  37. Wahidi MM, Herth F, Yasufuku K, Shepherd RW, Yarmus L, Chawla M, et al. Technical aspects of endobronchial ultrasound-guided transbronchial needle aspiration: CHEST guideline and expert panel report. Chest. 2016;149(3):816–35.

    PubMed  Google Scholar 

  38. Madan K, Mohan A, Ayub II, Jain D, Hadda V, Khilnani GC, et al. Initial experience with endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) from a tuberculosis endemic population. J Bronchol Interv Pulmonol. 2014;21(3):208–14.

    Google Scholar 

  39. Steinfort DP, Johnson DF, Connell TG, Irving LB. Endobronchial ultrasound-guided biopsy in the evaluation of intrathoracic lymphadenopathy in suspected tuberculosis: a minimally invasive technique with a high diagnostic yield. J Infect. 2009;58(4):309–11.

    PubMed  Google Scholar 

  40. Casal RF, Adachi R, Jimenez CA, Sarkiss M, Morice RC, Eapen GA. Diagnosis of invasive aspergillus tracheobronchitis facilitated by endobronchial ultrasound-guided transbronchial needle aspiration: a case report. J Med Case Rep. 2009;3:9290.

    PubMed  PubMed Central  Google Scholar 

  41. Steinfort DP, Irving LB. Endobronchial ultrasound staging of thyroid lesion in small cell lung carcinoma. Thorac Cardiovasc Surg. 2010;58(2):128–9.

    CAS  PubMed  Google Scholar 

  42. Casal RF, Phan MN, Keshava K, Garcia JM, Grosu H, Lazarus DR, et al. The use of endobronchial ultrasound-guided transbronchial needle aspiration in the diagnosis of thyroid lesions. BMC Endocr Disord. 2014;14:88.

    PubMed  PubMed Central  Google Scholar 

  43. Casal RF, Jimenez CA, Mehran RJ, Eapen GA, Ost D, Sarkiss M, et al. Infected mediastinal bronchogenic cyst successfully treated by endobronchial ultrasound-guided fine-needle aspiration. Ann Thorac Surg. 2010;90(4):52–3.

    Google Scholar 

  44. Anantham D, Phua GC, Low SY, Koh MS. Role of endobronchial ultrasound in the diagnosis of bronchogenic cysts. Diagn Ther Endosc. 2011;2011:468237.

    PubMed  PubMed Central  Google Scholar 

  45. Moonim MT, Breen R, Gill-Barman B, Santis G. Diagnosis and subclassification of thymoma by minimally invasive fine needle aspiration directed by endobronchial ultrasound: a review and discussion of four cases. Cytopathology. 2012;23(4):220–8.

    CAS  PubMed  Google Scholar 

  46. Yoshida Y, Singyoji M, Ashinuma H, Itakura M, Iizasa T, Tatsumi K. Successful diagnosis of a thymoma by endobronchial ultrasound-guided transbronchial needle aspiration: a report of two cases. Intern Med. 2015;54(21):2735–9.

    PubMed  Google Scholar 

  47. Sanz-Santos J, Cirauqui B, Sanchez E, Andreo F, Serra P, Monso E, et al. Endobronchial ultrasound-guided transbronchial needle aspiration in the diagnosis of intrathoracic lymph node metastases from extrathoracic malignancies. Clin Exp Metastasis. 2013;30(4):521–8.

    PubMed  Google Scholar 

  48. Navani N, Nankivell M, Woolhouse I, Harrison RN, Munavvar M, Oltmanns U, et al. Endobronchial ultrasound-guided transbronchial needle aspiration for the diagnosis of intrathoracic lymphadenopathy in patients with extrathoracic malignancy: a multicenter study. J Thorac Oncol. 2011;6(9):1505–9.

    PubMed  PubMed Central  Google Scholar 

  49. Tournoy KG, Govaerts E, Malfait T, Dooms C. Endobronchial ultrasound-guided transbronchial needle biopsy for M1 staging of extrathoracic malignancies. Ann Oncol. 2011;22(1):127–31.

    CAS  PubMed  Google Scholar 

  50. Grosu HB, Iliesiu M, Caraway NP, Medeiros LJ, Lei X, Jimenez CA, et al. Endobronchial ultrasound-guided transbronchial needle aspiration for the diagnosis and subtyping of lymphoma. Ann Am Thorac Soc. 2015;12(9):1336–44.

    PubMed  Google Scholar 

  51. Detterbeck FC, Lewis SZ, Diekemper R, Addrizzo-Harris D, Alberts WM. Executive Summary: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest. 2013;143(5):7–37.

    Google Scholar 

  52. Romano M, Libshitz HI. Hodgkin disease and non-Hodgkin lymphoma: plain chest radiographs and chest computed tomography of thoracic involvement in previously untreated patients. Radiol Med. 1998;95(1-2):49–53.

    CAS  PubMed  Google Scholar 

  53. Steinfort DP, Conron M, Tsui A, Pasricha SR, Renwick WE, Antippa P, et al. Endobronchial ultrasound-guided transbronchial needle aspiration for the evaluation of suspected lymphoma. J Thorac Oncol. 2010;5(6):804–9.

    PubMed  Google Scholar 

  54. Kennedy MP, Jimenez CA, Bruzzi JF, Mhatre AD, Lei X, Giles FJ, et al. Endobronchial ultrasound-guided transbronchial needle aspiration in the diagnosis of lymphoma. Thorax. 2008;63(4):360–5.

    CAS  PubMed  Google Scholar 

  55. Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics, 2012. CA Cancer J Clin. 2015;65(2):87–108.

    PubMed  Google Scholar 

  56. Barta JA, Powell CA, Wisnivesky JP. Global epidemiology of lung cancer. Ann Glob Health. 2019;85(1):8.

    PubMed  PubMed Central  Google Scholar 

  57. Aberle DR, Adams AM, Berg CD, Black WC, Clapp JD, Fagerstrom RM, et al. Reduced lung-cancer mortality with low-dose computed tomographic screening. N Engl J Med. 2011;365(5):395–409.

    PubMed  Google Scholar 

  58. Horeweg N, Scholten ET, de Jong PA, van der Aalst CM, Weenink C, Lammers JW, et al. Detection of lung cancer through low-dose CT screening (NELSON): a prespecified analysis of screening test performance and interval cancers. Lancet Oncol. 2014;15(12):1342–50.

    PubMed  Google Scholar 

  59. Silvestri GA, Gonzalez AV, Jantz MA, Margolis ML, Gould MK, Tanoue LT, et al. Methods for staging non-small cell lung cancer: diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest. 2013;143(5 Suppl):e211S–e50S.

    PubMed  Google Scholar 

  60. Goldstraw P, Chansky K, Crowley J, Rami-Porta R, Asamura H, Eberhardt WE, et al. The IASLC lung cancer staging project: proposals for revision of the TNM stage groupings in the forthcoming (eighth) edition of the TNM classification for lung cancer. J Thorac Oncol. 2016;11(1):39–51.

    PubMed  Google Scholar 

  61. Memoli JS, El-Bayoumi E, Pastis NJ, Tanner NT, Gomez M, Huggins JT, et al. Using endobronchial ultrasound features to predict lymph node metastasis in patients with lung cancer. Chest. 2011;140(6):1550–6.

    Google Scholar 

  62. Yasufuku K, Chiyo M, Koh E, Moriya Y, Iyoda A, Sekine Y, et al. Endobronchial ultrasound guided transbronchial needle aspiration for staging of lung cancer. Lung Cancer. 2005;50(3):347–54.

    PubMed  Google Scholar 

  63. Yasufuku K, Nakajima T, Motoori K, Sekine Y, Shibuya K, Hiroshima K, et al. Comparison of endobronchial ultrasound, positron emission tomography, and CT for lymph node staging of lung cancer. Chest. 2006;130(3):710–8.

    PubMed  Google Scholar 

  64. Herth FJ, Eberhardt R, Krasnik M, Ernst A. Endobronchial ultrasound-guided transbronchial needle aspiration of lymph nodes in the radiologically and positron emission tomography-normal mediastinum in patients with lung cancer. Chest. 2008;133(4):887–91.

    PubMed  Google Scholar 

  65. Hwangbo B, Kim SK, Lee HS, Lee HS, Kim MS, Lee JM, et al. Application of endobronchial ultrasound-guided transbronchial needle aspiration following integrated PET/CT in mediastinal staging of potentially operable non-small cell lung cancer. Chest. 2009;135(5):1280–7.

    PubMed  Google Scholar 

  66. Ernst A, Anantham D, Eberhardt R, Krasnik M, Herth FJ. Diagnosis of mediastinal adenopathy-real-time endobronchial ultrasound guided needle aspiration versus mediastinoscopy. J Thorac Oncol. 2008;3(6):577–82.

    PubMed  Google Scholar 

  67. Annema JT, van Meerbeeck JP, Rintoul RC, Dooms C, Deschepper E, Dekkers OM, et al. Mediastinoscopy vs endosonography for mediastinal nodal staging of lung cancer: a randomized trial. JAMA. 2010;304(20):2245–52.

    CAS  PubMed  Google Scholar 

  68. Yasufuku K, Pierre A, Darling G, de Perrot M, Waddell T, Johnston M, et al. A prospective controlled trial of endobronchial ultrasound-guided transbronchial needle aspiration compared with mediastinoscopy for mediastinal lymph node staging of lung cancer. J Thorac Cardiovasc Surg. 2011;142(6):1393–400.

    PubMed  Google Scholar 

  69. Rintoul RC, Skwarski KM, Murchison JT, Wallace WA, Walker WS, Penman ID. Endobronchial and endoscopic ultrasound-guided real-time fine-needle aspiration for mediastinal staging. Eur Respir J. 2005;25(3):416–21.

    CAS  PubMed  Google Scholar 

  70. Vilmann P, Krasnik M, Larsen SS, Jacobsen GK, Clementsen P. Transesophageal endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) and endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) biopsy: a combined approach in the evaluation of mediastinal lesions. Endoscopy. 2005;37(9):833–9.

    CAS  PubMed  Google Scholar 

  71. Herth FJ, Krasnik M, Kahn N, Eberhardt R, Ernst A. Combined endoscopic-endobronchial ultrasound-guided fine-needle aspiration of mediastinal lymph nodes through a single bronchoscope in 150 patients with suspected lung cancer. Chest. 2010;138(4):790–4.

    PubMed  Google Scholar 

  72. Hwangbo B, Lee GK, Lee HS, Lim KY, Lee SH, Kim HY, et al. Transbronchial and transesophageal fine-needle aspiration using an ultrasound bronchoscope in mediastinal staging of potentially operable lung cancer. Chest. 2010;138(4):795–802.

    PubMed  Google Scholar 

  73. Daly ME, Singh N, Ismaila N, Antonoff MB, Arenberg DA, Bradley J, et al. Management of stage III non-small-cell lung cancer: ASCO guideline. J Clin Oncol. 2021;40(12):1356–84.

    PubMed  Google Scholar 

  74. Koshy M, Fedewa SA, Malik R, Ferguson MK, Vigneswaran WT, Feldman L, et al. Improved survival associated with neoadjuvant chemoradiation in patients with clinical stage IIIA(N2) non-small-cell lung cancer. J Thorac Oncol. 2013;8(7):915–22.

    CAS  PubMed  Google Scholar 

  75. Eberhardt WE, Pöttgen C, Gauler TC, Friedel G, Veit S, Heinrich V, et al. Phase III study of surgery versus definitive concurrent chemoradiotherapy boost in patients with resectable stage IIIA(N2) and selected IIIB non-small-cell lung cancer after induction chemotherapy and concurrent chemoradiotherapy (ESPATUE). J Clin Oncol. 2015;33(35):4194–201.

    CAS  PubMed  Google Scholar 

  76. Herth FJ, Annema JT, Eberhardt R, Yasufuku K, Ernst A, Krasnik M, et al. Endobronchial ultrasound with transbronchial needle aspiration for restaging the mediastinum in lung cancer. J Clin Oncol. 2008;26(20):3346–50.

    PubMed  Google Scholar 

  77. Lindeman NI, Cagle PT, Aisner DL, Arcila ME, Beasley MB, Bernicker EH, et al. Updated molecular testing guideline for the selection of lung cancer patients for treatment with targeted tyrosine kinase inhibitors: guideline from the College of American Pathologists, the International Association for the Study of Lung Cancer, and the Association for Molecular Pathology. J Mol Diagn. 2018;20(2):129–59.

    CAS  PubMed  Google Scholar 

  78. Kalemkerian GP, Narula N, Kennedy EB. Molecular testing guideline for the selection of lung cancer patients for treatment with targeted tyrosine kinase inhibitors: American Society of Clinical Oncology Endorsement Summary of the College of American Pathologists/International Association for the Study of Lung Cancer/Association for Molecular Pathology clinical practice guideline update. J Oncol Pract. 2018;14(5):323–7.

    PubMed  Google Scholar 

  79. Martin-Deleon R, Teixido C, Lucena CM, Martinez D, Fontana A, Reyes R, et al. EBUS-TBNA cytological samples for comprehensive molecular testing in non-small cell lung cancer. Cancer. 2021;13(9):2084.

    CAS  Google Scholar 

  80. Righi L, Franzi F, Montarolo F, Gatti G, Bongiovanni M, Sessa F, et al. Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA)-from morphology to molecular testing. J Thorac Dis. 2017;9(5):395–404.

    Google Scholar 

  81. Casadio C, Guarize J, Donghi S, Di Tonno C, Fumagalli C, Vacirca D, et al. Molecular testing for targeted therapy in advanced non-small cell lung cancer: suitability of endobronchial ultrasound transbronchial needle aspiration. Am J Clin Pathol. 2015;144(4):629–34.

    CAS  PubMed  Google Scholar 

  82. Faber E, Grosu H, Sabir S, San Lucas FA, Barkoh BA, Bassett RL, et al. Adequacy of small biopsy and cytology specimens for comprehensive genomic profiling of patients with non-small-cell lung cancer to determine eligibility for immune checkpoint inhibitor and targeted therapy. J Clin Pathol. 2021;75(9):612–9.

    PubMed  Google Scholar 

  83. Varela-Lema L, Fernández-Villar A, Ruano-Ravina A. Effectiveness and safety of endobronchial ultrasound-transbronchial needle aspiration: a systematic review. Eur Respir J. 2009;33(5):1156–64.

    CAS  PubMed  Google Scholar 

  84. Hayama M, Izumo T, Matsumoto Y, Chavez C, Tsuchida T, Sasada S. Complications with endobronchial ultrasound with a guide sheath for the diagnosis of peripheral pulmonary lesions. Respiration. 2015;90(2):129–35.

    PubMed  Google Scholar 

  85. Chen A, Chenna P, Loiselle A, Massoni J, Mayse M, Misselhorn D. Radial probe endobronchial ultrasound for peripheral pulmonary lesions. A 5-year institutional experience. Ann Am Thorac Soc. 2014;11(4):578–82.

    PubMed  Google Scholar 

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Goizueta, A.A., Eapen, G.A. (2023). Endobronchial Ultrasound. In: Díaz-Jiménez, J.P., Rodríguez, A.N. (eds) Interventions in Pulmonary Medicine. Springer, Cham. https://doi.org/10.1007/978-3-031-22610-6_23

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