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The Role of 5-HT2B Receptor on Aggression and Drugs of Abuse

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5-HT2B Receptors

Part of the book series: The Receptors ((REC,volume 35))

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Abstract

Monoamines, particularly serotonin (5-hydroxytryptamine, 5-HT), have been extensively studied in the context of aggression. 5-HT is known to play a key role in the modulation of aggressive, impulsive, antisocial, and violent behavior. There are several hypotheses that intend to explain the underlying relationship between 5-HT and aggressive behavior. While normal levels of 5-HT have an inhibitory effect on brain regions involved in aggressive behavior, a reduction in 5-HT activity increases aggression. Genetic factors are involved in the relationship between 5-HT and aggressive behavior and several genetic variants that influence aggressive behavior have been identified. 5-HT effects are mediated by at least 14 receptor subtypes and grouped into seven 5-HT receptor families (5-HT1–5-HT7 receptor). In the brain, 5-HT receptors are distributed pre- and post-synaptically and it is believed that these different subtypes may exert opposing effects on aggressive behavior. Aggressive behavior is influenced by a combination of genetic and environmental factors, including substance use. A high proportion of all crimes are committed under the influence of substances of abuse including alcohol, cannabis, cocaine. In this chapter, we will focus on 5-HT2B receptor and will discuss its role in the modulation of aggressive and impulsive behaviors as well as related traits such as drug abuse.

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Authors and Affiliations

  1. Department of Psychiatry, Division of Human Genetics, Yale School of Medicine, West Haven, CT, USA

    Janitza L. Montalvo-Ortiz

  2. Department of Psychiatry and Behavioral Health, The Ohio State University Wexner Medical Center, Columbus, OH, USA

    Emil F. Coccaro

Authors
  1. Janitza L. Montalvo-Ortiz
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  2. Emil F. Coccaro
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Correspondence to Janitza L. Montalvo-Ortiz .

Editor information

Editors and Affiliations

  1. Inserm, U1270, Institut du Fer a Moulin, Paris, France

    Luc Maroteaux

  2. Pharmacology, Strasbourg Medical school, Strasbourg, France

    Laurent Monassier

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Montalvo-Ortiz, J.L., Coccaro, E.F. (2021). The Role of 5-HT2B Receptor on Aggression and Drugs of Abuse. In: Maroteaux, L., Monassier, L. (eds) 5-HT2B Receptors. The Receptors, vol 35. Springer, Cham. https://doi.org/10.1007/978-3-030-55920-5_17

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