Myofibroblast activation requires nuclear translocation of ATP citrate lyase (ACLY) that triggers chromatin remodeling and the induction of fibrosis-associated genes. ACLY inhibition prevents myofibroblast conversion and causes de-differentiation of myofibroblasts to fibroblasts, indicating a potential therapeutic approach for heart failure.
This is a preview of subscription content, log in via an institution to check access.
References
Humeres, C. et al. J. Clin. Invest. 132, e146926 (2022).
Gibb, A. A., Lazaropoulos, M. P. & Elrod, J. W. Circ. Res. 127, 427–447 (2020).
Lombardi, A. A. et al. Nat. Commun. 10, 4509 (2019).
Lazaropoulos, M. P. et al. Nat. Cardiovasc. Res. https://doi.org/10.1038/s44161-024-00502-3 (2024).
Moussaieff, A. et al. Cell Metab. 21, 392–402 (2015).
Younesi, F. S., Miller, A. E., Barker, T. H., Rossi, F. M. V. & Hinz, B. Nat. Rev. Mol. Cell Biol. https://doi.org/10.1038/s41580-024-00716-0 (2024).
Li, Y. et al. J. Mol. Cell Cardiol. 171, 117–132 (2022).
Tallquist, M. D. Annu. Rev. Physiol. 82, 63–78 (2020).
McLellan, M. A. et al. Circulation 142, 1448–1463 (2020).
Fu, X. et al. J. Clin. Invest. 128, 2127–2143 (2018).
Acknowledgements
N.G.F.’s laboratory is supported by National Institutes of Health (NIH) grants R01 HL76246, R01 HL85440 and R01 HL149407, and by US Department of Defense grant PR211352.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing interests.
Rights and permissions
About this article
Cite this article
Frangogiannis, N.G. Targeting metabolically activated fibroblasts in the failing heart. Nat Cardiovasc Res 3, 782–784 (2024). https://doi.org/10.1038/s44161-024-00500-5
Published:
Issue Date:
DOI: https://doi.org/10.1038/s44161-024-00500-5
- Springer Nature Limited