A machine learning-derived gene signature that integrates germline HLA characteristics with a distinct spatial community of CD8+ T cells and tumor-associated macrophages showing immunogenic interactions is predictive of the response to immunotherapy in patients with advanced kidney cancer.
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References
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This is a summary of: Kinget, L. et al. A spatial architecture-embedding HLA signature to predict clinical response to immunotherapy in renal cell carcinoma. Nat. Med. https://doi.org/10.1038/s41591-024-02978-9 (2024).
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Heritable and spatial immunogenic traits co-predict the efficacy of immunotherapy in kidney cancer. Nat Med 30, 1537–1538 (2024). https://doi.org/10.1038/s41591-024-03020-8
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DOI: https://doi.org/10.1038/s41591-024-03020-8
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