Extended Data Fig. 3: Associations between all CSF biomarkers and tau-PET in the Braak I-IV ROI.
From: CSF MTBR-tau243 is a specific biomarker of tau tangle pathology in Alzheimer’s disease
Associations between CSF biomarkers and tau-PET in the Braak I-IV ROI (SUVR) in BioFINDER-2 (A) and Knight ADRC (B) participants. Linear regression models, adjusting for age and sex, were used to obtain standardized β and p-values shown in the plots. In the BioFINDER-2 cohort, orange dots represent MCI+ participants whereas in the Kinght-ADRC cohort, represent very mild AD. *, p < 0.050; **, p < 0.010; ***, p < 0.001. Abbreviations: AD + , Alzheimer’s disease dementia amyloid positive; CSF, cerebrospinal fluid; CU-, cognitively unimpaired amyloid negative; CU + , cognitively unimpaired amyloid positive; MCI + , mild cognitive impairment amyloid positive; MTBR, microtubule binding region; non-AD, non-Alzheimer’s disease dementia; PET, positron emission tomography, SUVR, standardized uptake value ratio.