Extended Data Fig. 5: Longitudinal CSF biomarkers trajectories by baseline “A” and “T” status.
From: CSF MTBR-tau243 is a specific biomarker of tau tangle pathology in Alzheimer’s disease
Individual (shaded lines) and group (bold lines) CSF biomarker levels trajectories over time based on their A/T baseline status. Statistical differences to the reference group (A-T-) are shown with asterisks with the appropriate color. Longitudinal CSF data was only available in BioFINDER-2. Amyloid-positive participants were selected based on a CSF Aβ42/40 previously validated cutoff (CSF Aβ42/40 < 0.08). Tau positivity was assessed based on tau-PET SUVR in the meta-ROI (Braak I-IV SUVR > 1.32). *, p < 0.050; **, p < 0.010; ***, p < 0.001. Abbreviations: A-T-, amyloid and tau negative; A + T-, amyloid positive and tau negative; A + T + , amyloid positive, tau positive; CSF, cerebrospinal fluid; MTBR, microtubule binding region; PET, positron emission tomography.