Cellular organelles form an interconnected and dynamic network that orchestrates cellular functions. Using a multispectral imaging and computational analysis approach (‘OrgaPlexing’), a study now identifies multi-organelle units as crucial regulators of metabolic reprogramming in primary macrophages upon inflammatory stimuli.
References
Bernhard, W. & Rouiller, C. J. Biophys. Biochem. Cytol. 2, 73–78 (1956).
Copeland, D. E. & Dalton, A. J. J. Biophys. Biochem. Cytol. 5, 393–396 (1959).
Scorrano, L. et al. Nat. Commun. 10, 1287 (2019).
Valm, A. M. et al. Nature 546, 162–167 (2017).
Zimmermann, J. A. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-024-01457-0 (2024).
Hsieh, W.-Y. et al. Cell Metab. 32, 128–143.e5 (2020).
Jha, A. K. et al. Immunity 42, 419–430 (2015).
Castoldi, A. et al. Nat. Commun. 11, 4107 (2020).
Ngo, J. et al. EMBO J. 42, e111901 (2023).
Freyre, C. A. C. et al. Mol. Cell 76, 811–825.e14 (2019).
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Pilic, J., Kleele, T. An organelle tango controls lipid metabolism. Nat Cell Biol (2024). https://doi.org/10.1038/s41556-024-01441-8
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DOI: https://doi.org/10.1038/s41556-024-01441-8
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