Extended Data Figure 8: Functional in vitro modelling of δ-catenin missense variants in embryonic rat hippocampal neurons.

a, Representation of spines along the dendrite in control and overexpression GFP vectors (empty or fused with wild-type or variant allele containing CTNND2 (G34S, R713C, A482T (control)). Cell counts for each construct were as follows: GFP (N = 32), GFP–WT (N = 27), GFP–G34S (N = 29), GFP–R713C (N = 26) and GFP–A482T (N = 29). b, Quantification of dendritic spine numbers and statistical comparisons by Tukey’s honestly significant test following ANOVA. Both P < 0.05 than GFP and significantly different from wild type, respectively.