Skip to main content

Advertisement

SpringerLink
Log in

Cognitive impairment and dementia in young onset Parkinson’s disease

  • Original Communication
  • Published:
Journal of Neurology Aims and scope Submit manuscript

Abstract

Background and objective

Patients with young-onset Parkinson’s disease (YOPD) have a slower progression. Our aim was to analyze the change in cognitive function in YOPD compared to patients with a later onset and controls.

Patients and methods

Patients with Parkinson’s disease (PD) and controls from the COPPADIS cohort were included. Cognitive function was assessed with the Parkinson’s Disease Cognitive Rating Scale (PD-CRS) at baseline (V0), 2-year ± 1 month (V2y), and 4-year ± 3 months follow-up (V4y). Regarding age from symptoms onset, patients were classified as YOPD (< 50 years) or non-YOPD (≥ 50). A score in the PD-CRS < 81 was defined as cognitive impairment (CI): ≤ 64 dementia; 65–80 mild cognitive impairment (MCI).

Results

One-hundred and twenty-four YOPD (50.7 ± 7.9 years; 66.1% males), 234 non-YOPD (67.8 ± 7.8 years; 59.3% males) patients, and 205 controls (61 ± 8.3 years; 49.5% males) were included. The score on the PD-CRS and its subscore domains was higher at all visits in YOPD compared to non-YOPD patients and to controls (p < 0.0001 in all analysis), but no differences were detected between YOPD patients and controls. Only non-YOPD patients had significant impairment in their cognitive function from V0 to V4y (p < 0.0001). At V4y, the frequency of dementia and MCI was 5% and 10% in YOPD compared to 25.2% and 22.3% in non-YOPD patients (p < 0.0001). A lower score on the Parkinson’s Disease Sleep Scale at baseline was a predictor of CI at V4y in YOPD patients (Adjusted R2 = 0.61; OR = 0.965; p = 0.029).

Conclusion

Cognitive dysfunction progressed more slowly in YOPD than in non-YOPD patients.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

Abbreviations

ADL:

Activities for daily living

ADLS:

Schwab and England Activities of Daily Living Scale

BDI-II:

Beck Depression Inventory-II

FOGQ:

Freezing of Gait Questionnaire

LEDD:

Levodopa equivalent daily dose

NMSS:

Non-Motor Symptoms Scale

NPI:

Neuropsychiatric Inventory

PD:

Parkinson’s disease

PD-CRS:

Parkinson’s Disease Cognitive Rating Scale

PDQ-39:

The 39-item Parkinson’s disease Questionnaire Summary Index

PDD:

Parkinson’s disease dementia

PD-MCI:

Parkinson’s disease with mild cognitive impairment

PD-NC:

Parkinson’s disease with normal cognition. PDSS: Parkinson’s Disease Sleep Scale

QUIP-RS:

Questionnaire for Impulsive-Compulsive Disorders in Parkinson’s Disease-Rating Scale

UPDRS:

Unified Parkinson’s Disease-Rating Scale

VAS:

Visual Analogue Scale

YOPD:

Young-onset PD

References

  1. Greenland JC, Williams-Gray CH, Barker RA (2019) The clinical heterogeneity of Parkinson’s disease and its therapeutic implications. Eur J Neurosci 49:328–338

    Article  PubMed  Google Scholar 

  2. Titova N, Padmakumar C, Lewis SJG, Chaudhuri KR (2017) Parkinson’s: a syndrome rather than a disease? J Neural Transm (Vienna) 124:907–914

    Article  CAS  PubMed  Google Scholar 

  3. Hughes AJ, Daniel SE, Kilford L, Lees AJ (1992) Accuracy of clinical diagnosis of idiopathic Parkinson’s disease: a clinico-pathological study of 100 cases. J Neurol Neurosurg Psychiatry 55:181–184

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Postuma RB, Berg D, Stern M et al (2015) MDS clinical diagnostic criteria for Parkinson’s disease. Mov Disord 30:1591–1601

    Article  PubMed  Google Scholar 

  5. Post B, van den Heuvel L, van Prooije T, van Ruissen X, van de Warrenburg B, Nonnekes J (2020) Young onset Parkinson’s disease: a modern and tailored approach. J Parkinsons Dis 10(s1):S29-36

    Article  PubMed  PubMed Central  Google Scholar 

  6. Morales-Briceno H, Mohammad SS, Post B et al (2020) Clinical and neuroimaging phenotypes of genetic parkinsonism from infancy to adolescence. Brain 143:751–770

    Article  PubMed  Google Scholar 

  7. Mehanna R, Jankovic J (2019) Young-onset Parkinson’s disease: Its unique features and their impact on quality of life. Parkinsonism Relat Disord 65:39–48

    Article  PubMed  Google Scholar 

  8. Butterfield PG, Valanis BG, Spencer PS, Lindeman CA, Nutt JG (1993) Environmental antecedents of young-onset Parkinson’s disease. Neurology 43:1150–1158

    Article  CAS  PubMed  Google Scholar 

  9. Pagano G, Ferrara N, Brooks DJ, Pavese N (2016) Age at onset and Parkinson disease phenotype. Neurology 86:1400–1407

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Schrag A, Hovris A, Morley D, Quinn N, Jahanshahim M (2003) Young- versus older-onset Parkinson’s disease: impact of disease and psychosocial consequences. Mov Disord 18:1250–1256

    Article  PubMed  Google Scholar 

  11. Klepac N, Habek M, Adamec I et al (2013) An update on the management of young-onset Parkinson’s disease. Degener Neurol Neuromuscul Dis 2:53–62

    PubMed  PubMed Central  Google Scholar 

  12. Quinn N, Critchley P, Marsden CD (1987) Young onset Parkinson’s disease. Mov Disord 2:73–91

    Article  CAS  PubMed  Google Scholar 

  13. Holden HM, Schweer CN, Tröster AI (2021) Impact of mild cognitive impairment on quality of life in young and typical onset Parkinson’s disease. Mov Disord Clin Pract 9:69–75

    Article  PubMed  PubMed Central  Google Scholar 

  14. Willis AW, Schootman M, Kung N, Racette BA (2013) Epidemiology and neuropsychiatric manifestations of young onset Parkinson’s disease in the United States. Parkinsonism Relat Disord 19:202–206

    Article  CAS  PubMed  Google Scholar 

  15. Santos García D, Jesús S, Aguilar M et al (2019) COPPADIS Study Group. COPPADIS-2015 (COhort of Patients with PArkinson’s DIsease in Spain, 2015): an ongoing global Parkinson’s disease project about disease progression with more than 1000 subjects included. Results from the baseline evaluation. Eur J Neurol 26:1399–1407

    Article  PubMed  Google Scholar 

  16. Santos-García D, Mir P, Cubo E et al (2016) COPPADIS Study Group. COPPADIS-2015 (COhort of Patients with PArkinson’s DIsease in Spain, 2015), a global--clinical evaluations, serum biomarkers, genetic studies and neuroimaging--prospective, multi-center, non-interventional, long-term study on Parkinson’s disease progression. BMC Neurol 16:26

    Article  PubMed  PubMed Central  Google Scholar 

  17. Zhou Z, Zhou X, Xiang Y et al (2022) Subtyping of early-onset Parkinson’s disease using cluster analysis: a large cohort study. Front Aging Neurosci 14:1040293

    Article  PubMed  PubMed Central  Google Scholar 

  18. Zhao Y, Qin L, Pan H et al (2020) The role of genetics in Parkinson’s disease: a large cohort study in Chinese mainland population. Brain 143:2220–2234

    Article  PubMed  Google Scholar 

  19. Poewe W, Seppi K, Tanner CM, Halliday GM, Brundin P, Volkmann J, Schrag AE, Lang AE (2017) Parkinson disease. Nat Rev Dis Primers 23(3):17013

    Article  Google Scholar 

  20. Pagonabarraga J, Kulisevsky J, Llebaria G, García-Sánchez C, Pascual-Sedano B, Gironell A (2008) Parkinson’s disease-cognitive rating scale: a new cognitive scale specific for Parkinson’s disease. Mov Disord 23:998–1005

    Article  PubMed  Google Scholar 

  21. Fernandez de Bobadilla R, Pagonabarraga J, Martinez-Horta S, Pascual-Sedano B, Campolongo A, Kulisevsky J (2013) Parkinson’s disease-cognitive rating scale: psychometrics for mild cognitive impairment. Mov Disord 28:1376–1383

    Article  PubMed  Google Scholar 

  22. Schade S, Mollenhauer B, Trenkwalder C (2020) Levodopa equivalent dose conversion factors: an updated proposal including Opicapone and Safinamide. Mov Disord Clin Pract 7:343–345

    Article  PubMed  PubMed Central  Google Scholar 

  23. Selikhova M, Williams DR, Kempster PA, Holton JL, Revesz T, Lees AJ (2009) A clinico-pathological study of subtypes in Parkinson’s disease. Brain 132(Pt 11):2947–2957

    Article  CAS  PubMed  Google Scholar 

  24. Ferguson LW, Rajput AH, Rajput A (2016) Early-onset vs. late-onset Parkinson’s disease: a clinical-pathological study. Can J Neurol Sci 43:113–119

    Article  PubMed  Google Scholar 

  25. Schrag A, Schott JM (2006) Epidemiological, clinical, and genetic characteristics of early-onset parkinsonism. Lancet Neurol 5:355–363

    Article  CAS  PubMed  Google Scholar 

  26. Wickremaratchi MM, Ben-Shlomo Y, Morris HR (2009) The effect of onset age on the clinical features of Parkinson’s disease. Eur J Neurol 16:450–456

    Article  CAS  PubMed  Google Scholar 

  27. Lawson RA, Yarnall AJ, Duncan GW et al (2014) Severity of mild cognitive impairment in early Parkinson’s disease contributes to poorer quality of life. Parkinsonism Relat Disord 20:1071–1075

    Article  PubMed  PubMed Central  Google Scholar 

  28. Tang H, Huang J, Nie K et al (2016) Cognitive profile of Parkinson’s disease patients: a comparative study between early-onset and late-onset Parkinson’s disease. Int J Neurosci 126:227–234

    Article  PubMed  Google Scholar 

  29. Mayeux R, Denaro J, Hemenegildo N et al (1992) A population-based investigation of Parkinson’s disease with and without dementia. Relationship to age and gender. Arch Neurol 49:492–497

    Article  CAS  PubMed  Google Scholar 

  30. Anang JB, Gagnon JF, Bertrand JA et al (2014) Predictors of dementia in Parkinson disease: a prospective cohort study. Neurology 83:1253–1260

    Article  PubMed  PubMed Central  Google Scholar 

  31. Phongpreecha T, Cholerton B, Mata IF et al (2020) Multivariate prediction of dementia in Parkinson’s disease. NPJ Parkinsons Dis 6:20

    Article  PubMed  PubMed Central  Google Scholar 

  32. Bohnen NI, Hu MTM (2019) Sleep disturbance as potential risk and progression factor for Parkinson’s disease. J Parkinsons Dis 9:603–614

    Article  PubMed  PubMed Central  Google Scholar 

  33. Matsumoto S, Tsunematsu T (2021) Association between Sleep, Alzheimer’s, and Parkinson’s disease. Biology (Basel) 10:1127

    CAS  PubMed  Google Scholar 

  34. Minakawa EN (2022) Bidirectional relationship between sleep disturbances and Parkinson’s disease. Front Neurol 13:927994

    Article  PubMed  PubMed Central  Google Scholar 

  35. Leocadi M, Canu E, Donzuso G et al (2022) Longitudinal clinical, cognitive, and neuroanatomical changes over 5 years in GBA-positive Parkinson’s disease patients. J Neurol 269:1485–1500

    Article  PubMed  Google Scholar 

  36. Santos García D, de Deus Fonticoba T, Suárez Castro E et al (2019) Coppadis Study Group. Non-motor symptoms burden, mood, and gait problems are the most significant factors contributing to a poor quality of life in non-demented Parkinson’s disease patients: results from the COPPADIS Study Cohort. Parkinsonism Relat Disord 66:151–157

    Article  PubMed  Google Scholar 

  37. Spica V, Pekmezović T, Svetel M, Kostić VS (2013) Prevalence of non-motor symptoms in young-onset versus late-onset Parkinson’s disease. J Neurol 260:131–137

    Article  PubMed  Google Scholar 

  38. Kim R, Shin JH, Park S, Kim HJ, Jeon B (2020) Longitudinal evolution of non-motor symptoms according to age at onset in early Parkinson’s disease. J Neurol Sci 418:117157

    Article  CAS  PubMed  Google Scholar 

  39. Vela L, Martínez Castrillo JC, García Ruiz P et al (2016) The high prevalence of impulse control behaviors in patients with early-onset Parkinson’s disease: a cross-sectional multi-center study. J Neurol Sci 368:150–154

    Article  CAS  PubMed  Google Scholar 

  40. Kelly MJ, Lawton MA, Baig F et al (2019) Predictors of motor complications in early Parkinson’s disease: a prospective cohort study. Mov Disord 34:1174–1183

    Article  PubMed  PubMed Central  Google Scholar 

  41. Te Groen M, Bloem BR, Wu SS, Post B (2021) Parkinson’s Foundation Quality Improvement Initiative investigators. Better quality of life and less caregiver strain in young-onset Parkinson’s disease: a multicentre retrospective cohort study. J Neurol 268:1102–1109

    Article  Google Scholar 

  42. Knipe MD, Wickremaratchi MM, Wyatt-Haines E, Morris HR, Ben-Shlomo Y (2011) Quality of life in young- compared with late-onset Parkinson’s disease. Mov Disord 26:2011–2018

    Article  PubMed  Google Scholar 

  43. Schrag A, Jahanshahi M, Quinn N (2000) How does Parkinson’s disease affect quality of life? A comparison with quality of life in the general population. Mov Disord 15:1112–1118

    Article  CAS  PubMed  Google Scholar 

  44. Lawton M, Ben-Shlomo Y, May MT et al (2018) Developing and validating Parkinson’s disease subtypes and their motor and cognitive progression. J Neurol Neurosurg Psychiatry 89:1279–1287

    Article  PubMed  Google Scholar 

  45. Fereshtehnejad SM, Romenets SR, Anang JB, Latreille V, Gagnon JF, Postuma RB (2015) New clinical subtypes of Parkinson disease and their longitudinal progression: a prospective cohort comparison with other phenotypes. JAMA Neurol 72:863–873

    Article  PubMed  Google Scholar 

  46. Dubois B, Burn D, Goetz C et al (2007) Diagnostic procedures for Parkinson’s disease dementia: recommendations from the movement disorder society task force. Mov Disord 22:2314–2324

    Article  PubMed  Google Scholar 

Download references

Acknowledgements

The authors would like to thank all patients and their caregivers who collaborated in this study. Many thanks also to Fundación Española de Ayuda a la Investigación en Enfermedades Neurodegenerativas y/o de Origen Genético (https://fundaciondegen.org/), Alpha Bioresearch (www.alphabioresearch.com), Instituto de Salud Carlos III and other institutions for helping us. COPPADIS Study Group: Adarmes AD, Almeria M, Alonso Losada MG, Alonso Cánovas A, Alonso Frech F, Alonso Redondo R, Álvarez I, Álvarez Sauco M, Aneiros Díaz A, Arnáiz S, Arribas S, Ascunce Vidondo A, Aguilar M, Ávila MA, Bernardo Lambrich N, Bejr-Kasem H, Blázquez Estrada M, Botí M, Borrue C, Buongiorno MT, Cabello González C, Cabo López I, Caballol N, Cámara Lorenzo A, Canfield Medina H, Carabajal Pendón E, Carrillo F, Carrillo Padilla FJ, Casas E, Catalán MJ, Clavero P, Cortina Fernández A, Cosgaya M, Cots Foraster A, Crespo Cuevas A, Cubo E, de Deus Fonticoba T, de Fábregues-Boixar O, Díez-Fairen M, Dotor García-Soto J, Erro E, Escalante S, Estelrich Peyret E, Fernández Guillán N, Gámez P, Gallego M, García Caldentey J, García Campos C, García Díez C, García Moreno JM, Gastón I, Gómez Garre MP, Gómez Mayordomo V, González Aloy J, González-Aramburu I, González Ardura J, González García B, González Palmás MJ, González Toledo GR, Golpe Díaz A, Grau Solá M, Guardia G, Hernández Vara J, Horta-Barba A, Idoate Calderón D, Infante J, Jesús S, Kulisevsky J, Kurtis M, Labandeira C, Labrador MA, Lacruz F, Lage Castro M, Lastres Gómez S, Legarda I, López Ariztegui N, López Díaz LM, López Domínguez D, López Manzanares L, López Seoane B, Lucas del Pozo S, Macías Y, Mata M, Martí Andres G, Martí MJ, Martínez Castrillo JC, Martinez-Martin P, McAfee D, Meitín MT, Mendoza Plasencia Z, Menéndez González M, Méndez del Barrio C, Mir P, Miranda Santiago J, Morales Casado MI, Moreno Diéguez A, Muro García I, Nogueira V, Novo Amado A, Novo Ponte S, Ordás C, Pagonabarraga J, Pareés I, Pascual-Sedano B, Pastor P, Pérez Fuertes A, Pérez Noguera R, Planas-Ballvé A, Planellas L, Prats MA, Prieto Jurczynska C, Puente V, Pueyo Morlans M, Puig Daví A, Redondo Rafales N, Rodríguez Méndez L, Rodríguez Pérez AB, Roldán F, Ruíz De Arcos M, Ruíz Martínez J, Sánchez Alonso P, Sánchez-Carpintero M, Sánchez Díez G, Sánchez Rodríguez A, Santacruz P, Santos García D, Segundo Rodríguez JC, Seijo M, Sierra Peña M, Solano Vila B, Suárez Castro E, Tartari JP, Valero C, Vargas L, Vela L, Villanueva C, Vives B.

Name (Last Name, First Name)

Location

Role

Contribution

Astrid Adarmes, Daniela

Hospital Universitario Virgen del Rocío, Sevilla, Spain

Site investigator

Evaluation of participants and/or data management

Almeria, Marta

Hospital Universitari Mutua de Terrassa, Terrassa, Barcelona, Spain

Site investigator

Neuropsychologist; evaluation of participants

Alonso Losada, Maria Gema

Hospital Álvaro Cunqueiro, Complejo Hospitalario Universitario de Vigo (CHUVI), Vigo, Spain

Site investigator / PI

Coordination at the center

Evaluation of participants and/or data management

Alonso Cánovas, Araceli

Hospital Universitario Ramón y Cajal, Madrid, Spain

Site investigator

Evaluation of participants and/or data management

Alonso Frech, Fernando

Hospital Universitario Clínico San Carlos, Madrid, Spain

Site investigator

Evaluation of participants and/or data management

Alonso Redondo, Ruben

Hospital Universitario Lucus Augusti (HULA), Lugo, Spain

Site investigator / PI

Coordination at the center

Evaluation of participants and/or data management

Aneiros Díaz, Ángel

Complejo Hospitalario Universitario de Ferrol (CHUF), Ferrol, A Coruña, Spain

Site investigator / PI

Coordination at the center

Evaluation of participants and/or data management

Álvarez, Ignacio

Hospital Universitari Mutua de Terrassa, Terrassa, Barcelona, Spain

Site investigator

Evaluation of participants and/or data management

Álvarez Sauco, María

Hospital General Universitario de Elche, Elche, Spain

Site investigator / PI

Coordination at the center

Evaluation of participants and/or data management

Arnáiz, Sandra

Complejo Asistencial Universitario de Burgos, Burgos, Spain

Site investigator

Evaluation of participants and/or data management

Arribas, Sonia

Hospital Universitari Mutua de Terrassa, Terrassa, Barcelona, Spain

Site investigator

Neuropsychologist; evaluation of participants

Ascunce Vidondo, Arancha

Complejo Hospitalario de Navarra, Pamplona, Spain

Site investigator

Evaluation of participants and/or data management

Aguilar, Miquel

Hospital Universitari Mutua de Terrassa, Terrassa, Barcelona, Spain

Site investigator

Evaluation of participants and/or data management

Ávila Rivera, Maria Asunción

Consorci Sanitari Integral, Hospital General de L´Hospitalet, L´Hospitalet de Llobregat, Barcelona, Spain

Site investigator / PI

Coordination at the center

Evaluation of participants and/or data management

Bernardo Lambrich, Noemí

Hospital de Tortosa Verge de la Cinta (HTVC), Tortosa, Tarragona, Spain

Site investigator

Evaluation of participants and/or data management

Bejr-Kasem, Helena

Hospital de Sant Pau, Barcelona, Spain

Site investigator

Evaluation of participants and/or data management

Blázquez Estrada, Marta

Hospital Universitario Central de Asturias, Oviedo, Spain

Site investigator

Evaluation of participants and/or data management

Botí González, Maria Ángeles

Hospital Universitari Mutua de Terrassa, Terrassa, Barcelona, Spain

Site investigator

Neuropsychologist; evaluation of participants

Borrué, Carmen

Hospital Infanta Sofía, Madrid, Spain

Site investigator / PI

Coordination at the center

Evaluation of participants and/or data management

Buongiorno, Maria Teresa

Hospital Universitari Mutua de Terrassa, Terrassa, Barcelona, Spain

Site investigator

Nurse study coordinator

Cabello González, Carolina

Complejo Hospitalario de Navarra, Pamplona, Spain

Site investigator

Scheduling of evaluations

Cabo López, Iria

Complejo Hospitalario Universitario de Pontevedra (CHOP), Pontevedra, Spain

Site investigator / PI

Coordination at the center

Evaluation of participants and/or data management

Caballol, Nuria

Consorci Sanitari Integral, Hospital Moisés Broggi, Sant Joan Despí, Barcelona, Spain

Site investigator / PI

Coordination at the center

Evaluation of participants and/or data management

Cámara Lorenzo, Ana

Hospital Clínic de Barcelona, Barcelona, Spain

Site investigator

Nurse study coordinator

Canfield Medina, Héctor

Complejo Hospitalario Universitario de Ferrol (CHUF), Ferrol, A Coruña, Spain

Site investigator

Evaluation of participants and/or data management

Carabajal Pendón, Estefanía

Hospital La Princesa, Madrid, Spain

Site investigator (from MAR/23)

Evaluation of participants and/or data management

Carrillo, Fátima

Hospital Universitario Virgen del Rocío, Sevilla, Spain

Site investigator

Evaluation of participants and/or data management

Carrillo Padilla, Francisco José

Hospital Universitario de Canarias, San Cristóbal de la Laguna, Santa Cruz de Tenerife, Spain

Site investigator / PI

Coordination at the center

Evaluation of participants and/or data management

Casas, Elena

Complejo Asistencial Universitario de Burgos, Burgos, Spain

Site investigator

Evaluation of participants and/or data management

Catalán, Maria José

Hospital Universitario Clínico San Carlos, Madrid, Spain

Site investigator / PI

Coordination at the center

Evaluation of participants and/or data management

Clavero, Pedro

Complejo Hospitalario de Navarra, Pamplona, Spain

Site investigator

Evaluation of participants and/or data management

Cortina Fernández, A

Complejo Hospitalario Universitario de Ferrol (CHUF), Ferrol, A Coruña, Spain

Site investigator

Coordination of blood extractions

Cosgaya, Marina

Hospital Clínic de Barcelona, Barcelona, Spain

Site investigator

Evaluation of participants and/or data management

Cots Foraster, Anna

Institut d'Assistència Sanitària (IAS)—Instituí Cátala de la Salud. Girona, Spain

Site investigator

Evaluation of participants and/or data management

Crespo Cuevas, Ane

Hospital del Mar, Barcelona, Spain

Site investigator

Evaluation of participants and/or data management

Cubo, Esther

Complejo Asistencial Universitario de Burgos, Burgos, Spain

Site investigator / PI

Coordination at the center

Evaluation of participants and/or data management

De Deus Fonticoba, Teresa

Complejo Hospitalario Universitario de Ferrol (CHUF), Ferrol, A Coruña, Spain

Site investigator

Nurse study coordinator

Evaluation of participants and/or data management

De Fábregues-Boixar, Oriol

Hospital Universitario Vall d´Hebron, Barcelona, Spain

Site investigator / PI

Coordination at the center

Evaluation of participants and/or data management

Díez Fairen, M

Hospital Universitari Mutua de Terrassa, Terrassa, Barcelona, Spain

Site investigator

Evaluation of participants and/or data management

Dotor García-Soto, Julio

Hospital Universitario Virgen Macarena, Sevilla, Spain

Site investigator / PI

Evaluation of participants and/or data management

Erro, Elena

Complejo Hospitalario de Navarra, Pamplona, Spain

Site investigator

Evaluation of participants and/or data management

Escalante, Sonia

Hospital de Tortosa Verge de la Cinta (HTVC), Tortosa, Tarragona, Spain

Site investigator / PI

Coordination at the center

Evaluation of participants and/or data management

Estelrich Peyret, Elena

Institut d'Assistència Sanitària (IAS)—Instituí Cátala de la Salud. Girona, Spain

Site investigator

Evaluation of participants and/or data management

Fernández Guillán, Noelia

Complejo Hospitalario Universitario de Ferrol (CHUF), Ferrol, A Coruña, Spain

Site investigator

Neuroimaging studies

Gámez, Pedro

Complejo Asistencial Universitario de Burgos, Burgos, Spain

Site investigator

Evaluation of participants and/or data management

Gallego, Mercedes

Hospital La Princesa, Madrid, Spain

Site investigator

Evaluation of participants and/or data management

García Caldentey, Juan

Centro Neurológico Oms 42, Palma de Mallorca, Spain

Site investigator / PI

Coordination at the center

Evaluation of participants and/or data management

García Campos, Cristina

Hospital Universitario Virgen Macarena, Sevilla, Spain

Site investigator

Evaluation of participants and/or data management

García Díez, Cristina

Complejo Hospitalario Universitario de Pontevedra (CHOP), Pontevedra, Spain

Site investigator (from MAY/22)

neuropsychologist; evaluation of participants

García Moreno, Jose Manuel

Hospital Universitario Virgen Macarena, Sevilla, Spain

Site investigator / PI (until MAR/21)

Coordination at the center

Evaluation of participants and/or data management

Gastón, Itziar

Complejo Hospitalario de Navarra, Pamplona, Spain

Site investigator / PI

Coordination at the center

Evaluation of participants and/or data management

Gómez Garre, María del Pilar

Hospital Universitario Virgen del Rocío, Sevilla, Spain

Site investigator

Genetic studies coordination

Gómez Mayordomo, Víctor

Hospital Clínico San Carlos, Madrid, Spain

Site investigator*

Evaluation of participants and/or data management

González Aloy, Javier

Institut d'Assistència Sanitària (IAS)—Instituí Cátala de la Salud. Girona, Spain

Site investigator

Evaluation of participants and/or data management

González Aramburu, Isabel

Hospital Universitario Marqués de Valdecilla, Santander, Spain

Site investigator

Evaluation of participants and/or data management

González Ardura, Jessica

Hospital Universitario Lucus Augusti (HULA), Lugo, Spain

Site investigator / PI (until FEB/21)

Evaluation of participants and/or data management

González García, Beatriz

Hospital La Princesa, Madrid, Spain

Site investigator

Nurse study coordinator

González Palmás, Maria Josefa

Complejo Hospitalario Universitario de Pontevedra (CHOP), Pontevedra, Spain

Site investigator

Evaluation of participants and/or data management

González Toledo, Gabriel Ricardo

Hospital Universitario de Canarias, San Cristóbal de la Laguna, Santa Cruz de Tenerife, Spain

Site investigator

Evaluation of participants and/or data management

Golpe Díaz, Ana

Complejo Hospitalario Universitario de Ferrol (CHUF), Ferrol, A Coruña, Spain

Site investigator

Laboratory analysis coordination

Grau Solá, Mireia

Consorci Sanitari Integral, Hospital Moisés Broggi, Sant Joan Despí, Barcelona, Spain

Site investigator

Evaluation of participants and/or data management

Guardia, Gemma

Hospital Universitari Mutua de Terrassa, Terrassa, Barcelona, Spain

Site investigator

Evaluation of participants and/or data management

Hernández Vara, Jorge

Hospital Universitario Vall d´Hebron, Barcelona, Spain

Site investigator / PI

Coordination at the center

Evaluation of participants and/or data management

Horta Barba, Andrea

Hospital de Sant Pau, Barcelona, Spain

Site investigator

Neuropsychologist; evaluation of participants

Idoate Calderón, Daniel

Complejo Hospitalario Universitario de Pontevedra (CHOP), Pontevedra, Spain

Site investigaor (until MAY/22)

neuropsychologist; evaluation of participants

Infante, Jon

Hospital Universitario Marqués de Valdecilla, Santander, Spain

Site investigator / PI

Coordination at the center

Evaluation of participants and/or data management

Jesús, Silvia

Hospital Universitario Virgen del Rocío, Sevilla, Spain

Site investigator

Evaluation of participants and/or data management

Kulisevsky, Jaime

Hospital de Sant Pau, Barcelona, Spain

Site investigator / PI

Coordination at the center

Evaluation of participants and/or data management

Kurtis, Mónica

Hospital Ruber Internacional, Madrid, Spain

Site investigator / PI

Coordination at the center

Evaluation of participants and/or data management

Labandeira, Carmen

Hospital Álvaro Cunqueiro, Complejo Hospitalario Universitario de Vigo (CHUVI), Vigo, Spain

Site investigator

Evaluation of participants and/or data management

Labrador Espinosa, Miguel Ángel

Hospital Universitario Virgen del Rocío, Sevilla, Spain

Site investigator

Neuroimaging data analysis

Lacruz, Francisco

Complejo Hospitalario de Navarra, Pamplona, Spain

Site investigator

Evaluation of participants and/or data management

Lage Castro, Melva

Complejo Hospitalario Universitario de Pontevedra (CHOP), Pontevedra, Spain

Site investigator

Evaluation of participants and/or data management

Lastres Gómez, Sonia

Complejo Hospitalario Universitario de Pontevedra (CHOP), Pontevedra, Spain

Site investigator

Neuropsychologist; evaluation of participants

Legarda, Inés

Hospital Universitario Son Espases, Palma de Mallorca, Spain

Site investigator / PI

Coordination at the center

Evaluation of participants and/or data management

López Ariztegui, Nuria

Complejo Hospitalario de Toledo, Toledo, Spain

Site investigator / PI

Evaluation of participants and/or data management

López Díaz, Luis Manuel

Hospital Da Costa de Burela, Lugo, Spain

Site investigator (until DEC/16)

Evaluation of participants and/or data management

López Domínguez, Daniel

Institut d'Assistència Sanitària (IAS)—Instituí Cátala de la Salud. Girona, Spain

Site investigator

Evaluation of participants and/or data management

López Manzanares, Lydia

Hospital La Princesa, Madrid, Spain

Site investigator / PI

Coordination at the center

Evaluation of participants and/or data management

López Seoane, Balbino

Complejo Hospitalario Universitario de Ferrol (CHUF), Ferrol, A Coruña, Spain

Site investigator

Neuroimaging studies

Lucas del Pozo, Sara

Hospital Universitario Vall d´Hebron, Barcelona, Spain

Site investigator

Evaluation of participants and/or data management

Macías, Yolanda

Fundación Hospital de Alcorcón, Madrid, Spain

Site investigator

Evaluation of participants and/or data management

Mata, Marina

Hospital Infanta Sofía, Madrid, Spain

Site investigator

Evaluation of participants and/or data management

Martí Andres, Gloria

Hospital Universitario Vall d´Hebron, Barcelona, Spain

Site investigator

Evaluation of participants and/or data management

Martí, Maria José

Hospital Clínic de Barcelona, Barcelona, Spain

Site investigator / PI

Coordination at the center

Evaluation of participants and/or data management

Martínez Castrillo, Juan Carlos

Hospital Universitario Ramón y Cajal, Madrid, Spain

Site investigator /PI

Coordination at the center

Evaluation of participants and/or data management

Martinez-Martin, Pablo

CIBERNED, Instituto de Salud Carlos III, Madrid, Spain

Collaborator in statistical and methods analysis

Methods and statistical reviewer

McAfee, Darrian

University of Pennsylvania, Philadelphia

Collaborator in english style

English style reviewer

Meitín, Maria Teresa

Hospital Da Costa de Burela, Lugo, Spain

Site investigator

Evaluation of participants and/or data management

Menéndez González, Manuel

Hospital Universitario Central de Asturias, Oviedo, Spain

Site investigator / PI

Coordination at the center

Evaluation of participants and/or data management

Méndez del Barrio, Carlota

Hospital Universitario Virgen del Rocío, Sevilla, Spain

Site investigator

Evaluation of participants and/or data management

Mendoza Plasencia, Zebenzui

Hospital Universitario de Canarias, San Cristóbal de la Laguna, Santa Cruz de Tenerife, Spain

Site investigator

Evaluation of participants and/or data management

Mir, Pablo

Hospital Universitario Virgen del Rocío, Sevilla, Spain

Site investigator / PI

Coordination at the center

Evaluation of participants and/or data management

Miranda Santiago, Javier

Complejo Asistencial Universitario de Burgos, Burgos, Spain

Site investigator

Evaluation of participants and/or data management

Morales Casado, Maria Isabel

Complejo Hospitalario de Toledo, Toledo, Spain

Site investigator

Evaluation of participants and/or data management

Moreno Diéguez, Antonio

Complejo Hospitalario Universitario de Ferrol (CHUF), Ferrol, A Coruña, Spain

Site investigator

Neuroimaging studies

Muro García, Inés

Hospital La Princesa, Madrid, Spain

Site investigator (from MAR/23)

Evaluation of participants and/or data management

Nogueira, Víctor

Hospital Da Costa de Burela, Lugo, Spain

Site investigator / PI (until 2022)**

Coordination at the center

Evaluation of participants and/or data management

Novo Amado, Alba

Complejo Hospitalario Universitario de Ferrol (CHUF), Ferrol, A Coruña, Spain

Site investigator

Neuroimaging studies

Novo Ponte, Sabela

Hospital Universitario Puerta de Hierro, Madrid, Spain

Site investigator

Evaluation of participants and/or data management

Ordás, Carlos

Hospital Rey Juan Carlos, Madrid, Spain, Madrid, Spain

Site Investigator

Evaluation of participants and/or data management

Pagonabarraga, Javier

Hospital de Sant Pau, Barcelona, Spain

Site investigator

Evaluation of participants and/or data management

Pareés, Isabel

Hospital Ruber Internacional, Madrid, Spain

Site investigator

Evaluation of participants and/or data management

Pascual-Sedano, Berta

Hospital de Sant Pau, Barcelona, Spain

Site Investigator

Evaluation of participants and/or data management

Pastor, Pau

Hospital Universitari Mutua de Terrassa, Terrassa, Barcelona, Spain

Site investigator

Evaluation of participants and/or data management

Pérez Fuertes, Aída

Complejo Hospitalario Universitario de Ferrol (CHUF), Ferrol, A Coruña, Spain

Site investigator

Blood analysis

Pérez Noguera, Rafael

Hospital Universitario Virgen Macarena, Sevilla, Spain

Site investigator

Evaluation of participants and/or data management

Planas-Ballvé, Ana

Consorci Sanitari Integral, Hospital Moisés Broggi, Sant Joan Despí, Barcelona, Spain

Site investigator

Evaluation of participants and/or data management

Planellas, Lluís

Hospital Clínic de Barcelona, Barcelona, Spain

Site investigator (until DEC/19)

Evaluation of participants and/or data management

Prats, Marian Ángeles

Institut d'Assistència Sanitària (IAS)—Instituí Cátala de la Salud. Girona, Spain

Site investigator

Evaluation of participants and/or data management

Prieto Jurczynska, Cristina

Hospital Rey Juan Carlos, Madrid, Spain, Madrid, Spain

Site investigator / PI

Coordination at the center

Evaluation of participants and/or data management

Puente, Víctor

Hospital del Mar, Barcelona, Spain

Site investigator / PI

Coordination at the center

Evaluation of participants and/or data management

Pueyo Morlans, Mercedes

Hospital Universitario de Canarias, San Cristóbal de la Laguna, Santa Cruz de Tenerife, Spain

Site investigator

Evaluation of participants and/or data management

Puig Daví, Arnau

Hospital de Sant Pau, Barcelona, Spain

Site einvestigator

Evaluation of participants and/or data management

Redondo, Nuria

Hospital La Princesa, Madrid, Spain

Site Investigator

Evaluation of participants and/or data management

Rodríguez Méndez, Luisa

Complejo Hospitalario Universitario de Ferrol (CHUF), Ferrol, A Coruña, Spain

Site investigator

Blood analysis

Rodríguez Pérez, Amparo Belén

Hospital General Universitario de Elche, Elche, Spain

Site investigator

Evaluation of participants and/or data management

Roldán, Florinda

Hospital Universitario Virgen del Rocío, Sevilla, Spain

Site investigator

Neuroimaging studies

Ruíz de Arcos, María

Hospital Universitario Virgen Macarena, Sevilla, Spain

Site investigator

Evaluation of participants and/or data management

Ruíz Martínez, Javier

Hospital Universitario Donostia, San Sebastián, Spain

Site investigator

Evaluation of participants and/or data management

Sánchez Alonso, Pilar

Hospital Universitario Puerta de Hierro, Madrid, Spain

Site investigator

Evaluation of participants and/or data management

Sánchez-Carpintero, Macarena

Complejo Hospitalario Universitario de Ferrol (CHUF), Ferrol, A Coruña, Spain

Site investigator

Neuroimaging studies

Sánchez D��ez, Gema

Hospital Universitario Ramón y Cajal, Madrid, Spain

Site investigator

Evaluation of participants and/or data management

Sánchez Rodríguez, Antonio

Hospital Universitario Marqués de Valdecilla, Santander, Spain

Site investigator

Evaluation of participants and/or data management

Santacruz, Pilar

Hospital Clínic de Barcelona, Barcelona, Spain

Site investigator

Evaluation of participants and/or data management

Santos García, Diego

CHUAC, Complejo Hospitalario Universitario de A Coruña

Coordinator of the Project

Coordination of the COPPADIS-2015

Segundo Rodríguez, José Clemente

Complejo Hospitalario de Toledo, Toledo, Spain

Site investigator

Evaluation of participants and/or data management

Seijo, Manuel

Complejo Hospitalario Universitario de Pontevedra (CHOP), Pontevedra, Spain

Site investigator / PI

Coordination at the center

Evaluation of participants and/or data management

Sierra, María

Hospital Universitario Marqués de Valdecilla, Santander, Spain

Site investigator

Evaluation of participants and/or data management

Solano, Berta

Institut d'Assistència Sanitària (IAS)—Instituí Cátala de la Salud. Girona, Spain

Site investigator / PI

Coordination at the center

Evaluation of participants and/or data management

Suárez Castro, Ester

Complejo Hospitalario Universitario de Ferrol (CHUF), Ferrol, A Coruña, Spain

Site investigator

Evaluation of participants and/or data management

Tartari, Juan Pablo

Hospital Universitari Mutua de Terrassa, Terrassa, Barcelona, Spain

Site investigator

Evaluation of participants and/or data management

Valero, Caridad

Hospital Arnau de Vilanova, Valencia, Spain

Site investigator

Evaluation of participants and/or data management

Vargas, Laura

Hospital Universitario Virgen del Rocío, Sevilla, Spain

Site investigator

Evaluation of participants and/or data management

Vela, Lydia

Fundación Hospital de Alcorcón, Madrid, Spain

Site investigator / PI

Coordination at the center

Evaluation of participants and/or data management

Villanueva, Clara

Hospital Universitario Clínico San Carlos, Madrid, Spain

Site investigator

Evaluation of participants and/or data management

Vives, Bárbara

Hospital Universitario Son Espases, Palma de Mallorca, Spain

Site investigator

Evaluation of participants and/or data management

  1. *Neurology Department, Institute of Neuroscience, Vithas Madrid La Milagrosa University Hospital, Vithas Hospital Group. Madrid, Spain
  2. **Neurology Department, Hospital Universitario Lucus Augusti, Lugo, Spain

Funding

COPPADIS and the present study were developed with the help of Fundación Española de Ayuda a la Investigación en Enfermedades Neurodegenerativas y/o de Origen Genético (https://fundaciondegen.org/) and Alpha Bioresearch (www.alphabioresearch.com). Also, we received grants from the Spanish Ministry of Economy and Competitiveness [PI16/01575] co-founded by ISCIII (Concesión de subvenciones de Proyectos de Investigación en Salud de la convocatoria 2020 de la Acción Estratégica en Salud 2017–2020 por el Proyecto “PROGRESIÓN NO MOTORA E IMPACTO EN LA CALIDAD DE VIDA EN LA ENFERMEDAD DE PARKINSON”) to develop a part of the COPPADIS project.

Author information

Authors and Affiliations

  1. CHUAC, Complejo Hospitalario Universitario de A Coruña, A Coruña, Spain

    Diego Santos-García, Carlos Cores Bartolomé, María J. Feal Painceiras, Iago García Díaz, María Cristina Íñiguez Alvarado & Jose Manuel Paz

  2. CHUF, Complejo Hospitalario Universitario de Ferrol, A Coruña, Spain

    Teresa de Deus Fonticoba

  3. Servicio de Neurología y Neurofisiología Clínica, Unidad de Trastornos del Movimiento, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain

    Silvia Jesús & Pablo Mir

  4. CIBERNED (Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas), A Coruña, Spain

    Silvia Jesús, Jorge Hernández Vara, Isabel González Aramburu, Jaime Kulisevsky, Pablo Martinez-Martin & Pablo Mir

  5. Hospital Clínic de Barcelona, Barcelona, Spain

    Marina Cosgaya

  6. Centro Neurológico Oms 42, Palma, Spain

    Juan García Caldentey

  7. Consorci Sanitari Integral, Hospital Moisés Broggi, Sant Joan Despí, Barcelona, Spain

    Nuria Caballol

  8. Hospital Universitario Son Espases, Palma, Spain

    Ines Legarda

  9. Hospital Universitario Vall d’Hebron, Barcelona, Spain

    Jorge Hernández Vara

  10. Complejo Hospitalario Universitario de Pontevedra (CHOP), Pontevedra, Spain

    Iria Cabo & Manuel Seijo

  11. Hospital Universitario La Princesa, Madrid, Spain

    Lydia López Manzanares

  12. Hospital Universitario Marqués de Valdecilla-IDIVAL, Santander, Spain

    Isabel González Aramburu

  13. Consorci Sanitari Integral, Hospital General de L’Hospitalet, L’Hospitalet de Llobregat, Barcelona, Spain

    Maria A. Ávila Rivera

  14. Neurology Department, Institute of Neuroscience, Vithas Madrid La Milagrosa University Hospital, Vithas Hospital Group, Madrid, Spain

    Víctor Gómez Mayordomo

  15. Hospital Universitario Lucus Augusti, Lugo, Spain

    Víctor Nogueira & Ruben Alonso Redondo

  16. Hospital Universitario Virgen Macarena, Seville, Spain

    Julio Dotor García-Soto

  17. Hospital Infanta Sofía, Madrid, Spain

    Carmen Borrué

  18. Institut d’Assistència Sanitària (IAS), Institut Català de la Salut, Girona, Spain

    Berta Solano Vila

  19. Hospital General Universitario de Elche, Elche, Spain

    María Álvarez Sauco

  20. Fundación Hospital de Alcorcón, Madrid, Spain

    Lydia Vela

  21. Hospital de Tortosa Verge de la Cinta (HTVC), Tortosa, Tarragona, Spain

    Sonia Escalante

  22. Complejo Asistencial Universitario de Burgos, Burgos, Spain

    Esther Cubo

  23. Hospital Universitario de Canarias, San Cristóbal de la Laguna, Santa Cruz de Tenerife, Spain

    Zebenzui Mendoza

  24. Hospital Universitario Ramón y Cajal, IRYCIS, Madrid, Spain

    Juan C. Martínez Castrillo

  25. Hospital Universitario Puerta de Hierro, Madrid, Spain

    Pilar Sánchez Alonso

  26. Hospital Álvaro CunqueiroComplejo Hospitalario Universitario de Vigo (CHUVI), Vigo, Spain

    Maria G. Alonso Losada

  27. Complejo Hospitalario de Toledo, Toledo, Spain

    Nuria López Ariztegui

  28. Complejo Hospitalario de Navarra, Pamplona, Spain

    Itziar Gastón

  29. Hospital de Sant Pau, Barcelona, Spain

    Jaime Kulisevsky

  30. Hospital Arnau de Vilanova, Valencia, Spain

    Caridad Valero

  31. Hospital Universitari Mutua de Terrassa, Terrassa, Barcelona, Spain

    Maria Teresa Buongiorno

  32. Hospital Rey Juan Carlos, Madrid, Spain

    Carlos Ordás

  33. Hospital Universitario Central de Asturias, Oviedo, Spain

    Manuel Menéndez-González

  34. University of Maryland School of Medicine, College Park, USA

    Darrian McAfee

  35. Department of Neurology, Hospital Universitario de A Coruña (HUAC), Complejo Hospitalario Universitario de A Coruña (CHUAC), C/As Xubias 84, 15006, A Coruña, Spain

    Diego Santos-García

Authors
  1. Diego Santos-García
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Teresa de Deus Fonticoba
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Carlos Cores Bartolomé
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. María J. Feal Painceiras
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Iago García Díaz
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. María Cristina Íñiguez Alvarado
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Jose Manuel Paz
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Silvia Jesús
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Marina Cosgaya
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Juan García Caldentey
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Nuria Caballol
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. Ines Legarda
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. Jorge Hernández Vara
    View author publications

    You can also search for this author in PubMed Google Scholar

  14. Iria Cabo
    View author publications

    You can also search for this author in PubMed Google Scholar

  15. Lydia López Manzanares
    View author publications

    You can also search for this author in PubMed Google Scholar

  16. Isabel González Aramburu
    View author publications

    You can also search for this author in PubMed Google Scholar

  17. Maria A. Ávila Rivera
    View author publications

    You can also search for this author in PubMed Google Scholar

  18. Víctor Gómez Mayordomo
    View author publications

    You can also search for this author in PubMed Google Scholar

  19. Víctor Nogueira
    View author publications

    You can also search for this author in PubMed Google Scholar

  20. Julio Dotor García-Soto
    View author publications

    You can also search for this author in PubMed Google Scholar

  21. Carmen Borrué
    View author publications

    You can also search for this author in PubMed Google Scholar

  22. Berta Solano Vila
    View author publications

    You can also search for this author in PubMed Google Scholar

  23. María Álvarez Sauco
    View author publications

    You can also search for this author in PubMed Google Scholar

  24. Lydia Vela
    View author publications

    You can also search for this author in PubMed Google Scholar

  25. Sonia Escalante
    View author publications

    You can also search for this author in PubMed Google Scholar

  26. Esther Cubo
    View author publications

    You can also search for this author in PubMed Google Scholar

  27. Zebenzui Mendoza
    View author publications

    You can also search for this author in PubMed Google Scholar

  28. Juan C. Martínez Castrillo
    View author publications

    You can also search for this author in PubMed Google Scholar

  29. Pilar Sánchez Alonso
    View author publications

    You can also search for this author in PubMed Google Scholar

  30. Maria G. Alonso Losada
    View author publications

    You can also search for this author in PubMed Google Scholar

  31. Nuria López Ariztegui
    View author publications

    You can also search for this author in PubMed Google Scholar

  32. Itziar Gastón
    View author publications

    You can also search for this author in PubMed Google Scholar

  33. Jaime Kulisevsky
    View author publications

    You can also search for this author in PubMed Google Scholar

  34. Manuel Seijo
    View author publications

    You can also search for this author in PubMed Google Scholar

  35. Caridad Valero
    View author publications

    You can also search for this author in PubMed Google Scholar

  36. Ruben Alonso Redondo
    View author publications

    You can also search for this author in PubMed Google Scholar

  37. Maria Teresa Buongiorno
    View author publications

    You can also search for this author in PubMed Google Scholar

  38. Carlos Ordás
    View author publications

    You can also search for this author in PubMed Google Scholar

  39. Manuel Menéndez-González
    View author publications

    You can also search for this author in PubMed Google Scholar

  40. Darrian McAfee
    View author publications

    You can also search for this author in PubMed Google Scholar

  41. Pablo Martinez-Martin
    View author publications

    You can also search for this author in PubMed Google Scholar

  42. Pablo Mir
    View author publications

    You can also search for this author in PubMed Google Scholar

Consortia

COPPADIS Study Group

  • A. D. Adarmes
  • , M. Almeria
  • , M. G. Alonso Losada
  • , A. Alonso Cánovas
  • , F. Alonso Frech
  • , R. Alonso Redondo
  • , I. Álvarez
  • , M. Álvarez Sauco
  • , A. Aneiros Díaz
  • , S. Arnáiz
  • , S. Arribas
  • , A. Ascunce Vidondo
  • , M. Aguilar
  • , M. A. Ávila
  • , N. Nernardo Lambrich
  • , H. Bejr-Kasem
  • , M. Blázquez Estrada
  • , M. Botí
  • , C. Borrue
  • , M. T. Buongiorno
  • , C. Cabello González
  • , I. Cabo López
  • , N. Caballol
  • , A. Cámara Lorenzo
  • ,��H. Canfield Medina
  • , E. Carabajal Pendón
  • , F. Carrillo
  • , F. J. Carrillo Padilla
  • , E. Casas
  • , M. J. Catalán
  • , P. Clavero
  • , A. Cortina Fernández
  • , M. Cosgaya
  • , A. Cots Foraster
  • , A. Crespo Cuevas
  • , E. Cubo
  • , T. de Deus Fonticoba
  • , O. de Fábregues-Boixar
  • , M. Díez-Fairen
  • , J. Dotor García-Soto
  • , E. Erro
  • , S. Escalante
  • , EEstelrich Peyret
  • , N. Fernández Guillán
  • , P. Gámez
  • , M. Gallego
  • , J. García Caldentey
  • , C. García Campos
  • , C. García Díez
  • , J. M. García Moreno
  • , I. Gastón
  • , M. P. Gómez Garre
  • , V. Gómez Mayordomo
  • , J. González Aloy
  • , I. González-Aramburu
  • , J. González Ardura
  • , B. González García
  • , M. J. González Palmás
  • , G. R. González Toledo
  • , A. Golpe Díaz
  • , M. Grau Solá
  • , G. Guardia
  • , J. Hernández Vara
  • , A. Horta-Barba
  • , DIdoate Calderón
  • , J. Infante
  • , S. Jesús
  • , J. Kulisevsky
  • , M. Kurtis
  • , C. Labandeira
  • , M. A. Labrador
  • , F. Lacruz
  • , M. Lage Castro
  • , S. Lastres Gómez
  • , I. Legarda
  • , NLópez Ariztegui
  • , L. M. López Díaz
  • , D. López Domínguez
  • , L. López Manzanares
  • , B. López Seoane
  • , S. Lucas del Pozo
  • , Y. Macías
  • , M. Mata
  • , G. Martí Andres
  • , M. J. Martí
  • , J. C. Martínez Castrillo
  • , P. Martinez-Martin
  • , D. McAfee
  • , M. T. Meitín
  • , Z. Mendoza Plasencia
  • , M. Menéndez González
  • , C. Méndez del Barrio
  • , P. Mir
  • , J. Miranda Santiago
  • , M. I. Morales Casado
  • , A. Moreno Diéguez
  • , I. Muro García
  • , V. Nogueira
  • , A. Novo Amado
  • , S. Novo Ponte
  • , C. Ordás
  • , J. Pagonabarraga
  • , I. Pareés
  • , B. Pascual-Sedano
  • , P. Pastor
  • , A. Pérez Fuertes
  • , R. Pérez Noguera
  • , A. Planas-Ballvé
  • , L. Planellas
  • , M. A. Prats
  • , C. Prieto Jurczynska
  • , V. Puente
  • , M. Pueyo Morlans
  • , A. Puig Daví
  • , N. Redondo Rafales
  • , L. Rodríguez Méndez
  • , ABRodríguez Pérez
  • , F. Roldán
  • , M. Ruíz De Arcos
  • , J. Ruíz Martínez
  • , P. Sánchez Alonso
  • , M. Sánchez-Carpintero
  • , G. Sánchez Díez
  • , A. Sánchez Rodríguez
  • , P. Santacruz
  • , D. Santos García
  • , J. C. Segundo Rodríguez
  • , M. Seijo
  • , M. Sierra Peña
  • , B. Solano Vila
  • , E. Suárez Castro
  • , J. P. Tartari
  • , C. Valero
  • , L. Vargas
  • , L. Vela
  •  & C. Villanueva

Contributions

DS-G: conception, organization, and execution of the project; statistical analysis; writing of the first draft of the manuscript; recruitment and/or evaluation of participants. TDF: review and critique; recruitment and/or evaluation of participants and/or data entry into eCRF. CCB: collaboration in the preparation of the manuscript. Review and critique. MJFP: collaboration in the preparation of the manuscript. Review and critique. IGD: collaboration in the preparation of the manuscript. Review and critique. MCÍA: collaboration in the preparation of the manuscript. Review and critique. JMP: collaboration in the preparation of the manuscript. Review and critique. SJ: review and critique; recruitment and/or evaluation of participants and/or data entry into eCRF. MC: review and critique; recruitment and/or evaluation of participants and/or data entry into eCRF. JGC: review and critique; recruitment and/or evaluation of participants and/or data entry into eCRF. NC: review and critique; recruitment and/or evaluation of participants and/or data entry into eCRF. IL: review and critique; recruitment and/or evaluation of participants and/or data entry into eCRF. JHV: review and critique; recruitment and/or evaluation of participants and/or data entry into eCRF. IC: review and critique; recruitment and/or evaluation of participants and/or data entry into eCRF. LLM: review and critique; recruitment and/or evaluation of participants and/or data entry into eCRF. IGA: review and critique; recruitment and/or evaluation of participants and/or data entry into eCRF. MAÁR: review and critique; recruitment and/or evaluation of participants and/or data entry into eCRF. VGM: review and critique; recruitment and/or evaluation of participants and/or data entry into eCRF. VN: review and critique; recruitment and/or evaluation of participants and/or data entry into eCRF. JDG-S: review and critique; recruitment and/or evaluation of participants and/or data entry into eCRF. CB: review and critique; recruitment and/or evaluation of participants and/or data entry into eCRF. BSV: review and critique; recruitment and/or evaluation of participants and/or data entry into eCRF. MÁS: review and critique; recruitment and/or evaluation of participants and/or data entry into eCRF. LV: review and critique; recruitment and/or evaluation of participants and/or data entry into eCRF. SE: review and critique; recruitment and/or evaluation of participants and/or data entry into eCRF. EC: review and critique; recruitment and/or evaluation of participants and/or data entry into eCRF. ZM: review and critique; recruitment and/or evaluation of participants and/or data entry into eCRF. JCMC: review and critique; recruitment and/or evaluation of participants and/or data entry into eCRF. PSA: review and critique; recruitment and/or evaluation of participants and/or data entry into eCRF. MGAL: review and critique; recruitment and/or evaluation of participants and/or data entry into eCRF. NLA: review and critique; recruitment and/or evaluation of participants and/or data entry into eCRF. IG: review and critique; recruitment and/or evaluation of participants and/or data entry into eCRF. JK: review and critique; recruitment and/or evaluation of participants and/or data entry into eCRF. MS: review and critique; recruitment and/or evaluation of participants and/or data entry into eCRF. CV: review and critique; recruitment and/or evaluation of participants and/or data entry into eCRF. RAR: review and critique; recruitment and/or evaluation of participants and/or data entry into eCRF. MTB: review and critique; recruitment and/or evaluation of participants and/or data entry into eCRF. CO: review and critique; recruitment and/or evaluation of participants and/or data entry into eCRF. MM-G: review and critique; recruitment and/or evaluation of participants and/or data entry into eCRF. DM: English edition; review and critique. PM-M: Review and critique. PM: review and critique; recruitment and/or evaluation of participants and/or data entry into eCRF. COPPADIS study group: recruitment and/or evaluation of participants and/or data entry into eCRF.

Corresponding author

Correspondence to Diego Santos-García.

Ethics declarations

Conflicts of interest

Diego Santos-García has received honoraria for educational presentations and advice service by Abbvie, UCB Pharma, Lundbeck, KRKA, Zambon, Bial, Italfarmaco, Teva, Archímedes, Esteve, Stada, Merz, and grants from the Spanish Ministry of Economy and Competitiveness [PI16/01575] co-founded by ISCIII (Concesión de subvenciones de Proyectos de Investigación en Salud de la convocatoria 2020 de la Acción Estratégica en Salud 2017–2020 por el proyecto “PROGRESIÓN NO MOTORA E IMPACTO EN LA CALIDAD DE VIDA EN LA ENFERMEDAD DE PARKINSON”). Teresa de Deus Fonticoba: None. Carlos Cores Bartolomé has received honoraria for educational presentations and advice service by Lundbeck and UCB Pharma. María J. Feal Painceiras: None. Iago García Díaz has received support for educational activity from Bial. María Cristina Íñiguez Alvarado: None. Jose Manuel Paz has received honoraria/support for educational presentations and attending meetings from UCB, Abbvie, Zambon, Bial, and KRKA. Silvia Jesús has received honoraria from AbbVie, Bial, Merz, UCB, and Zambon and holds the competitive contract "Juan Rodés" supported by the Instituto de Salud Carlos III. She has received grants from the Spanish Ministry of Economy and Competitiveness (PI18/01898) and the Consejería de Salud de la Junta de Andalucía (PI-0459-2018). Marina Cosgaya: None. Juan García Caldentey has received honoraria for educational presentations and advice service by Qualigen, Nutricia, Abbvie, Italfarmaco, UCB Pharma, Lundbeck, Zambon, Bial, and Teva. Nuria Caballol has received honoraria from Bial, Italfármaco, Qualigen, Zambon, UCB, Teva and KRKA and sponsorship from Zambon, TEVA and Abbvie for attending medical conferences. Ines Legarda has received honoraria for educational presentations and advice service by Abbvie, UCB Pharma, Zambon, Bial, and Teva. Jorge Hernández Vara has received travel bursaries and educational grants from Abbvie and has received honoraria for educational presentations from Abbvie, Teva, Bial, Zambon, Italfarmaco, and Sanofi-Genzyme. Iria Cabo: has received honoraria for educational presentations and advice service by Abbvie, Zambon, and Bial. Lydia López Manzanares compensated advisory services, consulting, research grant support, or speaker honoraria: AbbVie, Acorda, Bial, Intec Pharma, Italfarmaco, Pfizer, Roche, Teva, UCB, and Zambon. Isabel González Aramburu: None. Maria A. Ávila Rivera has received honoraria from Zambon, UCB Pharma, Qualigen, Bial, and Teva, and sponsorship from Zambon and Teva for attending conferences. Víctor Gómez Mayordomo has received honoraria from Bial, Merz, and Zambon for educational lectures. Víctor Nogueira: None. Julio Dotor García-Soto compensated advisory services, consulting, research grant support, or speaker honoraria: Merck, Sanofi-Genzyme, Allergan, Biogen, Roche, UCB and Novartis. Carmen Borrué: None. Berta Solano Vila has received honoraria for educational presentations and advice service by UCB, Zambon, Teva, Abbvie, Bial. María Álvarez Sauco has received honoraria for educational presentations and advice service by Abbvie, UCB Pharma, Zambon, Bial, and Teva. Lydia Vela has received honoraria for educational presentations and advice service by Abbvie, UCB Pharma, Lundbeck, KRKA, Zambon, Bial, and Teva. Sonia Escalante has received honoraria for educational presentations and advice service by Abbvie, Zambon, and Bial. Esther Cubo: Travel grants: Abbvie, Allergan, Boston; Lecturing honoraria: Abbvie, International Parkinson´s disease Movement Disorder Society. Zebenzui Mendoza: None. Juan C. Martínez Castrillo has received research support from Lundbeck, Italfarmaco, Allergan, Zambon, Merz, and Abbvie. He has received speaking honoraria from AbbVie, Bial, Italfarmaco, Lundbeck, Krka, TEVA, UCB, Zambon, Allergan, Ipsen, and Merz. Pilar Sánchez Alonso has received honoraria for educational presentations and advice service by Abbvie, UCB Pharma, Lundbeck, KRKA, Zambon, Bial, and Teva. Maria G. Alonso Losada has received honoraria for educational presentations and advice service by Zambon and Bial. Nuria López Ariztegui has received honoraria for educational presentations and advice service by Abbvie, Italfarmaco, Zambon, and Bial. Itziar Gastón has received research support from Abbvie and Zambon and has served as a consultant for Abbvie, Exelts, and Zambon. Jaime Kulisevsky: (1) Consulting fees: Roche, Zambon; (2) Stock/allotment: No; (3) Patent royalties/licensing fees: No; (4) Honoraria (e.g., lecture fees): Zambon, Teva, Bial, UCB; (5) Fees for promotional materials: No; (6) Research funding: Roche, Zambon, Ciberned; Instituto de SaludCarlos III; FundacióLa Maratóde TV3; (7) Scholarship from corporation: No; (8) Corporate laboratory funding: No; (9) Others (e.g., trips, travel, or gifts): No. Manuel Seijo has received honoraria for educational services from KRKA, UCB, Zambon, Bial; travel grants from Daiichi and Roche. Caridad Valero has received honoraria for educational services from Zambon, Abbvie and UCB. Kurtis M. has received honoraria from Bial, the Spanish Neurology Society, and the International and Movement Disorders Society. Ruben Alonso Redondo: None. Maria Teresa Buongiorno: None. Carlos Ordás: None. Manuel Menéndez-González has received consulting honoraria from Eisai Spain and research grants from by Instituto de Salud Carlos III (ISCIII), Fondo Europeo de Desarrollo Regional (FEDER), and Fundación Alimerka. Darrian McAfee: None. Pablo Martinez-Martin has received honoraria from Bial for lecturing in course and from the Parkinson and Movement Disorder Society (MDS) for management of the COA International Program of the Society. Pablo Mir has received honoraria from AbbVie, Abbott, Allergan, Bial, Merz, UCB, and Zambon and have received grants from the Spanish Ministry of Economy and Competitiveness [PI16/01575] co-founded by ISCIII (Subdirección General de Evaluación y Fomento de la Investigación) and by Fondo Europeo de Desarrollo Regional (FEDER), the Consejería de Economía, Innovación, Ciencia y Empleo de la Junta de Andalucía [CVI-02526, CTS-7685], the Consejería de Salud y Bienestar Social de la Junta de Andalucía [ PI-0437–2012, PI-0471–2013], the Sociedad Andaluza de Neurología, the Jacques and Gloria Gossweiler Foundation, the Fundación Alicia Koplowitz, and the Fundación Mutua Madrileña.

Additional information

The members of the instutional group “COPPADIS Study Group” was processed under Acknowledgement section.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Santos-García, D., de Deus Fonticoba, T., Cores Bartolomé, C. et al. Cognitive impairment and dementia in young onset Parkinson’s disease. J Neurol 270, 5793–5812 (2023). https://doi.org/10.1007/s00415-023-11921-w

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00415-023-11921-w

Keywords

Search

Navigation