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Neuroimaging studies in persistent postural–perceptual dizziness and related disease: a systematic review

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Abstract

Background

Persistent Postural–Perceptual Dizziness (PPPD) is one of the most common types of chronic dizziness. The pathogenesis remains unclear.

Objective

This study aimed to systematically review neuroimaging literature for investigating the central mechanism of PPPD and related disorders.

Methods

PubMed, EMBASE, Medline, Cochrane, and Web of Science were searched by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The articles analyzing structural and functional neuroimaging features of PPPD and related disorders were selected according to eligibility criteria.

Results

Fifteen articles, including 4 structural, 10 functional, and 1 multimodal imaging, were eligible for inclusion in this review. The whiter matter alterations in PPPD are not entirely consistent. The changes of grey matter mainly in multisensory vestibular cortices, visual cortex, cerebellum, as well as anxiety-related network. Consistent with structural imaging, functional imaging conducted during the specific tasks or in the resting state has both found abnormal functional activation and connectivity in the vestibular cortex, especially in the parieto-insular vestibular cortex (PIVC), visual cortex, cerebellum, and anxiety-related network in PPPD and related disorder.

Conclusions

The current review provides up-to-date knowledge and summarizes the possible central mechanism for PPPD and related disorders, and it is helpful to understanding the mechanism of PPPD.

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Data availability statement

Any data associated with this review article will be made available by reasonable request to the corresponding author.

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Funding

This research was supported by CAMS Innovation Fund for Medical Sciences (2019-I2M-5-029), Beijing Municipal Committee of Science and Technology (Z201100005620010), National Science and Technology Major Project (2017ZX09304018), and National Key Research and Development Program of China (Grant No.2018YFC1312200/2018YFC1312204).

Author information

Authors and Affiliations

  1. Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, No.119, South 4th Ring West Road, Fengtai District, Beijing, 100070, China

    Zhentang Cao, Xinmin Liu, Yi Ju & Xingquan Zhao

  2. China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

    Zhentang Cao, Xinmin Liu, Yi Ju & Xingquan Zhao

  3. Clinical Center for Vertigo and Balance Disturbance, Capital Medical University, Beijing, China

    Yi Ju & Xingquan Zhao

Authors
  1. Zhentang Cao
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  2. Xinmin Liu
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  3. Yi Ju
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  4. Xingquan Zhao
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Correspondence to Yi Ju or Xingquan Zhao.

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Cao, Z., Liu, X., Ju, Y. et al. Neuroimaging studies in persistent postural–perceptual dizziness and related disease: a systematic review. J Neurol 269, 1225–1235 (2022). https://doi.org/10.1007/s00415-021-10558-x

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  • DOI: https://doi.org/10.1007/s00415-021-10558-x

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