Abstract
Background
The association between human papillomavirus (HPV) and anogenital tumors, especially cervical cancer, is well documented. However, it remains unclear whether there is also a correlation between HPV infection and human breast cancer.
Methods
We used PCR and Southern blot hybridization to analyze HPV-related DNA specimens from 32 cases of invasive ductal carcinoma operated upon in the Shanghai region of China.
Results
DNA derived from HPV33 was detected in 14 cases (43.8%). No HPV16 or HPV18 DNA was detected in any of the cases in this study. This is the first report demonstrating a correlation between HPV33 infection and breast cancer.
Conclusions
Our results suggest that HPV33 infection may be involved in the pathogenesis of breast cancer in Chinese.
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Abbreviations
- HPV:
-
Human papillomavirus
- DNA:
-
Deoxyribonucleic acid
- PCR:
-
Polymerase chain reaction
- G3PDH:
-
Glyceraldehyde 3-phosphate dehydrogenase
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Yu, Y., Morimoto, T., Sasa, M. et al. Human papillomavirus type 33 dna in breast cancer in Chinese. Breast Cancer 7, 33–36 (2000). https://doi.org/10.1007/BF02967185
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DOI: https://doi.org/10.1007/BF02967185