Abstract
Ferroptosis is defined as an iron-dependent regulated form of cell death driven by lipid peroxidation. In the past decade, it has been implicated in the pathogenesis of various diseases that together involve almost every organ of the body, including various cancers, neurodegenerative diseases, cardiovascular diseases, lung diseases, liver diseases, kidney diseases, endocrine metabolic diseases, iron-overload-related diseases, orthopedic diseases and autoimmune diseases. Understanding the underlying molecular mechanisms of ferroptosis and its regulatory pathways could provide additional strategies for the management of these disease conditions. Indeed, there are an expanding number of studies suggesting that ferroptosis serves as a bona-fide target for the prevention and treatment of these diseases in relevant pre-clinical models. In this review, we summarize the progress in the research into ferroptosis and its regulatory mechanisms in human disease, while providing evidence in support of ferroptosis as a target for the treatment of these diseases. We also discuss our perspectives on the future directions in the targeting of ferroptosis in human disease.
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Acknowledgements
The authors receive support from the National Natural Science Foundation of China (No. 31930057 to Fudi Wang and No. 31970689 to Junxia Min), the National Key R&D Program (No. 2018YFA0507801 to Junxia Min and No. 2018YFA0507802 to Fudi Wang) and the China Postdoctoral Science Foundation (No. 2022M712733 to Xue Wang). The authors thank Hao Wang (Zhengzhou University School of Public Health, China), Xuexian Fang (Hangzhou Normal University School of Public Health, China), Yingying Yu, Enjun Xie, and Xinquan Yang (Zhejiang University School of Medicine, China) for their contribution to the discussion for this review.
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Xue Wang, Ye Zhou, Junxia Min, and Fudi Wang declare that they have no conflict of interest. This manuscript is a review article, and it does not involve a research protocol requiring approval by the relevant institutional review board or ethics committee.
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Wang, X., Zhou, Y., Min, J. et al. Zooming in and out of ferroptosis in human disease. Front. Med. 17, 173–206 (2023). https://doi.org/10.1007/s11684-023-0992-z
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DOI: https://doi.org/10.1007/s11684-023-0992-z