Abstract
Peroxisomes are dynamic organelles essential for optimum functioning of a eukaryotic cell. Biogenesis of these organelles and the diverse functions performed by them have been extensively studied in the past decade. Their ability to perform functions depending on the cell type and growth conditions is unique and remarkable. Oxidation of fatty acids and reactive oxygen species metabolism are the two most important functions of these ubiquitous organelles. They are often referred to as both source and sink of reactive oxygen species in a cell. Recent research connects peroxisome dysfunction to fatal oxidative damage associated with ageing-related diseases/disorders. It is now widely accepted that mitochondria and peroxisomes are required to maintain oxidative balance in a cell. However, our understanding on the inter-dependence of these organelles to maintain cellular homeostasis of reactive oxygen species is still in its infancy. Herein, we summarize findings that highlight the role of peroxisomes in cellular reactive oxygen species metabolism, ageing and age-related disorders.
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Abbreviations
- ACOX:
-
Acyl-CoA oxidase
- AD:
-
Alzheimer’s disease
- Atg1:
-
Autophagy related 1
- ATM:
-
Ataxia-telangiectasia mutated
- ATP:
-
Adenosine triphosphate
- CCP:
-
Cytochrome-c peroxidase
- CHO:
-
Chinese hamster ovary
- CLS:
-
Chronological lifespan
- DLP:
-
Dynamin like protein
- ER:
-
Endoplasmic reticulum
- FAD:
-
Flavin adenine dinucleotide
- FMN:
-
Flavin mononucleotide
- GAP:
-
GTPase activating protein
- GSH:
-
Glutathione (reduced)
- GSSG:
-
Glutathione (oxidized)
- H2O2 :
-
Hydrogen peroxide
- HDF:
-
Human diploid fibroblast
- MAVS:
-
Mitochondrial antiviral signaling protein
- mTORC1:
-
Mammalian target of rapamycin complex 1
- NADPH:
-
Nicotinamide adenine dinucleotide phosphate
- PBD:
-
Peroxisomal biogenesis disorder
- PD:
-
Parkinson’s disease
- PMP:
-
Peroxisomal membrane protein
- PRDX5:
-
Peroxiredoxin 5
- PTS:
-
Peroxisomal targeting signal
- RNS:
-
Reactive nitrogen species
- ROS:
-
Reactive oxygen species
- SOD:
-
Superoxide dismutase
- TSC:
-
Tuberous sclerosis
- VLFCA:
-
Very long chain fatty acid
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Acknowledgements
Our sincere apologies to all our colleagues for any publication not being cited which is due to space limitation. We would also like to thank the members of Organelle Biology and Cellular Ageing Lab (OBCAL), Indian Institute of Technology Guwahati for their critical reading of the manuscript. This work was supported by Department of Biotechnology (DBT), Government of India [BT/PR16325/NER/95/117/2015] and Science and Engineering Research Board (SERB), Department of Science and Technology, Government of India [Early Career Research Award; ECR/2015/000205].
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Deori, N.M., Kale, A., Maurya, P.K. et al. Peroxisomes: role in cellular ageing and age related disorders. Biogerontology 19, 303–324 (2018). https://doi.org/10.1007/s10522-018-9761-9
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DOI: https://doi.org/10.1007/s10522-018-9761-9