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An investigation into the relationship between anti-Helicobacter pylori and anti-Saccharomyces cerevisiae antibodies in patients with axial spondyloarthritis and Crohn disease

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Abstract

Spondyloarthritis (SpA) is a musculoskeletal inflammatory disease linked with immune responses to intestinal microbiota, and subclinical intestinal ulcerations that are closely related to inflammatory bowel diseases. Helicobacter pylori is a common cause of gastroduodenal ulceration, and anti-Saccharomyces cerevisiae antibodies (ASCA) are associated with intestinal inflammation in both Crohn disease (CD) and SpA. We investigated the relationship between H. pylori and ASCA. Ninety-one patients with axial SpA and forty with CD were included. ASCA IgG/IgA and anti-H. pylori IgG titers were assessed by ELISA. The proportion of ASCA+ patients in the positive and negative anti-H. pylori IgG groups with SpA and CD were compared using Chi-square tests, and correlations were evaluated using the Spearman’s coefficient. Anti-H. pylori IgG titers were significantly negatively correlated with the ASCA IgG (r = −0.563, p < 0.001) and IgA (r = −0.342, p = 0.019) titers in the axial SpA patients. The same pattern of negative correlation was also observed in the CD patients. Anti-H. pylori+ serology was significantly more frequent in axial SpA patients than in those with CD (52.4 vs. 18.4 %, p < 0.001), while ASCA+ serology was significantly more frequent in CD patients than in SpA patients. A negative correlation between the anti-H. pylori titers and ASCA was found for axial SpA and CD. Anti-H. pylori+ serology was more frequent in SpA than in CD, while ASCA positivity was more frequent in CD patients than in those with SpA. A possible influence of H. pylori on the development of ASCA needs further investigation.

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Acknowledgments

We are grateful to Dr. Paulo Fontoura Freitas for statistical help and to laboratory technician Maria Aparecida Rosa Cunha Cordeiro (Cida) for her kind cooperation during this study. This study was partially supported by the University Hospital, UFSC.

Conflict of interest

The authors have no conflict of interest.

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Authors and Affiliations

  1. Universidade Federal de Santa Catarina (UFSC), Florianópolis, Brazil

    Igor Kunze Rodrigues & Kenia Rodrigues de Andrade

  2. Clinical Analysis Laboratory, University Hospital, UFSC, Florianópolis, Brazil

    Michele Andrigueti, Ione Dilma de Oliveira Gil & Maria Luiza Bazzo

  3. Internal Medicine Department, UFSC, Florianópolis, Brazil

    Leonardo de Lucca Schiavon & Fabricio Souza Neves

  4. Rheumatology Unit, University Hospital, UFSC, Florianópolis, Brazil

    Ivanio Alves Pereira & Adriana Fontes Zimmermann

  5. Universidade do Sul de Santa Catarina (UNISUL), Palhoça, Brazil

    Ivanio Alves Pereira, Gláucio Ricardo Werner de Castro & Luciano Nascimento Saporiti

  6. Biochemistry and Pharmacy Department, UFSC, Florianópolis, Brazil

    Maria Luiza Bazzo

  7. Departamento de Clinica Médica, Hospital Universitário (UFSC), 3 Andar, Trindade, Florianópolis, SC, 88040-900, Brazil

    Fabricio Souza Neves

Authors
  1. Igor Kunze Rodrigues
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  2. Michele Andrigueti
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Correspondence to Fabricio Souza Neves.

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Rodrigues, I.K., Andrigueti, M., de Oliveira Gil, I.D. et al. An investigation into the relationship between anti-Helicobacter pylori and anti-Saccharomyces cerevisiae antibodies in patients with axial spondyloarthritis and Crohn disease. Rheumatol Int 35, 359–366 (2015). https://doi.org/10.1007/s00296-014-3088-x

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  • DOI: https://doi.org/10.1007/s00296-014-3088-x

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