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Whole-Body Fluorescence Imaging in the Near-Infrared Window

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Optical Imaging in Human Disease and Biological Research

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 3233))

Abstract

Fluorescence imaging is one of the most widely used in vivo imaging methods for both fundamental research and clinical practice. Due to the reduced photon scattering, absorption, and autofluorescence in tissues, the emerging near-infrared (NIR) imaging (650–1700 nm) can afford deep tissue imaging with high spatiotemporal resolution and in vivo report the anatomical structures as well as the physiological activities in a whole-body level. Here, we give a brief introduction to fluorescence imaging in the first NIR (NIR-I, 650–950 nm) and second NIR (NIR-II, 1000–1700 nm) windows, summarize the recently developed NIR fluorophores and their applications in whole-body vascular system imaging, precision cancer theranostics, and regenerative medicine. Finally, the clinical applications and future prospects of in vivo NIR fluorescence imaging are also discussed.

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Authors and Affiliations

  1. CAS Key Laboratory of Nano-Bio Interface, Suzhou Key Laboratory of Functional Molecular Imaging Technology, Division of Nanobiomedicine and i-Lab, CAS Center for Excellence in Brain Science, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou, China

    Guangcun Chen, Chunyan Li, Yejun Zhang & Qiangbin Wang

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  1. Guangcun Chen
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  2. Chunyan Li
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  3. Yejun Zhang
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  4. Qiangbin Wang
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Correspondence to Qiangbin Wang .

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Editors and Affiliations

  1. State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Med-X Research Institute and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China

    Xunbin Wei

  2. School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China

    Bobo Gu

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Chen, G., Li, C., Zhang, Y., Wang, Q. (2021). Whole-Body Fluorescence Imaging in the Near-Infrared Window. In: Wei, X., Gu, B. (eds) Optical Imaging in Human Disease and Biological Research. Advances in Experimental Medicine and Biology, vol 3233. Springer, Singapore. https://doi.org/10.1007/978-981-15-7627-0_5

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