Abstract
Alzheimer’s disease (AD) is the most common type of dementia and is characterized by progressive cognitive decline. Increasing evidence has demonstrated that the autophagic process plays an important role in AD. In this chapter, we will discuss the role of autophagy in the pathogenesis of AD and other types of dementia, including dementia with Lewy bodies (DLB), frontotemporal dementia (FTD), vascular dementia (VD) and prion diseases. In addition, we will discuss autophagy-targeted therapies as future treatments for AD.
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References
Jiang T, Yu J, Zhu X et al (2014) Temsirolimus promotes autophagic clearance of amyloid-β and provides protective effects in cellular and animal models of Alzheimer’s disease. Pharmacol Res 81(81):54–63
Kou X, Chen N (2017) Resveratrol as a natural autophagy regulator for prevention and treatment of alzheimer’s disease. Nutrients 9(9):E927
Kragh CL, Ubhi K, Wysscorey T et al (2012) Autophagy in dementias. Brain Pathol 22(1):99–109
Lee J, Yu WH, Kumar A et al (2010) Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by alzheimer-related PS1 mutations. Cell 141(7):1146–1158
Li L, Zhang X, Yang D et al (2009) Hypoxia increases abeta generation by altering beta- and gamma-cleavage of app. Neurobiol Aging 30:1091–1098
Li L, Le W (2010) Autophagy dysfunction in Alzheimer’s disease. Neurodegener Dis 7(4):265–71
Li Q, Liu Y, Sun M et al (2017) Autophagy and Alzheimer’s Disease. Cell Mol Neurobiol 37(3):377–388
Liberski PP, Gajdusek DC, Brown P (2002) How do neurons degenerate in prion diseases or transmissible spongiform encephalopathies (TSEs): neuronal autophagy revisited. Acta Neurobiol Exp (Wars) 62(3):141–7
Liberski PP, Gajos A, Bogucki A (2017) Robust autophagy in optic nerves of experimental Creutzfeldt-Jakob disease and Gerstmann-Sträussler-Scheinker disease. Folia Neuropathol 55(4):289–294
Majumder S, Richardson A, Strong R et al (2011) Inducing autophagy by rapamycin before, but not after, the formation of plaques and tangles ameliorates cognitive deficits. PLoS ONE 6(9):e25416
Nixon RA (2007) Autophagy, amyloidogenesis and Alzheimer disease. Cell Sci 120:4081–4091
Nixon RA (2013) The role of autophagy in neurodegenerative disease. Nat Med 19(8):983–97
Nixon RA, Yang D (2011) Autophagy failure in Alzheimer’s disease—locating the primary defect. Neurobiol Dis 43(1):38–45
Pickford F, Masliah E, Britschgi M et al (2008) The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice. J Clin Invest 118:2190–2199
Sahara N, Maeda S, Takashima A (2008) Tau oligomerization: A role for tau aggregation intermediates linked to neurodegeneration. Curr Alzheimer Res 5:591–598
Sarah FF, Bridget KM, Zhen YY (2010) Cell “self-eating” (autophagy) mechanism in alzheimer’s disease. Mt Sinai J Med 77:59–68
Uddin MS, Mamun AA, Labu ZK et al (2019) Autophagic dysfunction in Alzheimer’s disease: cellular and molecular mechanistic approaches to halt Alzheimer’s pathogenesis. J Cell Physiol 234(6):8094–8112
Wolfe DM, Lee J, Kumar A et al (2013) Autophagy failure in Alzheimer’s disease and the role of defective lysosomal acidification. Eur J Neurosci 37(12):1949–61
Zareshahabadi A, Masliah E, Johnson GV et al (2015) Autophagy in Alzheimer’s disease. Rev Neurosci 26(4):385–395
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Chen, S., Zhou, Q., Ni, Y., Le, W. (2020). Autophagy and Alzheimer’s Disease. In: Le, W. (eds) Autophagy: Biology and Diseases. Advances in Experimental Medicine and Biology, vol 1207. Springer, Singapore. https://doi.org/10.1007/978-981-15-4272-5_1
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DOI: https://doi.org/10.1007/978-981-15-4272-5_1
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