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Parkinson’s Disease: Deep Brain Stimulation

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Stereotactic and Functional Neurosurgery

Abstract

Deep brain stimulation (DBS) is the gold standard therapy for Parkinson’s disease when medications no longer provide adequate and consistent benefit with respect to motor symptoms. In conjunction with ever-accumulating evidence for the safety, clinical effectiveness, and cost-effectiveness of DBS, our understanding of the neurophysiology of surgical targets has evolved substantially over the last two decades. This chapter focuses significant attention on these details, as they provide the foundation for understanding both how to target DBS leads in the absence of neurophysiological guidance and how the use of neurophysiological signals may evolve in the future, intraoperatively and in chronically implanted devices.

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Authors and Affiliations

  1. Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

    Donald J. Crammond

  2. Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

    R. Mark Richardson

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  1. Donald J. Crammond
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Correspondence to R. Mark Richardson .

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  1. Department of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA

    Nader Pouratian

  2. Department of Neurosurgery, Baylor College of Medicine, Houston, TX, USA

    Sameer A. Sheth

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Crammond, D.J., Richardson, R.M. (2020). Parkinson’s Disease: Deep Brain Stimulation. In: Pouratian, N., Sheth, S. (eds) Stereotactic and Functional Neurosurgery. Springer, Cham. https://doi.org/10.1007/978-3-030-34906-6_18

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