This review article describes the current status and future perspectives of site-specific drug
delivery by means of macromolecular carrier systems. Basic aspects and recent advances of …

As part of the strategy for the design of macromolecular carriers for drug targeting, the disposition
characteristics of macromolecules were studied in mice bearing tumors that served as …

The development of exosomes as delivery vehicles requires understanding how and where
exogenously administered exosomes are distributed in vivo. In the present study, we …

Purpose. We examined the stability and disposition characteristics of a naked plasmid DNA
pCAT as a model gene after intravenous injection in mice to construct the strategy of in vivo …

Cationic liposomes and polymers have been accepted as effective non-viral vectors for gene
delivery with low immunogenicity unlike viral vectors. However, the lack of organ or cell …

Previous studies using B16BL6-derived exosomes labelled with gLuc–lactadherin (gLuc-LA),
a fusion protein of Gaussia luciferase (a reporter protein) and lactadherin (an exosome-…

Exosomes are cell-derived vesicles with a diameter 30–120 nm. Exosomes contain
endogenous proteins and nucleic acids; delivery of these molecules to exosome-recipient cells …

Macromolecules can extravasate across the normal endothelium by transcapillary pinocytosis
as well as by passage through interendothelial cell junctions, gaps or fenestrae. The main …

The cytotoxic effect of various macromolecules in cultured bovine brain microvessel endothelial
cells, mouse peritoneal macrophages, and rat hepatocytes was analyzed by measuring …

Mitomycin C–Dextran conjugates (MMC-D) were intravenously (iv) injected in mice bearing
subcutaneous sarcoma 180. The tissue distribution was determined for three 14 C-labeled …