G protein-coupled receptors (GPCRs) play a major role in signal transduction and are
targets of many therapeutic drugs. The regulator of G protein signaling (RGS) proteins form a …

The synthesis and structure−activity relationship of a novel series of compounds with combined
effects on 5-HT 3A and 5-HT 1A receptors and on the serotonin (5-HT) transporter (SERT…

1-[2-(2,4-Dimethylphenyl-sulfanyl)-phenyl]-piperazine (Lu AA21004) is a human (h) serotonin
(5-HT) 3A receptor antagonist (K i = 3.7 nM), h5-HT 7 receptor antagonist (K i = 19 nM), h5-…

Regulators of G protein signaling (RGS) are GTPase-accelerating proteins (GAPs), which
can inhibit heterotrimeric G protein pathways. In this study, we provide experimental and …

The neuropeptide galanin mediates its effects through the receptor subtypes Gal 1 , Gal 2 ,
and Gal 3 and has been implicated in anxiety- and depression-related behaviors. …

Several previous human postmortem experiments have detected an increase in striatal [ 3 H]WIN
35428 binding to the dopamine transporter (DAT) in chronic cocaine users. However, …

Rationale Escitalopram is a widely used antidepressant for the treatment of patients with
major depression. It is the pure S-enantiomer of racemic citalopram. Several clinical trials and …

RGS (regulators of Gprotein signaling) proteins are GTPase-activating proteins for the Gα
subunits of heterotrimeric G proteins and act to regulate signaling by rapidly cycling G protein. …

Melanopsin, expressed in a subset of retinal ganglion cells, mediates behavioral adaptation
to ambient light and other non-image-forming photic responses. This has raised the …

Regulator of G-protein signaling (RGS) proteins accelerate GTP hydrolysis by Gα subunits
speeding deactivation. Gα deactivation kinetics mediated by RGS are too fast to be directly …